The Universal Donor with High Titre Iso-agglutinins

“…The most extensive observations in this connection were reported by Aubert et al (2), who described instances of chills, fever and evidences of blood destruction, but no serious complications following such transfusions. Reports of severe reactions in response to the injection of incompatible group-O blood have, however, appeared from time to time.…”

mentioning

confidence: 89%

A Clinical Study of Transfusion Reactions: The Hemolytic Effect of Group-O Blood and Pooled Plasma Containing Incompatible Isoagglutinins

Ebert

Emerson²

1946

J. Clin. Invest.

View full text Add to dashboard Cite

The stored blood employed during World War II for the treatment of battle casualties was almost exclusively group-O blood, in consequence of which patients of blood groups A, B and AB were obliged to receive incompatible isoagglutinins in the course of transfusion. Anti-A and anti-B isoagglutinins, incompletely absorbed in the process of pooling, were likewise contained in the dried plasma supplied by the Army. Thus, all patients of blood groups other than group 0 receiving pooled plasma, and over 50 per cent of those who were transfused with whole blood were subjected to the injection of incompatible isoagglutinins.The preponderance of evidence in the literature indicates that the transfusion of group-O blood into recipients of other blood groups rarely produces serious reactions (1).

show abstract

“…This factor is ignored by some clinicians who regularly use, for instance, individuals of group 0 for transfusion to individuals of any group. Nevertheless, as demonstrated recently by Aubert, Boorma#h, Dodd, and Loutit (1942), the transfusion of serum containing potent incompatible agglutinins can result in the destruction of some of the recipient's erythrocytes. In infants who have developed a haemolytic anaemia as the result of the passage of Rh agglutinins through the placenta it is obviously undesirable to transfuse further amounts, and for this reason the transfusion of blood from the mother is to be deprecated.…”

Section: Reactions In Recently Delivered Womenmentioning

confidence: 99%