“…The mutation spectrum of our cohort was similar to that reported by a recent study which performed 425 panel sequencing of 114 lesions of MPLC. 42 We observed significantly higher mutational frequency of RBM10 and lower mutational frequencies of TP53, PIK3CA and STK11 in super MPLC than conventional LUAD, indicating the distinct molecular mechanisms underlying the pathogenesis of super MPLC. Previous studies showed that somatic mutations in specific oncogenes, including BRAF, NRAS and EGFR, were early genomic events for LUAD, 43 and the mutations of the oncogenes were also identified in the pre-invasive lesions of super MPLC, suggesting their important roles in the early pathogenesis.…”