The Unique Clinical Features and Outcome of Infectious Endocarditis and Vertebral Osteomyelitis Co-infection

Koslow, Matthew; Kuperstein, Rafael; Eshed, Iris; Perelman, Marina; Maor, Elad; Sidi, Yechezkel

doi:10.1016/j.amjmed.2014.02.023

Cited by 51 publications

(31 citation statements)

References 17 publications

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“…aureus [ 16 ]. Two other studies reported an association between PVO caused by Streptococcus spp or Enterococcus spp and the diagnosis of associated IE [ 17 , 18 ]. Similarly, a retrospective series of 92 IE patients identified 14 with PVO.…”

Section: Discussionmentioning

confidence: 99%

Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes

et al. 2017

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BackgroundThe incidence of pyogenic vertebral osteomyelitis (PVO) has increased over the past two decades. One possible cause of this increase is the aging of the population, which results in more comorbidities in high income countries.ObjectiveTo better characterize the clinical presentation and outcome of PVO in the elderly.DesignWe conducted a post-hoc analysis of a previously published trial that studied treatment duration in PVO and compared the presentation and outcomes according to age.ParticipantsOur analysis included 351 patients among whom 85 (24%) were 75-years-old or more.ResultsThere were no significant differences in the socio-demographics of the patients. Neoplasia and chronic inflammatory diseases were more common in the older group: 34% vs. 19% (p = 0.021) and 9% versus 1% (p = 0.004), respectively. There were no significant differences in clinical and radiological presentations between the groups in terms of back pain (337/351, 97%), fever (182/351, 52%), PVO localization, neurological signs and epidural abscess. Associated infective endocarditis (IE) was more frequent in the older group (37% vs. 14%, p<0.001). Streptococci were more frequently involved in infections of older patients (29% vs. 14%, p = 0.003) in contrast to Staphylococcus aureus (31% vs. 45%, p = 0.03). Older patients displayed higher mortality rates at 1 year (21% vs. 3%, p<0.001) and more adverse events related to cardiorespiratory failure (10.6% vs. 3.8%, p = 0.025), but had similar quality of life among the survivors.ConclusionDuring PVO, the clinical and radiological findings are similar in older patients. Global mortality rates are higher in older patients compared to younger patients, which could be explained by the increased frequency of neoplasia at diagnosis and higher prevalence of associated IE in the elderly.

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Section: Discussionmentioning

confidence: 99%

Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes

et al. 2017

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“…U ok. 10% pacjentów wy-stępują bóle stawów, a u 12-15% bóle mięśni [282,286]. Bóle pleców obserwuje się i ok. 13% chorych, a ból w okolicy lędź-wiowej jest najczęściej występującym objawem u osób z IZW oraz zapaleniem szpiku kręgów [282,283,287,288]. Bóle stawów obwodowych występują w ok. 14% przypadków [282].…”

Section: Objawy Mięśniowo-szkieletoweunclassified

“…IZW może komplikować lub być powikłane przez ropne zapalenie szpiku. Częstość występowania IZW w zapaleniu szpiku kręgów jest wyższa [288,289] w przypadku IZW spowodowanego przez Streptococcus viridans. U pacjentów z IZW, którzy skażą się na ból pleców lub bóle kostne, należy wykonać CT albo lepiej MRI kręgosłupa lub PET/CT całego ciała z zastosowaniem 18 F-FDG [290].…”

Section: Objawy Mięśniowo-szkieletoweunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

212

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“…Спондилодисцит является проявлением хронического дегенеративно-дистрофического процесса с образованием протрузии и грыж позвоночного столба, для которых характерен длительный болевой синдром. При ýтом нарушаются иннервация, кровоснабжение, ликвородинамика пораженной области, что вызывает асептико-воспалительный процесс в позвоночнике [3]. Снижение защитных сил организма и хронические очаги инфекции приводят к заносу патогенных микроорганизмов в участки поражения позвоночника.…”

Section: резюмеunclassified

Infectious endocarditis сomplicated spondilodiscitis

Талипова¹,

Жолдин²,

Сейтмагамбетова³

et al. 2018

Bûll. sib. med.

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This publication presents a clinical case of infectious endocarditis in an adult male aged 60, with manifestation of the disease in the form of spondilodiscitis. The presented observation demonstrates the development of onset of infectious endocarditis of bacterial spondylodiscitis in the adult patient. For a long time the patient’s intensive pain in the lumbar region could not be connected with infective endocarditis. According to the results of the examination the changes in the spine were not evaluated as an onset of IE. Dynamic observation and control MRT study allowed for the conclusion about bacterial spondilodiscitis in our patient with IE and to connect these two processes. In such clinical cases, MRT of the spine or positron emission tomography combined with computed tomography using a radiopharmaceutical 18F-fluorodeoxyglucose (F-FDG- PET / CT) of the whole body is recommended. In the case of a specific spondilodiscitis, the continuation of antibacterial therapy is determined by signs of inflammatory activity on F-FDG-PET / CT or MRT of the spine.

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The Unique Clinical Features and Outcome of Infectious Endocarditis and Vertebral Osteomyelitis Co-infection

Cited by 51 publications

References 17 publications

Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes

Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes

2015 ESC Guidelines for the management of infective endocarditis

Infectious endocarditis сomplicated spondilodiscitis

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