The Uniform Data Set, Czech Version: Normative Data in Older Adults from an International Perspective

Nikolai, Tomáš; Štěpánková, Hana; Kopeček, Miloslav; Šulc, Zdeněk; Vyhnálek, Martin; Bezdíček, Ondřej

doi:10.3233/jad-170595

Cited by 28 publications

(16 citation statements)

References 40 publications

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“…The neuropsychological battery included the Mini-Mental State Examination (MMSE) as a screening of global cognitive function and the following tests to assess five ( Albert et al, 2011 ) cognitive domains: (1) memory by the Rey Auditory Verbal Learning Test (RAVLT), Logical Memory from the Wechsler Memory Scale-Third Edition (LM), and Rey–Osterrieth Complex Figure Test (ROCFT recall after 3 min); (2) executive function by the Trail Making Test B (TMT B), phonemic verbal fluency—letters N, K, and P (P-VF) and Prague Stroop test—colors (PST); (3) language by the Boston Naming Test 30-item version (BNT) and category verbal fluency—animals (C-VF); (4) attention and working memory by the Trial Making Test A (TMT A) and Digit Span Forward and Backward (DS) from the Wechsler Adult Intelligence Scale-Third Edition; and (5) visuospatial function by the Rey–Osterrieth Complex Figure Test (ROCFT copy) ( Nikolai et al, 2018 ). All scores are presented in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort

Matušková

Ismail²,

Nikolai³

et al. 2021

Front. Aging Neurosci.

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ObjectivesMild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain changes. Our aim was to explore structural correlates of NPS in a non-demented memory clinic sample using the Mild Behavioral Impairment Checklist (MBI-C) that has been developed to measure MBI.MethodsOne hundred sixteen non-demented older adults from the Czech Brain Aging Study with subjective cognitive concerns were classified as subjective cognitive decline (n = 37) or mild cognitive impairment (n = 79). Participants underwent neurological and neuropsychological examinations and brain magnetic resonance imaging (MRI) (1.5 T). The Czech version of the MBI-C was administered to participants’ informants. Five a priori selected brain regions were measured, namely, thicknesses of the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and entorhinal cortex (ERC) and volume of the hippocampus (HV), and correlated with MBI-C total and domain scores.ResultsEntorhinal cortex was associated with MBI-C total score (rS = −0.368, p < 0.001) and with impulse dyscontrol score (rS = −0.284, p = 0.002). HV was associated with decreased motivation (rS = −0.248, p = 0.008) and impulse dyscontrol score (rS = −0.240, p = 0.011).ConclusionNeuropsychiatric symptoms, particularly in the MBI impulse dyscontrol and motivation domains, are associated with medial temporal lobe atrophy in a clinical cohort of non-demented older adults. This study supports earlier involvement of temporal rather than frontal regions in NPS manifestation. Since these regions are typically affected early in the course of Alzheimer’s disease (AD), the MBI-C may potentially help further identify individuals at-risk of developing AD dementia.

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Section: Methodsmentioning

confidence: 99%

Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort

Matušková

Ismail²,

Nikolai³

et al. 2021

Front. Aging Neurosci.

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“…Lower education refers to basic or lower secondary schools, such as trade schools, without the state leaving/graduation exam (i.e., without “maturita” in Czechia; 8–16 years of reported schooling in our sample); and higher education refers to secondary or high schools, including the state graduation exam, and tertiary schools or universities (11–33 years of reported schooling in our sample). This qualitative categorization of education is frequently used in normative studies of cognitive tests as the education system changed in the past century several times, and a number of years is not the best description of the level of acquired education (Bezdicek et al, 2015; Štěpánková et al, 2015; Kopecek et al, 2017; Nikolai et al, 2018). Advertising on the Internet, physicians’ and ophthalmologists’ offices, and snowball sampling were used.…”

Section: Methodsmentioning

confidence: 99%

“…It was administered using paper and pencil, except for two computerized tests. The battery consisted of tests frequently used in research and clinical practice related to aging and age-related cognitive disorders (Beeri et al, 2006; Weintraub et al, 2009; Swindell et al, 2012; Nikolai et al, 2018), assessing different domains such as episodic memory, attention, (verbal and visuo-graphomotor) psychomotor speed, and executive functions.…”

Section: Methodsmentioning

confidence: 99%

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Young-Old City-Dwellers Outperform Village Counterparts in Attention and Verbal Control Tasks

et al. 2019

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Cognitive performance is dynamic and shaped by individual biological and environmental factors throughout life. In psychology, besides the effects of age, education, and other often studied factors, the complexity of the lived-in environment and urbanicity in that context are yet to be elucidated. In this observational cross-sectional study, we compare cognitive performance in standard neuropsychological tests in healthy older persons from three different types of settlements in the Czechia: the capital city of Prague, towns, and villages. The groups were equal in terms of the age-band (60–74 years), the distribution of gender, education, past and current leisure activities, and cognitive health status (MMSE score). The results showed that Prague citizens had consistently better performance in all verbal tests (for memory and verbal control, i.e., executive function) and attention than persons from other areas. The groups did not differ in timed visuo-graphomotor performance. The conclusion is that the complex environment of a city may promote, in the long-term, certain cognitive abilities, distinguishable even in a developed, culturally homogenous country. The implications are: (a) the description of samples used in normative studies should include information on the lived-in environment for the reference of researchers and clinicians; and (b) individual clinical assessment should reflect the role of the patient’s environment where appropriate. The exact mechanisms and causes of the differences need further investigation.

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“…At each visit, all study participants undergo a standard set of procedures. Neurological and comprehensive neuropsychology examinations, including Uniform Data Set battery, are administered10 11; laboratory and vital function assessments are also performed. Sociodemographic, personal, pharmacological and family history data are collected.…”

Section: Methodsmentioning

confidence: 99%

Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic

et al. 2019

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PurposeIdentification of demographic, physical/physiological, lifestyle and genetic factors contributing to the onset of dementia, specifically Alzheimer disease (AD), and implementation of novel methods for early diagnosis are important to alleviate prevalence of dementia globally. The Czech Brain Aging Study (CBAS) is the first large, prospective study to address these issues in Central/Eastern Europe by enrolling non-demented adults aged 55+ years, collecting a variety of personal and biological measures and tracking cognitive function over time.ParticipantsThe CBAS recruitment was initiated in 2011 from memory clinics at Brno and Prague University Hospitals, and by the end of 2018, the study included 1228 participants. Annual follow-ups include collection of socioeconomic, lifestyle and personal history information, neurology, neuropsychology, laboratory, vital sign and brain MRI data. In a subset, biomarker assessment (cerebrospinal fluid (CSF) and amyloid positron emission tomography) and spatial navigation were performed. Participants were 69.7±8.1 years old and had 14.6±3.3 years of education at baseline, and 59% were women. By the end of 2018, 31% finished three and more years of follow-up; 9% converted to dementia. Apolipoprotein E status is available from 95% of the participants. The biological sample bank linked to CBAS database contained CSF, serum and DNA.Findings to dateOverall, the findings, mainly from cross-sectional analyses, indicate that spatial navigation is a promising marker of early AD and that it can be distinguished from other cognitive functions. Specificity of several standard memory tests for early AD pathology was assessed with implications for clinical practice. The relationship of various lifestyle factors to cognition and brain atrophy was reported.Future plansRecruitment is ongoing with secured funding. Longitudinal data analyses are currently being conducted. Proposals for collaboration on specific data from the database or biospecimen, as well as collaborations with similar cohort studies to increase sample size, are welcome. Study details are available online (www.cbas.cz).

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The Uniform Data Set, Czech Version: Normative Data in Older Adults from an International Perspective

Abstract: The present study determines the psychometric properties of the UDS-Cz and establishes normative values in the aging Czech population, which can be used in clinical settings.

Cited by 28 publications

References 40 publications

Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort

Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort

Young-Old City-Dwellers Outperform Village Counterparts in Attention and Verbal Control Tasks

Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic

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