The unholy trinity of human herpesvirus 8-associated malignancy in a person living with HIV-1

While infection should always lead the differential when a patient with AIDS presents with fever, inflammatory and malignant aetiologies should also be considered. With profound immunocompromise, malignancies can develop as sequelae of viral oncogene expression. Human herpesvirus 8 (HHV-8) infection drives several AIDS-related cancers including Kaposi sarcoma (KS), multicentric Castleman disease and primary effusion lymphoma (PEL), which can present simultaneously with variable clinical features. Herein, we describe a case of synchronous visceral KS and extracavitary PEL in a patient with AIDS. The patient was treated with systemic chemotherapy and remains in remission after four cycles. We review other cases of copresenting HHV-8-related malignancies, explore the salient pathomechanisms and clinical features of these cancers and discuss treatment strategies.

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Synchronous visceral Kaposi sarcoma and extracavitary primary effusion lymphoma in a patient with AIDS

Bradshaw

Oertling

Rezigh

2022

BMJ Case Rep

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The unholy trinity of human herpesvirus 8-associated malignancy in a person living with HIV-1

Cited by 1 publication

References 13 publications

Synchronous visceral Kaposi sarcoma and extracavitary primary effusion lymphoma in a patient with AIDS

Synchronous visceral Kaposi sarcoma and extracavitary primary effusion lymphoma in a patient with AIDS

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