The underexplored role of diverse stress factors in microbial biopolymer synthesis

Obruča, Stanislav; Sedláček, Petr; Koller, Martin

doi:10.1016/j.biortech.2021.124767

Cited by 55 publications

(25 citation statements)

References 135 publications

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“…Under different growth conditions, thermophilic microorganisms are exposed to oxidative stress due to the accumulation of ROSs causing direct or indirect damage to different macromolecules, including metalloproteins and affecting their ability to maintain redox homeostasis ( Farías et al, 2021 ) . Moreover, thermophilic bacterial cells could expose to various environmental stressors during the processes of dye degradation, including fluctuations in pH value, elevated pressure, and partial pressure of oxygen, and this could influence the oxidative stress responses ( Obruca et al, 2021 ). For example, in Pseudomonas putida, high oxygen partial pressure influences the oxidative stress response where genes for various peroxidases and glutathione-related proteins are up-regulated ( Farías et al, 2021 ) .…”

Section: Oxidative Stress In Thermophilesmentioning

confidence: 99%

Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater

2022

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Release of dye-containing textile wastewater into the environment causes severe pollution with serious consequences on aquatic life. Bioremediation of dyes using thermophilic microorganisms has recently attracted attention over conventional treatment techniques. Thermophiles have the natural ability to survive under extreme environmental conditions, including high dye concentration, because they possess stress response adaptation and regulation mechanisms. Therefore, dye detoxification by thermophiles could offer enormous opportunities for bioremediation at elevated temperatures. In addition, the processes of degradation generate reactive oxygen species (ROS) and subject cells to oxidative stress. However, thermophiles exhibit better adaptation to resist the effects of oxidative stress. Some of the major adaptation mechanisms of thermophiles include macromolecule repair system; enzymes such as superoxide dismutase, catalase, and glutathione peroxidase; and non-enzymatic antioxidants like extracellular polymeric substance (EPSs), polyhydroxyalkanoates (PHAs), etc. In addition, different bacteria also possess enzymes that are directly involved in dye degradation such as azoreductase, laccase, and peroxidase. Therefore, through these processes, dyes are first degraded into smaller intermediate products finally releasing products that are non-toxic or of low toxicity. In this review, we discuss the sources of oxidative stress in thermophiles, the adaptive response of thermophiles to redox stress and their roles in dye removal, and the regulation and crosstalk between responses to oxidative stress.

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Section: Oxidative Stress In Thermophilesmentioning

confidence: 99%

Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater

2022

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“…Observing such cells under the microscope, PHA inclusions appear as light refracting granules of spherical to ellipsoidal shape. Chemically, PHA are polyoxoesters of hydroxyalkanoic acids (54,55).…”

Section: Products Of White (Industrial) Biotechnologymentioning

confidence: 99%

Polyhydroxyalkanoate (PHA) Biopolyesters - Emerging and Major Products of Industrial Biotechnology

Mukherjee¹,

Koller

2022

The EuroBiotech Journal

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Background: Industrial Biotechnology (“White Biotechnology”) is the large-scale production of materials and chemicals using renewable raw materials along with biocatalysts like enzymes derived from microorganisms or by using microorganisms themselves (“whole cell biocatalysis”). While the production of ethanol has existed for several millennia and can be considered a product of Industrial Biotechnology, the application of complex and engineered biocatalysts to produce industrial scale products with acceptable economics is only a few decades old. Bioethanol as fuel, lactic acid as food and PolyHydroxyAlkanoates (PHA) as a processible material are some examples of products derived from Industrial Biotechnology. Purpose and Scope: Industrial Biotechnology is the sector of biotechnology that holds the most promise in reducing our dependence on fossil fuels and mitigating environmental degradation caused by pollution, since all products that are made today from fossil carbon feedstocks could be manufactured using Industrial Biotechnology – renewable carbon feedstocks and biocatalysts. To match the economics of fossil-based bulk products, Industrial Biotechnology-based processes must be sufficiently robust. This aspect continues to evolve with increased technological capabilities to engineer biocatalysts (including microorganisms) and the decreasing relative price difference between renewable and fossil carbon feedstocks. While there have been major successes in manufacturing products from Industrial Biotechnology, challenges exist, although its promise is real. Here, PHA biopolymers are a class of product that is fulfilling this promise. Summary and Conclusion: The authors illustrate the benefits and challenges of Industrial Biotechnology, the circularity and sustainability of such processes, its role in reducing supply chain issues, and alleviating societal problems like poverty and hunger. With increasing awareness among the general public and policy makers of the dangers posed by climate change, pollution and persistent societal issues, Industrial Biotechnology holds the promise of solving these major problems and is poised for a transformative upswing in the manufacture of bulk chemicals and materials from renewable feedstocks and biocatalysts.

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“…Physiologically, PHB is produced as an energy storage and carbon storage material in the cytoplasm of microorganisms under unbalanced nutrient conditions ( Tan et al, 2014 ). Moreover, PHB plays an essential role in enhancing the stress robustness of PHB-accumulating microbial cells ( Obruca et al, 2021 ). Reportedly, there are more than 300 microorganisms that can be used as PHB producers ( Grigore et al, 2019 ), including Azotobacter, Bacillus, Alcaligenes, Pseudomonas, Rhizobium, and Rhodospirillum ( Ertan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Review on Enhancing Cupriavidus necator Fermentation for Poly(3-hydroxybutyrate) (PHB) Production From Low-Cost Carbon Sources

Zhang

Jiang

Tsui

et al. 2022

Front. Bioeng. Biotechnol.

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In the context of a circular economy, bioplastic production using biodegradable materials such as poly(3-hydroxybutyrate) (PHB) has been proposed as a promising solution to fundamentally solve the disposal issue of plastic waste. PHB production techniques through fermentation of PHB-accumulating microbes such as Cupriavidus necator have been revolutionized over the past several years with the development of new strategies such as metabolic engineering. This review comprehensively summarizes the latest PHB production technologies via Cupriavidus necator fermentation. The mechanism of the biosynthesis pathway for PHB production was first assessed. PHB production efficiencies of common carbon sources, including food waste, lignocellulosic materials, glycerol, and carbon dioxide, were then summarized and critically analyzed. The key findings in enhancing strategies for PHB production in recent years, including pre-treatment methods, nutrient limitations, feeding optimization strategies, and metabolism engineering strategies, were summarized. Furthermore, technical challenges and future prospects of strategies for enhanced production efficiencies of PHB were also highlighted. Based on the overview of the current enhancing technologies, more pilot-scale and larger-scale tests are essential for future implementation of enhancing strategies in full-scale biogas plants. Critical analyses of various enhancing strategies would facilitate the establishment of more sustainable microbial fermentation systems for better waste management and greater efficiency of PHB production.

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The underexplored role of diverse stress factors in microbial biopolymer synthesis

Cited by 55 publications

References 135 publications

Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater

Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater

Polyhydroxyalkanoate (PHA) Biopolyesters - Emerging and Major Products of Industrial Biotechnology

A Review on Enhancing Cupriavidus necator Fermentation for Poly(3-hydroxybutyrate) (PHB) Production From Low-Cost Carbon Sources

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