The ultraviolet photochemistry of thymidylyl-(3′→5′)-thymidine

Johns, H. E.; Pearson, Mark; Leblanc, J.; Helleiner, C. W.

doi:10.1016/s0022-2836(64)80223-0

Cited by 195 publications

(140 citation statements)

References 22 publications

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“…The transient spectra recorded for TMP solutions at 200 ns correspond to the well characterized TMP triplet, [8][9][10] In spite of the absence of any absorption band in the spectra recorded for (dT) 20 at the nanosecond and at the microsecond time-scales, a band peaking at 325 nm, typical of the (6-4) adduct, 4,12 does appear at the millisecond time-scale (Figure 2b). The transient signals recorded from 310 nm to 360 nm have the same time-behavior.…”

Section: Figurementioning

confidence: 99%

Time-Resolved Study of Thymine Dimer Formation

2005

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The formation of thymine dimers in the single-stranded oligonucleotide, (dT)20, is studied at room temperature by laser flash photolysis using 266 nm excitation. It is shown that the (6-4) adduct is formed within 4 ms via a reactive intermediate. The formation of cyclobutane dimers is faster than 200 ns. The overall quantum yield for the (6-4) formation is (3.7 ± 0.3) × 10-3, and that of the cyclobutane dimers is (2.8 ± 0.2) × 10-2. No triplet absorption is detected, showing that either the intersystem crossing yield decreases by 1 order of magnitude upon oligomerization (<1.4 × 10-3) or the triplet state reacts with unit efficiency in less than 200 ns to yield cyclobutane dimers.

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Section: Figurementioning

confidence: 99%

Time-Resolved Study of Thymine Dimer Formation

2005

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“…Johns et al [42] found that UV irradiation of thymidylyl(3 0 -5 0 )thymidine, d(TpT), resulted in the formation of a product (TpT 4 ) that differed from the CPD. This product had an absorption maximum at 325 nm, and was converted to a second product (TpT 3 ) by irradiation at 313 nm.…”

Section: The (6-4) Photoproducts and Their Dewar Valence Isomersmentioning

confidence: 99%

“…The chemical structure of TpT 3 , produced by irradiation of the (6-4) photoproduct at 313 nm [42], was determined by Taylor and Cohrs [55]. These authors found that the 2-pyrimidone ring in the (6-4) photoproduct was photoisomerized to a Dewar-type structure (7), and therefore, this lesion has been termed the Dewar valence isomer or the Dewar photoproduct.…”

Section: The (6-4) Photoproducts and Their Dewar Valence Isomersmentioning

confidence: 99%

Pyrimidine Dimers: UV‐Induced DNA Damage

Iwai

2008

Modified Nucleosides

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“…As intermediates, the oxetane structures are produced [12][13][14][15]. The oxetane adduct has been shown in model systems to be converted into Dewar valence isomers upon exposure to UVB light [16].…”

Section: Introductionmentioning

confidence: 99%

“…However, only few of them explore the mechanisms of the cyclodimerization of pyrimidine bases. For example, the cyclodimerizations of pyrimidine nucleobases to cys-syn cyclobutane dimers have been studied at the CASPT2 (12,12) level of theory [30,36,37]. In these investigations special attention is paid to the radiationless deactivation of the driven excited state to the ground state, but not to the conical intersections S 0 -S 1 .…”

Section: Introductionmentioning

confidence: 99%