The ultrastructure of lymphocytes in schizophrenia

Na, Uranova; Bonartsev, P D; Os, Brusov; Ma, Morozova; Rachmanova, V.I.; Orlovskaya, D.D.

doi:10.1080/15622970600960207

Cited by 36 publications

(26 citation statements)

References 34 publications

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“…Mononuclear cells of SZ patients had enlarged mitochondria with fragmented cristae, which was independent of antipsychotic drug type used (Inuwa et al, 2005). In a similar study, activated lymphocytes in individuals with SZ had a lower mitochondrial density than controls (Uranova et al, 2007).…”

Section: Morphological and Physiological Changes In Mitochondria In Pmentioning

confidence: 84%

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Clay

Sillivan

Konradi

2010

Intl J of Devlp Neuroscience

354

263

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Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders. Several pieces of evidence point to an underlying dysfunction of mitochondria: i) decreased mitochondrial respiration; (ii) changes in mitochondrial morphology; iii) increases in mitochondrial DNA (mtDNA) polymorphisms and in levels of mtDNA mutations; iv) downregulation of nuclear mRNA molecules and proteins involved in mitochondrial respiration; v) decreased high-energy phosphates and decreased pH in the brain; and vi) psychotic and affective symptoms, and cognitive decline in mitochondrial disorders. Furthermore, transgenic mice with mutated mitochondrial DNA polymerase show mood disorder-like phenotypes. In this review, we will discuss the genetic and physiological components of mitochondria and the evidence for mitochondrial abnormalities in BPD and SZ. We will furthermore describe the role of mitochondria during brain development and the effect of current drugs for mental illness on mitochondrial function. Understanding the role of mitochondria, both developmentally as well as in the ailing brain, is of critical importance to elucidate pathophysiological mechanisms in psychiatric disorders.

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Section: Morphological and Physiological Changes In Mitochondria In Pmentioning

confidence: 84%

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Clay

Sillivan

Konradi

2010

Intl J of Devlp Neuroscience

354

263

View full text Add to dashboard Cite

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“…15 The heteromeric signaling complex, resulting from binding of TGF-β1 to type II receptor and in turn type I receptor, transduces signals through receptor-regulated Smads (Smad2/3) and common-partner Smad (Smad4), leading to transcriptional regulation of target genes. A number of non-canonical TGF-β signaling pathways have also been identified, including the rho-like guanosine triphosphatases, 16,17 PI3K/Akt, 18–21 and the mitogen-activated protein kinases (MAPKs), namely extracellular signal-regulated kinase 1/2, 22,23 c-Jun N-terminal kinase (JNK), 24–26 and p38 MAPK.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis

Ding

Choi

2014

Seminars in Nephrology

121

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Autophagy is a highly conserved homoeostatic mechanism for cell survival under conditions of stress, and is widely implicated as an important pathway in many biological processes and diseases. In progressive kidney diseases, fibrosis represents the common pathway to end-stage kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been established as a central mediator of kidney fibrosis. Recently emerging body of evidence from studies in renal cells in culture and experimental animal models suggests that TGF-β1 regulates autophagy and that autophagy regulates many critical aspects of normal and disease conditions associated with kidney fibrosis, such as tubulointerstitial fibrosis, glomerulosclerosis, and diabetic nephropathy. Here, we review the recent advances exploring the process of autophagy, its regulation by TGF-β1, and implication in the pathogenesis of progressive kidney fibrosis and injury responses. Understanding the cellular and molecular bases of this process is crucial for identifying potential new diagnostic and therapeutic targets of kidney fibrosis.

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“…One study found differences in the genotypic distribution of a functional polymorphism of manganese superoxide dismutase, thought to protect mitochondria from reactive oxygen species, among several DSM‐IV subgroups of SZ, including SZP (Akyol et al,2005). In another study, lymphocytes analyzed from paranoid schizophrenia patients and controls showed less mitochondrial volume in the patients in certain types of lymphocytes (Uranova et al,2007). Moreover, the severity of the mitochondrial deficit was positively correlated with symptom severity, linking paranoid symptoms with mitochondrial impairment, albeit in blood (Uranova et al,2007).…”

Section: Discussionmentioning

confidence: 95%

“…In another study, lymphocytes analyzed from paranoid schizophrenia patients and controls showed less mitochondrial volume in the patients in certain types of lymphocytes (Uranova et al,2007). Moreover, the severity of the mitochondrial deficit was positively correlated with symptom severity, linking paranoid symptoms with mitochondrial impairment, albeit in blood (Uranova et al,2007). A decrease in mitochondrial number could therefore be associated with the symptoms of paranoia.…”

Section: Discussionmentioning

confidence: 95%

Development of fault point locating system for underground transmission lines using optical fiber current sensors

Kurosawa

Kondo

Nasukawa

et al. 2011

Electrical Engineering Japan

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Fault point locating systems based on surge current detection have recently been used for fast recovery of underground transmission lines from faults. Electromagnetic induction type sensors have mainly been used for the detection of surge current. However, they are susceptible to electromagnetic noise which causes unstable system operation. To solve this problem, Tokyo Electric Power Co., Toko Electric Corporation, and Fujikura Ltd. jointly developed a new system using optical fiber current sensors. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 178(1): 21–28, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.20981

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The ultrastructure of lymphocytes in schizophrenia

Abstract: The data suggest that the excess of LB in schizophrenic patients is associated with the dysfunction of energy metabolism in LAL, and these abnormalities are related to schizophrenia.

Cited by 36 publications

References 34 publications

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis

Development of fault point locating system for underground transmission lines using optical fiber current sensors

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