The Ultrastructure of Human Tumours

Eyden, Brian; Banerjee, Shiladitya; Ru, Yongxin; Liberski, Paweł P.

doi:10.1007/978-3-642-39168-2

Cited by 4 publications

(1 citation statement)

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“…However, it should be highlighted that even under physiological conditions, at rest, connective tissues seem to be under some sort of mechanical tension 39,40. It could be speculated that myofibroblasts are involved in the cellular basis of such tensional homeostasis thanks to the presence of a contractile apparatus that contains bundles of actin microfilaments 41–43. It is assumed that, because of the myofibroblast content, fasciae not only passively transduce mechanical forces, but are also able to contract in an active way 44,45.…”

Section: Discussionmentioning

confidence: 99%

Electron microscopy of human fascia lata: focus on telocytes

Dawidowicz¹,

Szotek

Matysiak

et al. 2015

J Cellular Molecular Medi

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From the histological point of view, fascia lata is a dense connective tissue. Although extracellular matrix is certainly the most predominant fascia’s feature, there are also several cell populations encountered within this structure. The aim of this study was to describe the existence and characteristics of fascia lata cell populations viewed through a transmission electron microscope. Special emphasis was placed on telocytes as a particular interstitial cell type, recently discovered in a wide variety of tissues and organs such as the heart, skeletal muscles, skin, gastrointestinal tract, uterus and urinary system. The conducted study confirmed the existence of a telocyte population in fascia lata samples. Those cells fulfil main morphological criteria of telocytes, namely, the presence of very long, thin cell processes (telopodes) extending from a relatively small cell body. Aside from telocytes, we have found fibroblasts, mast cells and cells with features of myofibroblastic differentiation. This is the first time it has been shown that telocytes exist in human fascia. Currently, the exact role of those cells within the fascia is unknown and definitely deserves further attention. One can speculate that fascia lata telocytes likewise telocytes in other organs may be involved in regeneration, homeostasis and intracellular signalling.

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Section: Discussionmentioning

confidence: 99%

Electron microscopy of human fascia lata: focus on telocytes

Dawidowicz¹,

Szotek

Matysiak

et al. 2015

J Cellular Molecular Medi

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Processing and characterization of canine mixed mammary tumor using transmission electron microscopy

Audrey

Debut

Vaca

et al. 2017

Microscopy Res & Technique

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Canine mammary gland tumors represent the second most frequent type of neoplasm in dogs, being an important problem within veterinary medical field. Canine mixed mammary tumors are the most common; the use of a transmission electron microscope (TEM) can contribute as a tool in its diagnosis by determining the characteristics of cellular components from numerous neoplasms. The aim of this study was to characterize cytologically canine mammary mixed tumor by the use of the TEM. A biopsy collected from an 11 years old bitch Shih-Tzu and analyzed by histopathology was used for ultrastructural analysis. Specimens obtained were double stained using uranyl acetate and lead citrate prior to observation in the TEM. The protocol established to transmission electron microscopy observation allowed the identification of main cellular characteristics of canine mixed mammary tumors; however, it was not possible a detailed visualization of the organelles due to the preservation of the biopsy in formaldehyde.

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Morphological features of fascia lata in relation to fascia diseases

Szotek

Dawidowicz²,

Eyden

et al. 2016

Ultrastructural Pathology

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Fascia lata is an important element of the fascial system, which forms the continuum of connective tissue throughout the body. This deep fascia envelops the entire thigh and hip area and its main function is to transmit mechanical forces generated by the musculoskeletal system of the lower extremities. Fascia lata is also known as a useful and easily harvested graft material. Despite its crucial role in lower extremity biomechanics and wide-ranging applications in plastic and reconstructive surgery, both the structure of fascia lata and particularly the cells populating this tissue are relatively unexplored and therefore poorly understood. The aim of this study was to characterize the main cell populations encountered within human fascia lata and to try to understand their role in health and diseases. Pathologically unchanged human fascia lata was obtained post mortem from adult males. The specimens were analyzed under light, electron, and confocal microscopy. On the basis of different visualization techniques, we were able to characterize in detail the cells populating human fascia lata. The main cells found were fibroblasts, fibrocytes, mast cells, cells showing myoid differentiation, nerve cells, and most interestingly, telocytes. Our results supplement the formerly inadequate information in the literature regarding the cellular components of deep fascial structure, may contribute to a better understanding of the pathogenesis of fascial disorders and improve fascia lata application as a graft material.

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The Ultrastructure of Human Tumours

Cited by 4 publications

References 0 publications

Electron microscopy of human fascia lata: focus on telocytes

Electron microscopy of human fascia lata: focus on telocytes

Processing and characterization of canine mixed mammary tumor using transmission electron microscopy

Morphological features of fascia lata in relation to fascia diseases

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