The ultra low dose combination medication ULDCM-310 triggers electro-encephalographic patterns in the rat brain in a dose and time dependent manner

Dimpfel, Wilfried; Roeska, Kerstin; Seilheimer, Bernd

doi:10.1016/j.eujim.2010.09.116

Cited by 3 publications

(3 citation statements)

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“…Whether or not such findings would be replicable with subjects identified using individualized homeopathic case taking interviews rather than the CTQ is a valid, but as yet unanswered, question. These data in human subjects extend findings from controlled animal studies that previously demonstrated the short-term ability of single or combination homeopathic remedies to alter waking EEG alpha and delta 29 and sleeping EEG delta wave activity. 930 Although it would be preferable to have comparable proportions of men and women in subsequent studies with larger samples, the current analyses were controlled for gender differences between groups.…”

Section: Discussionsupporting

confidence: 81%

Short-term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults

Bell¹,

Brooks²,

Howerter³

et al. 2011

Homeopathy

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Introduction Homeopathic pathogenetic trials usually rely on symptom self report measures. Adding objective biomarkers could enhance detection of subtle initial remedy effects. The present feasibility study examined electroencephalographic (EEG) effects of repeated olfactory administration of two polycrest remedies. Methods College student volunteers (ages 18–30, both sexes) from an introductory psychology course were screened for good health and relatively elevated Sulphur OR Pulsatilla symptom scores on the Homeopathic Constitutional Type Questionnaire. Subjects underwent a series of 3 once-weekly double-blind sessions during which they repeatedly sniffed the remedy matched to their CTQ type and solvent controls. Each remedy was given in a 6c, 12c, and 30c potency, one potency per week, in randomly assigned order. Solvent controls included both plain distilled water and a water-ethanol (95%) solution. All sniff test solutions were further diluted just prior to laboratory sessions (0.5 ml test solution in 150 ml distilled water). Within a session, remedies and control solvents were administered via 2-second sniffs (8 sniffs of each of 4 different succussion levels for the potency in randomized order). Primary outcome variable was relative EEG power (alpha 1 8–10 hertz; alpha 2 10–12 hertz) averaged over 19 electrode sites, including all succussions for a given potency. Results Mixed-effect models revealed significant main effects for remedy type (Sulphur>Pulsatilla) in both alpha bands, controlling for gender, baseline resting EEG alpha, and solvent control responses. Additional analyses showed significant non-linear interactions between dilution and time (weekly session) in alpha 2 for both remedies and alpha 1 for Sulphur. Conclusion EEG alpha offers an objective biomarker of remedy effects for future studies and potential method for distinguishing time-dependent effects of specific remedies and remedy potencies from one another.

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Section: Discussionsupporting

confidence: 81%

Short-term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults

Bell¹,

Brooks²,

Howerter³

et al. 2011

Homeopathy

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“…Subsequently, a number of HPTs using blinded methods to assess symptoms reported by volunteers have claimed positive results . There are also a number of reports that highly dilute medicines are associated with changes in EEG in animals …”

Section: Commentarymentioning

confidence: 99%

Electroencephalographic effects as an outcome measure in homeopathic pathogenetic trials

Fisher

2014

Focus on Alt & Comp Therapy

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“…41,42 Neurophysiological assessments enable utilization of more objective and sensitive tools than crude behavioral observations or self-report scales for assessing the real-time dynamics of an organism at integrative levels of functioning such as the central nervous system. 19,43 In animal research, for example, Ruiz-Vega et al 44 showed that homeopathically prepared medicines such as Coffea cruda at 30c potencies can produce increases in the electroencephalographic delta band power of slow wave sleep (stages 3 and 4) versus placebo.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia

Bell¹,

Howerter²,

Jackson³

et al. 2012

Homeopathy

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Background Investigators of homeopathy have proposed that nonlinear dynamical systems (NDS) and complex systems science offer conceptual and analytic tools for evaluating homeopathic remedy effects. Previous animal studies demonstrate that homeopathic medicines alter delta electroencephalographic (EEG) slow wave sleep. The present study extended findings of remedy-related sleep stage alterations in human subjects by testing the feasibility of using two different NDS analytic approaches to assess remedy effects on human slow wave sleep EEG. Methods Subjects (N=54) were young adult male and female college students with a history of coffee-related insomnia who participated in a larger 4-week study of the polysomnographic effects of homeopathic medicines on home-based all-night sleep recordings. Subjects took one bedtime dose of a homeopathic remedy (Coffea cruda or Nux vomica 30c). We computed multiscale entropy (MSE) and the correlation dimension (Mekler-D2) for stage 3 and 4 slow wave sleep EEG sampled in artifact-free 2-minute segments during the first two rapid-eye-movement (REM) cycles for remedy and post-remedy nights, controlling for placebo and post-placebo night effects. Results MSE results indicate significant, remedy-specific directional effects, especially later in the night (REM cycle 2) (CC: remedy night increases and post-remedy night decreases in MSE at multiple sites for both stages 3 and 4 in both REM cycles; NV: remedy night decreases and post-remedy night increases, mainly in stage 3 REM cycle 2 MSE). D2 analyses yielded more sporadic and inconsistent findings. Conclusions Homeopathic medicines Coffea cruda and Nux vomica in 30c potencies alter short-term nonlinear dynamic parameters of slow wave sleep EEG in healthy young adults. MSE may provide a more sensitive NDS analytic method than D2 for evaluating homeopathic remedy effects on human sleep EEG patterns.

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The ultra low dose combination medication ULDCM-310 triggers electro-encephalographic patterns in the rat brain in a dose and time dependent manner

Cited by 3 publications

References 0 publications

Short-term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults

Short-term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults

Electroencephalographic effects as an outcome measure in homeopathic pathogenetic trials

Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia

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