“…SMURF2 was shown to ubiquitinate and regulate stability, localisation, and functions of several critical proteins pertinent to cancer initiation, progression, and therapeutic response. These include TGF-β receptor and SMAD transducers 6–9 , the components of the Wnt/β-catenin signalling pathway Axin 10 and GSK3β 11 , DNA topology regulator Topo IIα 12 , epigenetic modifiers RNF20 13 , 14 , EZH2 14–16 , SIRT1 17 , transcription factors KLF5 18 , YY1 19 , SATB1 20 , ChREBP 21 , nuclear lamins 22 , 23 , as well as HECT- and RING-type E3s 24–26 . This broad target repertoire of SMURF2 suggests that modulation of its protein abundance and activity could have a profound impact on several essential molecular and cellular processes involved in the disease onset, progression, and therapeutic response.…”