The Ubiquitin Proteasome System and Nutrient Stress Response

Mackinnon, Erin; Stone, Sophia L.

doi:10.3389/fpls.2022.867419

Cited by 8 publications

(2 citation statements)

References 118 publications

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“…When exposed to external stimuli, ubiquitination is inhibited or promoted, which results in a higher degradation or stabilization of transporters, enzymes, ion channels, transcription regulators (like co-activators, transcription factors, and repressors), and signaling proteins (receptors and kinases). These alterations in protein abundance can enhance or prevent cellular responses 65 . According to the MCC algorithm, δ-COP was the hub gene in this module.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches

Zinati

Nazari

2023

Sci Rep

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Abiotic stress in cucumber (Cucumis sativus L.) may trigger distinct transcriptome responses, resulting in significant yield loss. More insight into the molecular underpinnings of the stress response can be gained by combining RNA-Seq meta-analysis with systems biology and machine learning. This can help pinpoint possible targets for engineering abiotic tolerance by revealing functional modules and key genes essential for the stress response. Therefore, to investigate the regulatory mechanism and key genes, a combination of these approaches was utilized in cucumber subjected to various abiotic stresses. Three significant abiotic stress-related modules were identified by gene co-expression network analysis (WGCNA). Three hub genes (RPL18, δ-COP, and EXLA2), ten transcription factors (TFs), one transcription regulator, and 12 protein kinases (PKs) were introduced as key genes. The results suggest that the identified PKs probably govern the coordination of cellular responses to abiotic stress in cucumber. Moreover, the C2H2 TF family may play a significant role in cucumber response to abiotic stress. Several C2H2 TF target stress-related genes were identified through co-expression and promoter analyses. Evaluation of the key identified genes using Random Forest, with an area under the curve of ROC (AUC) of 0.974 and an accuracy rate of 88.5%, demonstrates their prominent contributions in the cucumber response to abiotic stresses. These findings provide novel insights into the regulatory mechanism underlying abiotic stress response in cucumber and pave the way for cucumber genetic engineering toward improving tolerance ability under abiotic stress.

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Section: Discussionmentioning

confidence: 99%

Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches

Zinati

Nazari

2023

Sci Rep

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“…Additionally, ROS accumulation is a crucial factor linking autophagy and salt stress responses [ 11 ]. The UPS and SUMO systems have been extensively reviewed in several recent reviews [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]; thus they will be introduced only briefly. Further, in this review we discuss the recent research deciphering the role of autophagy in salt stress tolerance, with a particular focus on ATG8 as the key player in selective autophagy.…”

Section: Ubiquitin-mediated Protein Degradation In Plant Adaptation T...mentioning

confidence: 99%

The Role of Plant Ubiquitin-like Modifiers in the Formation of Salt Stress Tolerance

Dabravolski,

Isayenkov

2024

Plants

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The climate-driven challenges facing Earth necessitate a comprehensive understanding of the mechanisms facilitating plant resilience to environmental stressors. This review delves into the crucial role of ubiquitin-like modifiers, particularly focusing on ATG8-mediated autophagy, in bolstering plant tolerance to salt stress. Synthesising recent research, we unveil the multifaceted contributions of ATG8 to plant adaptation mechanisms amidst salt stress conditions, including stomatal regulation, photosynthetic efficiency, osmotic adjustment, and antioxidant defence. Furthermore, we elucidate the interconnectedness of autophagy with key phytohormone signalling pathways, advocating for further exploration into their molecular mechanisms. Our findings underscore the significance of understanding molecular mechanisms underlying ubiquitin-based protein degradation systems and autophagy in salt stress tolerance, offering valuable insights for designing innovative strategies to improve crop productivity and ensure global food security amidst increasing soil salinisation. By harnessing the potential of autophagy and other molecular mechanisms, we can foster sustainable agricultural practices and develop stress-tolerant crops resilient to salt stress.

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Ubiquitin-Like Protein FAT10 Promote Colorectal Cancer Progression by Affecting the Ubiquitination of Capn4

Cheng

Yuan

et al. 2023

Dig Dis Sci

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The Ubiquitin Proteasome System and Nutrient Stress Response

Cited by 8 publications

References 118 publications

Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches

Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches

The Role of Plant Ubiquitin-like Modifiers in the Formation of Salt Stress Tolerance

Ubiquitin-Like Protein FAT10 Promote Colorectal Cancer Progression by Affecting the Ubiquitination of Capn4

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