The ubiquitin‐proteasome pathway and enhanced activity of NF‐κB in gastric carcinoma

Wu, Ling‐Fei; Pu, Ze‐Jin; Jia, Feng; Li, Guoping; Zheng, Zhichao; Wenlv, Shen

doi:10.1002/jso.20952

Cited by 24 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Previous studies indicate that ubiquitin expression and 26S proteasome activation are increased in gastric cancer. 26 Moreover, proteasome inhibitors exert potent antiproliferative effects on gastric cancer cells. 18 As a pro-survival mechanism, macroautophagy have been reported to protect tumor cells from the cytotoxic effects of cancer therapy.…”

Section: Macroautophagy and Erk Phosphorylation Counteract The Antiprmentioning

confidence: 99%

Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells

Cho²,

Lee³

et al. 2010

Autophagy

View full text Add to dashboard Cite

show abstract

Section: Macroautophagy and Erk Phosphorylation Counteract The Antiprmentioning

confidence: 99%

Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells

Cho²,

Lee³

et al. 2010

Autophagy

View full text Add to dashboard Cite

show abstract

“…Ni et al [15] reported that high activity ubiquitin-proteasome pathway in both patient samples and the BxPC-3 pancreatic cancer cell line was detected, and the status of ubiquitinated gelsolin is related to lymph node metastasis of pancreatic cancer. Wu et al [16] found the abnormal activation of ubiquitin-proteasome pathway accelerated the degradation of I kappa B alpha to increase NF-kappa B expression in gastric carcinoma tissues, which was significantly associated with the increase of lymph node metastasis. Therefore, we thought that RNF180, as a member of E3 ubiquitin ligases, might take part in above molecular events to promote the lymph node metastasis from gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer

et al. 2014

View full text Add to dashboard Cite

RNF 180, a novel tumor suppressor, has been implicated in the carcinogenesis and progress of gastric cancer. At present study, we found that lower expression of RNA180 was specific in gastric cancer tissues, and the inconsistently methylated levels of RNF180 promoter were identified in the gastric cancer tissues. Importantly, we demonstrated that the methylated CpG site count and four hypermethylated CpG sites (−116, −80, +97, and +102) were significantly associated with the survival of 400 gastric cancer patients, respectively. With multivariate survival analyses, we demonstrated that both the methylation of combined CpG (−116, −80, +97, and +102) sites and N stage were the independent indictor of prognosis of gastric cancer patients. Eventually, the methylation of combined CpG (-116, -80, +97, and +102) sites was identified to have smaller AIC value than N stage by mean of AIC calculation with the Cox proportional hazards model. These findings indicated that the quantitative detection of RNF180 promoter methylation had the intensive feasibility for evaluation the prognosis of gastric cancer patients in clinic.

show abstract

“…Yuan et al has found that OLC1 was associated with activation of NF-κB signaling pathway [4]. Constitutive activation of NF-κB was detected in gastric tumors before and is closely intertwined with cancer growth and metastasis [12–14]. The activation of NF-κB is an early event during tumorigenesis, which can regulate expression of multiple genes involved in carcinoma formation, progression and invasion thereafter [15–17].…”

Section: Discussionmentioning

confidence: 99%

Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma

Wang

Shen

et al. 2016

Oncotarget

View full text Add to dashboard Cite

We have performed this retrospective study to elucidate whether elevated expression of the overexpressed in lung cancer 1 (OLC1) was related to the clinicopathological parameters and prognosis of patients with gastric adenocarcinoma.Additionally, different effects of various subcellular OLC1 expression on gastric adenocarcinogenesis were focused on in our study. Both overall and subcellular expression of OLC1 was evaluated by immunohistochemistry(IHC) via tissue microarrays from total 393 samples. The Kaplan-Meier method and Cox's proportional hazard model were exerted to further explore the correlation between OLC1 and prognosis. Total overexpression of OLC1 was significantly associated with stage (P = 0.004) and differentiation (P = 0.009), and only the strong total expression could predict a poor prognosis (HR = 1.31, P = 0.04). There were significant associations found between nuclear overexpression and tumor invasion depth(P = 0.002), lymph node (P < 0.001), stage (P = 0.004), differentiation (P < 0.001) and smoking history (P = 0.045). Furthermore, over-expressed nuclear OLC1 protein could be an independent risk factor for gastric adenocarcinoma (univariate: HR = 1.43, P = 0.003; multivariate: HR = 1.39, P = 0.011). In general, both total and nuclear overexpression of OLC1 could be the signs of gastric adeno-carcinogenesis, which might be served as the biomarkers for diagnosis at an early stage, even at the onset of tumorigenesis.Rather than the total expression, nuclear overexpression of OLC1 was correlated with most clinicopathological parameters and could predict a poor overall survival as an independent factor for prognosis, which made it a more effective and sensitive biomarker for gastric adenocarcinoma.

show abstract

The ubiquitin‐proteasome pathway and enhanced activity of NF‐κB in gastric carcinoma

Abstract: This study demonstrates that the constitutive activation of NF-kappa B is likely due to the activation of ubiquitin-proteasome pathway and NF-kappa B can be used as a prognostic biomarker.

Cited by 24 publications

References 33 publications

Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells

Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells

Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer

Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma

Contact Info

Product

Resources

About