The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie‐Young; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej; Li, Chunyan; Heldin, Carl‐Henrik; Landström, Maréne

doi:10.1016/j.ebiom.2022.104155

Cited by 9 publications

(3 citation statements)

References 84 publications

(153 reference statements)

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“…Recently, the TGF-β signaling pathway was found to be closely associated with cellular mitosis. According to Song et al [ 31 ], the expression of TGF-β receptor exhibited a strong correlation with both the mitotic spindle and the G2/M checkpoint. Additionally, the formation of a complex between TGF-β receptor and the ubiquitin ligase TRAF6 was discovered to play a role in the advancement of mitosis and cytokinesis in prostate cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Jin,

Lu,

Yang

et al. 2024

Discov Onc

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Background Ankyrin repeat domain 53 (ANKRD53) plays an important role in maintaining chromosome integrity and stability, and chromosome instability is associated with cancer. Through integrative analysis, this study investigates the potential value of ANKRD53 in stomach adenocarcinoma (STAD). Methods RNA-seq and scRNA-seq data were used for integrative analysis based on online databases. Expression of ANKRD53 was confirmed by RT-PCR after bioinformatic analysis. Kaplan–Meier and Cox regression analyses were performed to evaluate the prognostic value of ANKRD53 in STAD. Gene set enrichment analysis (GSEA) was performed to evaluate ANKRD53-related signaling pathways. In addition, the interaction of ANKRD53 with immunity was also investigated. Results RT-PCR in STAD cell lines confirmed that ANKRD53 was downregulated in STAD samples compared to normal samples in the online databases. As an independent predictive biomarker, ANKRD53 was combined with other clinicopathological parameters to create a prognostic nomogram. Using GSEA, ANKRD53 was found to be involved in five pathways, including the TGF-β signaling pathway. Further investigation revealed that ANKRD53 was associated with immune checkpoint molecules, immunological pathways, and immunotherapy, in addition to MSI, TMB and neoantigens. In addition, scRNA-seq data revealed that ANKRD53 is mainly expressed in CD8+ T and dendritic cells. Conclusions ANKRD53 is an important biomarker for STAD that deserves further attention.

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Section: Discussionmentioning

confidence: 99%

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Jin,

Lu,

Yang

et al. 2024

Discov Onc

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“…Additionally, elevated levels of transforming growth factor β (TGFβ) have been observed in certain advanced cancers, contributing to tumor progression. AURKB can form a complex with TGFβ receptor (TβR), known as the AURKB-TβRI complex, which correlates with the malignancy of PCa and serves as a potential prognostic biomarker for patients at risk of developing aggressive PCa [ 62 ]. Addepalli et al demonstrated that the knockdown of AURKB through RNAi inhibited PCa growth in athymic nude mice [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of the cytoplasmic DNA-Sensing cGAS-STING pathway-mediated gene signatures and molecular subtypes in prostate cancer

Yang,

Xu,

Zheng

et al. 2024

BMC Cancer

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Background Considering the age relevance of prostate cancer (PCa) and the involvement of the cGAS-STING pathway in aging and cancer, we aim to classify PCa into distinct molecular subtypes and identify key genes from the novel perspective of the cGAS-STING pathway. It is of significance to guide personalized intervention of cancer-targeting therapy based on genetic evidence. Methods The 430 patients with PCa from the TCGA database were included. We integrated 29 key genes involved in cGAS-STING pathway and analyzed differentially expressed genes and biochemical recurrence (BCR)-free survival-related genes. The assessments of tumor stemness and heterogeneity and tumor microenvironment (TME) were conducted to reveal potential mechanisms. Results PCa patients were classified into two distinct subtypes using AURKB, TREX1, and STAT6, and subtype 1 had a worse prognosis than subtype 2 (HR: 21.19, p < 0.001). The findings were validated in the MSKCC2010 cohort. Among subtype 1 and subtype 2, the top ten mutation genes were MUC5B, DNAH9, SLC5A10, ZNF462, USP31, SIPA1L3, PLEC, HRAS, MYOM1, and ITGB6. Gene set variation analysis revealed a high enrichment of the E2F target in subtype 1, and gene set enrichment analysis showed significant enrichment of base excision repair, cell cycle, and DNA replication in subtype 1. TME evaluation indicated that subtype 1 had a significantly higher level of T cells follicular helper and a lower level of plasma cells than subtype 2. Conclusions The molecular subtypes mediated by the cGAS-STING pathway and the genetic risk score may aid in identifying potentially high-risk PCa patients who may benefit from pharmacologic therapies targeting the cGAS-STING pathway.

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“…Commonly utilized drugs currently include α1-adrenergic receptor blockers, 5α-reductase inhibitors, and β3-adrenergic receptor agonists. TRAF6 is an imperative signal transduction protein in the IGF1-Akt/mTOR signaling, which can respond to cytokine and growth factor signals and regulate the activity of the signaling (Song et al, 2022; O n l i n e F i r s t A r t i c l e Schagdarsurengin et al, 2022). In BPH, overexpression of TRAF6 can sustain the activation of the IGF1-Akt/ mTOR signaling, thereby promoting cell proliferation and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus rhamnosus GG Supplementation on the Growth Performance, Survival rate and Morphometry of Grass Carp (Ctenopharyngodon idella)

Farooq¹

2023

PJZ

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The objective of this study was to demonstrate the effect of ubiquitin ligase tumor necrosis factor receptorassociated factor 6 (TRAF6) on promoting proliferation (Pro) of prostate transitional zone (TZ) and peripheral zone (PZ) cells by activating the insulin-like growth factor 1-protein kinase/mammalian target of rapamycin (IGF1-Akt/mTOR) signaling, providing a research basis for benign prostatic hyperplasia (BPH) therapy. In vitro proliferative prostate tissue specimens from patients with BPH were collected and classified into PZ and TZ tissues. A TRAF6 interference lentivirus was utilized to measure the expression levels of IGF1 and TRAF6 in the prostatic tissue matrix. The impact of TRAF6 on cell growth in the matrix of TZ and PZ tissues was analyzed, the TRAF6 level in the matrix of TZ and PZ tissues was explored, and its role in the phosphorylation process under growth factor stimulation was demonstrated. IGF1 and TRAF6 levels in the matrix of TZ tissue were superior to those in PZ tissue. After TRAF6 expression was inhibited, the Pro activity of TZ matrix cells slowed down, while after it was enhanced, the Pro activity of PZ matrix cells was dramatically increased. The TRAF6 in the inhibition group of TZ tissue was greatly lower, while that in the enhancement group of PZ tissue was greatly higher. It was concluded that TRAF6 promotes Pro of prostate TZ and PZ cells by activating the IGF1-Akt/mTOR signaling.

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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Cited by 9 publications

References 84 publications

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Identification of the cytoplasmic DNA-Sensing cGAS-STING pathway-mediated gene signatures and molecular subtypes in prostate cancer

Effect of Lactobacillus rhamnosus GG Supplementation on the Growth Performance, Survival rate and Morphometry of Grass Carp (Ctenopharyngodon idella)

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