The ubiquitin hydrolase, USP22 contributes to 3’-end processing of JAK-STAT inducible genes

Chipumuro, Edmond; Henriksen, Melissa A.

doi:10.1186/1756-8935-6-s1-p27

Cited by 3 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, USP22 knockdown decreases cell proliferation in several cancer cell lines [53,58,59]. However, while USP22 is capable of deubiquitinating H2B in vitro [36,53,60] and USP22 knockdown increases H2Bub1 levels on the IRF1 gene [18], none of the published reports demonstrated a significant change in global H2Bub1 levels following USP22 knockdown. This is particularly surprising since knockdown of the SAGA DUB module component ATXN7L3 significantly increases global and gene associated H2Bub1 levels [60].…”

Section: H2b Dubsmentioning

confidence: 94%

“…Interestingly, while H2Aub1 serves to repress Hox genes, H2Bub1 is required for active Hox gene transcription [11]. Furthermore, H2Bub1 and H2Aub1 not only play roles in transcription, but also have functions in other DNA‐associated processes such as DNA repair [12–17] as well as mRNA processing [18–20] and transport [21].…”

Section: Histone Modificationsmentioning

confidence: 99%

“…While this may be true in some cases, other genes appear to be regulated in a different manner. For example, induction of the interferon‐regulated gene IRF1 is decreased following USP22 knockdown [18] while knockdown of RNF20 increases IRF1 induction [38]. Thus, for the IRF1 gene, these two enzymes play opposing roles during the induction of transcription.…”

Section: H2bub1 and Nuclear Hormone Receptor Activitymentioning

confidence: 99%

“…Furthermore, given the rapid nature of ubiquitination and deubiquitination of H2B, the presence alone of H2Bub1 on the chromatin (i.e., observed during ChIP analyses) may not necessarily be indicative of where it is primarily functioning. Genome‐wide studies similar to the individual gene studies by Chipumoro and Henriksen [18] comparing the localization of H2Bub1 with H2B deubiquitinating enzymes (DUBs) such as USP22, and the effects of depleting these will be important for determining how dynamic changes in H2Bub1 control gene expression. Furthermore, additional studies to determine the contribution of these enzymes to mRNA processing and transport will be essential for understanding their biological functions.…”

Section: Nucleosome Stabilizer or Chromatin Opener?mentioning

confidence: 99%

See 3 more Smart Citations

The enigmatic role of H2Bub1 in cancer

Johnsen

2012

FEBS Letters

View full text Add to dashboard Cite

Edited by Wilhelm JustKeywords: H2B Monoubiquitination Chromatin Tumor suppressor Cancer Epigenetic a b s t r a c tThe post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclindependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge for the treatment of cancer.Ó 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. Histone modificationsEpigenetic modifications are essential in controlling DNA associated processes such as cell type-specific gene expression, DNA replication and DNA repair. While much focus has been placed on DNA methylation, post-translational modifications of core histones also play an essential, but only poorly understood role in these processes. Chromatin is the composite of packaged nuclear DNA with its associated proteins. The basic unit of chromatin is the nucleosome containing approximately 147 bp of DNA wrapped around an octamer containing two each of histones H2A, H2B, H3 and H4. Histone octamers are then packaged into higher order chromatin structures by the interactions between individual nucleosomes and the binding of other proteins such as the linker histone H1, heterochromatin protein 1 (HP1), etc. Each of the core histones can be modified by a number of post-translational modifications such as the methylation of arginine and lysine residues, acetylation of lysine residues and phosphorylation of serine or threonine residues. Modifications of the core histones have been hypothesized to make up a ''histone code'' which controls DNAassociated processes in different ways according to the repertoire of modifications present at a given chromatin region [1,2]. Furthermore, a number of other post-translational modifications of histones such as formylation [3,4], sumoylation [5], crotonylation[6], ADP-ribosylation [7], etc., have been identified, but their functions remain mostly enigmatic.In addition to the more common modifications like methylation, acetylation ...

show abstract

Section: H2b Dubsmentioning

confidence: 94%

Section: Histone Modificationsmentioning

confidence: 99%

Section: H2bub1 and Nuclear Hormone Receptor Activitymentioning

confidence: 99%

Section: Nucleosome Stabilizer or Chromatin Opener?mentioning

confidence: 99%

See 2 more Smart Citations

The enigmatic role of H2Bub1 in cancer

Johnsen

2012

FEBS Letters

View full text Add to dashboard Cite

show abstract

“…USP22 is responsible to stabilize many cancer‐related proteins by targeting through deubiquitination and influences oncogene accumulation . Two histone proteins H2A and H2B are deubiquitinated by USP22 which further stabilizes AR (Figure ) . In addition, without the presence of ligand, USP22 also can promote AR binding, AR‐dependent transcription, and gene signatures associated with CRPC that proved castrate‐resistant AR activity of USP22 …”

Section: Dubs For Regulating Androgen Receptor Signalling Pathwaymentioning

confidence: 99%

Targeting the signalling pathways regulated by deubiquitinases for prostate cancer therapeutics

Islam

Zhou

Chen

et al. 2019

Cell Biochemistry & Function

View full text Add to dashboard Cite

Prostate cancer (PCa) is the most common cancer diagnosed and the second most common cause of cancer‐related death in men worldwide. The current androgen deprivation therapy for PCa cannot fully cure this disease. Moreover, androgen receptor gene amplification and mutation are associated with PCa to develop castration‐resistant prostate cancer (CRPC). This review focuses on the deubiquitinases (DUBs) involved in PCa development and progression. For PCa development and progression, several cellular pathways are regulated by specific DUBs which are also highlighted in here. The ubiquitin‐specific proteases (USPs), a family member of DUBs mostly involved in the regulation of cellular pathways for PCa development, and the ubiquitin C‐terminal hydrolases (UCHs), another family member of DUBs, are responsible for PCa metastasis. Small molecular inhibitors against DUBs can inhibit or reduce the level of specific DUBs through the regulation of cellular pathway to treat this disease. Some small molecular inhibitors are already identified against some of the DUBs, but very few of them are clinically proved in PCa. So, to find out other DUBs involving in the regulation of PCa‐related pathways and to develop more effective small molecule inhibitors with greater potency would be a great idea to target PCa cells for future therapeutics and drug development with or without the combination of other anticancer drugs. Significance of the study This review is targeting DUB proteins which are responsible for PCa induction, proliferation, and metastasis by highlighting their signalling pathway so that the readers can get information about other mechanisms for PCa besides androgen receptor pathway and helps to find other oncogenic DUBs involving in these signalling pathways. This review also hopes to find other oncogenic DUBs involving in PCa‐related signalling pathways or to find the DUBs that can regulate multiple oncogenic signalling pathways which might be a good target for PCa therapeutics. In addition, there are some small molecule inhibitors that can inhibit the oncogenic DUBs and thus able to control the oncogenic pathways which would be a novel strategy to treat CRPC by using DUB inhibitor combined with or without other anticancer drugs.

show abstract

Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes

et al. 2016

View full text Add to dashboard Cite

Post-translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are the major cellular processes used to balance the protein turnover of several transcription factors that regulate stem cell differentiation. Deubiquitinating enzymes (DUBs), which facilitate the processing of ubiquitin, significantly influence stem cell fate choices. Specifically, DUBs play a critical regulatory role during development by directing the production of new specialized cells. This review focuses on the regulatory role of DUBs in various cellular processes, including stem cell pluripotency and differentiation, adult stem cell signaling, cellular reprogramming, spermatogenesis, and oogenesis. Specifically, the identification of interactions of DUBs with core transcription factors has provided new insight into the role of DUBs in regulating stem cell fate determination. Thus, DUBs have emerged as key pharmacologic targets in the search to develop highly specific agents to treat various illnesses. STEM CELLS 2017;35:9-16 SIGNIFICANCE STATEMENTThe review is written from a unique perspective in overseeing the regulatory role of deubiquitinating enzymes in stem cells. A great attention has been given to the physiological role of ubiquitination system in regulating pluripotency of embryonic stem cells. However, the reversal of ubiquitination by deubiquitinating enzymes plays an equally important role in the regulation of levels of expression of the stemness-related proteins by preventing its ubiquitination. This is timely topic, given that this is the first review article attempting to discuss the accumulated evidence suggesting the critical role of deubiquitinating enzymes in regulating stem cell fate determination process such as maintenance of pluripotency, differentiation, cellular reprogramming, spermatogenesis, and oogenesis. Beyond this, the review provide us the clue for the remaining challenges in developing DUBs as targets for stem cell therapeutics.

show abstract

The ubiquitin hydrolase, USP22 contributes to 3’-end processing of JAK-STAT inducible genes

Abstract: The ubiquitin hydrolase, USP22 contributes to 3'-end processing of JAK-STAT inducible genes.

Cited by 3 publications

References 0 publications

The enigmatic role of H2Bub1 in cancer

The enigmatic role of H2Bub1 in cancer

Targeting the signalling pathways regulated by deubiquitinases for prostate cancer therapeutics

Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes

Contact Info

Product

Resources

About