The Ubiquitin-Associated and SH3 Domain-Containing Proteins (UBASH3) Family in Mammalian Development and Immune Response

Abstract

UBASH3A and UBASH3B are protein families of atypical protein tyrosine phosphatases that function as regulators of various cellular processes during mammalian development. As UBASH3A has only mild phosphatase activity, its regulatory effects are based on the phosphatase-independent mechanisms. On the contrary, UBASH3B has strong phosphatase activity, and the suppression of its receptor signalling is mediated by Syk and Zap-70 kinases. The regulatory functions of UBASH3A and UBASH3B are particularly evident in the lymphoid tissues and kidney development. These tyrosine phosphatases are also known to play key roles in autoimmunity and neoplasms. However, their involvement in mammalian development and its regulatory functions are largely unknown and are discussed in this review.

Role of Tula-Family Proteins in Cell Signaling and Activation: Advances and Challenges

“…The review by Vukojevic et al [39] expands the discussion of the role of UBASH3 proteins into the realm of individual development. Although this role of the UBASH3 family remains insufficiently understood, some recent data [11] strongly suggest that UBASH3A acts as a regulator of renal development and a viability factor in renal cells, possibly through its interactions with Syk [39], a rather ubiquitous PTK that plays a key role in many biological processes.…”