The U.S. National Library of Medicine’s Toxicology and Environmental Health Information Program

Wexler, Philip

doi:10.1016/j.tox.2004.01.037

Cited by 33 publications

(11 citation statements)

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“…Yet their inclusion in a toxin database like T3DB would be certainly stretch the limits of believability. Therefore we chose to further refine the inclusion criteria to limit ourselves to those compounds that have been routinely identified as hazardous in relatively low concentrations (<1 mM for some, <1 µM for others) and which appear on multiple toxin/poison lists provided by government agencies such as TOXNET (12) or the toxicological and medical literature. In each case, the toxicity of each compound was assessed by examining the available toxicity measurements and health effects, such as minimum lethal dose, LD50, LC50 values and carcinogenicity.…”

Section: Criteria For Inclusion In T3dbmentioning

confidence: 99%

T3DB: a comprehensively annotated database of common toxins and their targets

Lim

Pon

Djoumbou

et al. 2009

Nucleic Acids Research

129

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In an effort to capture meaningful biological, chemical and mechanistic information about clinically relevant, commonly encountered or important toxins, we have developed the Toxin and Toxin-Target Database (T3DB). The T3DB is a unique bioinformatics resource that compiles comprehensive information about common or ubiquitous toxins and their toxin-targets into a single electronic repository. The database currently contains over 2900 small molecule and peptide toxins, 1300 toxin-targets and more than 33 000 toxin-target associations. Each T3DB record (ToxCard) contains over 80 data fields providing detailed information on chemical properties and descriptors, toxicity values, protein and gene sequences (for both targets and toxins), molecular and cellular interaction data, toxicological data, mechanistic information and references. This information has been manually extracted and manually verified from numerous sources, including other electronic databases, government documents, textbooks and scientific journals. A key focus of the T3DB is on providing ‘depth’ over ‘breadth’ with detailed descriptions, mechanisms of action, and information on toxins and toxin-targets. T3DB is fully searchable and supports extensive text, sequence, chemical structure and relational query searches, similar to those found in the Human Metabolome Database (HMDB) and DrugBank. Potential applications of the T3DB include clinical metabolomics, toxin target prediction, toxicity prediction and toxicology education. The T3DB is available online at http://www.t3db.org.

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Section: Criteria For Inclusion In T3dbmentioning

confidence: 99%

T3DB: a comprehensively annotated database of common toxins and their targets

Lim

Pon

Djoumbou

et al. 2009

Nucleic Acids Research

129

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“…For further investigation on the potential occupational nature of a disease physicians should subsequently refer to the online database of the National Library of Medicine's Toxicology and Environmental Health Information Program (TEHIP). TEHIP is a relevant portal reporting extensive toxicological information worldwide, including several scientifically peer-reviewed databases residing within the web-based TOXNET system [25]. Haz-Map is one of these occupational toxicology databases available on the National Library of Medicine's TOXNET system.…”

Section: Discussionmentioning

confidence: 99%

The Primary Care Practitioner and the diagnosis of occupational diseases

Cegolon

Lange²,

Mastrangelo

2010

BMC Public Health

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BackgroundRather than a clinical diagnosis, in occupational medicine the critical point is the etiological diagnosis. The first is useful for the therapy, the latter for preventive, epidemiological, regulatory, and insurance measures.DiscussionAs with causality criteria which are employed in population studies, the answering of four easy questions allows a Primary Care Practitioner to establish a causal link between the work activities and a potential disease that a specific patient may present.After determining the clinical diagnosis and the actual pathology of an occupational disease, the identity, duration, and intensity of the exposure have to be detected for establishing a close-causal effect. The judgment on the occupational origin of the disease requires an integrated approach using multiple sources of information, and goes beyond the clinical diagnosis. This may require consultation with a specialist in occupational medicine.SummaryIt is important that the Primary Care Practitioner takes an accurate medical history since this may be the only chance a patient has to have their occupational disease recognised and properly detected/identified. Proper identification of the causative nature of such diseases is important for establishing preventive measures in eliminating and controlling future cases against exposure, epidemiological reporting and studies (particularly in identifying the rates of disease), regulatory reporting requirements and insurance compensation.

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“…As well, CTD datasets have been used by several independent groups for meta-analyses to derive relationships between environmental chemicals and complex human diseases (18–20). Furthermore, CTD will be included as a search option in the suite of integral databases at TOXNET, the National Library of Medicine’s portal for toxicology data (21). …”

Section: Introductionmentioning

confidence: 99%

The Comparative Toxicogenomics Database: update 2011

Davis

King

Mockus

et al. 2010

Nucleic Acids Research

263

258

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The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. Biocurators at CTD manually curate a triad of chemical–gene, chemical–disease and gene–disease relationships from the literature. These core data are then integrated to construct chemical–gene–disease networks and to predict many novel relationships using different types of associated data. Since 2009, we dramatically increased the content of CTD to 1.4 million chemical–gene–disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps (to find comparable genes and chemicals that share toxicogenomic profiles), enriched Gene Ontology terms associated with chemicals, statistically ranked chemical–disease inferences, Venn diagram tools to discover overlapping and unique attributes of any set of chemicals, genes or disease, and enhanced gene pathway data content, among other features. Together, this wealth of expanded chemical–gene–disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org.

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The U.S. National Library of Medicine’s Toxicology and Environmental Health Information Program

Cited by 33 publications

References 0 publications

T3DB: a comprehensively annotated database of common toxins and their targets

T3DB: a comprehensively annotated database of common toxins and their targets

The Primary Care Practitioner and the diagnosis of occupational diseases

The Comparative Toxicogenomics Database: update 2011

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