Biochemical Pharmacology volume 82, issue 2, P184-194 2011 DOI: 10.1016/j.bcp.2011.04.008 View full text
Tzu-Ching Kuo, Hsing-Pang Lu, Chuck C.-K. Chao

Abstract: The hepatoma upregulated protein (HURP) represents a putative oncogene that is overexpressed in many human cancers, especially hepatocellular carcinoma (HCC). HURP plays an important role during mitotic spindle formation, a process that is targeted by various anti-cancer drugs like taxol. However, the role of HURP during the establishment of taxol chemoresistance in HCC remains unclear. In this study, we observed that high HURP protein level correlates with taxol resistance in HCC cells. Following HURP knockdo…

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