The type of exercise most beneficial for quality of life in people with multiple sclerosis: A network meta-analysis

Reina‐Gutiérrez, Sara; Cavero‐Redondo, Iván; Martínez‐Vizcaíno, Vicente; Arenas‐Arroyo, Sergio Núñez de; López-Muñoz, Purificación; Álvarez‐Bueno, Celia; Guzmán-Pavón, María José; Torres‐Costoso, Ana

doi:10.1016/j.rehab.2021.101578

Cited by 20 publications

(21 citation statements)

References 37 publications

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“…Referring to the classification methods of Luan et al, Gutiérrez et al, we divided physical exercise intervention into the following 6 categories 17 , 18 Aerobic exercises (exercise designed to increase energy expenditure and increase heart rate, including endurance training, cycling, brisk walking, etc. ), Mind-body exercises (MBE, a form of exercise that combines movement, concentration, and breath control while simultaneously taking care of the mental and physical.…”

Section: Methodsmentioning

confidence: 99%

Effect of Exercise Interventions on Health-Related Quality of Life in Patients with Fibromyalgia Syndrome: A Systematic Review and Network Meta-Analysis

Zhang¹,

Wang²,

Zhang³

et al. 2022

JPR

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Objective Several guidelines highlight the beneficial impact of exercise on the management of symptoms and health-related quality of life (HRQOL) in patients with fibromyalgia syndrome (FMS). However, few analyses have compared different types of exercise. We, therefore, intent to compare the effects of different exercise types on improving the overall HRQOL and typical symptoms in patients with FMS. Methods Medline, Embase, the Cochrane Register of Clinical Trials, and NIH ClinicalTrials.gov were searched from inception to April 21, 2022. Randomized clinical trials (RCTs) were included to assess the impact of exercise intervention on health parameters in adult FMS patients. Data were extracted independently and a frequentist network meta-analyses (NMA) was performed to rank the effects of interventions according to P-scores. The NMA evidence certainty was assessed using the method recommended by Grading of Recommendations Assessment, Development, and Evaluation Working Group. Results A total of 57 RCTs were identified, including 3319 participants, involving 9 interventions (7 types of exercise, 2 controls). Of all treatments compared with usual care in efficacy outcomes, Mind-body exercise was associated with the best HRQOL (SMD, −12.12; 95% CI, −15.79 to −8.45). On the other characteristic symptom dimensions, based on moderate quality evidence, sensorimotor training was associated with minimal pain scores compared with usual care (SMD, −1.81; 95% CI, −2.81 to −0.82), whole body vibration therapy was most promising for improving sleep quality (SMD, −6.95; 95% CI, −10.03 to −3.87), pool-based aerobic exercise was most likely to ease anxiety (SMD, −4.83; 95% CI, −7.47 to −2.19), and whole body vibration was most likely to improve depression (SMD, −10.44; 95% CI, −22.00 to 1.12). Conclusion Mind-body exercise seems to be the most effective exercise to improve the overall HRQOL of patients with FMS. But at the same time, clinicians still need to develop individualized exercise plans for patients according to their symptoms and accessibility.

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Section: Methodsmentioning

confidence: 99%

Effect of Exercise Interventions on Health-Related Quality of Life in Patients with Fibromyalgia Syndrome: A Systematic Review and Network Meta-Analysis

Zhang¹,

Wang²,

Zhang³

et al. 2022

JPR

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“…Physical activity is recommended for patients with MS because there is ample evidence that physical activity improves muscle function, aerobic fitness, and mobility. Meta-analysis and systematic studies have shown that individuals with MS who engage in exercise and lifestyle activities (including physical activities) experience an improvement in quality of life (34)(35)(36), and exercise could enhance their quality of life (37). Citak et al (23) found that Kegel exercises positively influenced women's sexual function.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis

Ahani

Chorami

Sharifi

et al. 2022

J Shahrekord Univ Med Sci

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Background and aims: The present study aimed to determine the effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis (MS). Methods: In this quasi-experimental study, among women with MS in Isfahan province who had medical records in Ayatollah Kashani Hospital and Isfahan MS Center, 150 female patients were enrolled by convenience sampling and screened by Sexual Quality of Life-Female (SQOL-F). After screening, 46 patients, whose quality of sexual life score was lower than the mean score of 63, were randomly assigned to experimental and control groups, each comprising 23 patients. The experimental group received the Pythagorean self-awareness intervention, while the control group received no intervention. Both groups were assessed at pre-test, post-test, and two follow-up stages. The data were analyzed by multivariate analysis of covariance (MANCOVA). Results: The results revealed that the quality of sexual life of the experimental group improved after the intervention (P<0.001). Compared to the pre-test, a significant difference was observed in its components, namely, psychosexual feelings, sexual and relationship satisfaction, self-worthlessness, and sexual repression (P<0.001). Conclusion: It seems that Pythagorean self-awareness intervention effectively improves the quality of sexual life of women with MS. In addition to the overall improvement in the quality of sexual life, a significant difference was observed in its components compared to the pre-test after the intervention. Therefore, it is essential to plan psychological interventions to improve these women’s quality of sexual life.

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“…Despite the broad literature on the effects of different types of exercises on the neuroplasticity in people with RRMS [ 37 , 48 – 50 ], it is unclear whether in-phase bilateral exercises can promote motor related neuroplastic changes in RRMS. In light of evidence that people with RRMS have bilateral cortical lesions [ 51 ] which cause bilateral changes of corticospinal tract integrity [ 21 , 23 ], these findings raise the question about the effects of in-phase bilateral exercises on corticospinal plasticity.…”

Section: Introductionmentioning

confidence: 99%

Investigation of in-phase bilateral exercise effects on corticospinal plasticity in relapsing remitting multiple sclerosis: A registered report single-case concurrent multiple baseline design across five subjects

et al. 2023

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Relapsing-remitting Multiple Sclerosis is the most common demyelinating neurodegenerative disease and is characterized by periods of relapses and generation of various motor symptoms. These symptoms are associated with the corticospinal tract integrity, which is quantified by means of corticospinal plasticity which can be probed via transcranial magnetic stimulation and assessed with corticospinal excitability measures. Several factors, such as exercise and interlimb coordination, can influence corticospinal plasticity. Previous work in healthy and in chronic stroke survivors showed that the greatest improvement in corticospinal plasticity occurred during in-phase bilateral exercises of the upper limbs. During in-phase bilateral movement, both upper limbs are moving simultaneously, activating the same muscle groups and triggering the same brain region respectively. Altered corticospinal plasticity due to bilateral cortical lesions is common in MS, yet, the impact of these type of exercises in this cohort is unclear. The aim of this concurrent multiple baseline design study is to investigate the effects of in-phase bilateral exercises on corticospinal plasticity and on clinical measures using transcranial magnetic stimulation and standardized clinical assessment in five people with relapsing-remitting MS. The intervention protocol will last for 12 consecutive weeks (30–60 minutes /session x 3 sessions/week) and include in-phase bilateral movements of the upper limbs, adapted to different sports activities and to functional training. To define functional relation between the intervention and the results on corticospinal plasticity (central motor conduction time, resting motor threshold, motor evoked potential amplitude and latency) and on clinical measures (balance, gait, bilateral hand dexterity and strength, cognitive function), we will perform a visual analysis and if there is a potential sizeable effect, we will perform statistical analysis. A possible effect from our study, will introduce a proof-of-concept for this type of exercise that will be effective during disease progression. Trial registration: ClinicalTrials.gov NCT05367947.

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The type of exercise most beneficial for quality of life in people with multiple sclerosis: A network meta-analysis

Cited by 20 publications

References 37 publications

Effect of Exercise Interventions on Health-Related Quality of Life in Patients with Fibromyalgia Syndrome: A Systematic Review and Network Meta-Analysis

Effect of Exercise Interventions on Health-Related Quality of Life in Patients with Fibromyalgia Syndrome: A Systematic Review and Network Meta-Analysis

The effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis

Investigation of in-phase bilateral exercise effects on corticospinal plasticity in relapsing remitting multiple sclerosis: A registered report single-case concurrent multiple baseline design across five subjects

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