The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19

Suzzi, Stefano; Tsitsou-Kampeli, Afroditi; Schwartz, Michal

doi:10.1038/s41590-022-01410-z

Cited by 19 publications

(22 citation statements)

References 34 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though the CNS has immune privilege, neuroimmune responses could still occur after infection. However, the underlying mechanism of neuroimmune response post SARS-CoV-2 infection is very complex, including CD8+ T cell and microglia infiltration 40 , complement system activation 40,41 , IFN-I and proinflammatory signaling pathways initiation 42 . Marius Schwabenland et.al 43 provided direct evidence of microglial and T cell infiltration in COVID-19 patients' brain sections, furthermore, the microglia-T-cell interaction is tightly associated with neuroinflammatory parameters.…”

Section: Discussionmentioning

confidence: 99%

SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

Qiao,

Deng,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

The coronavirus disease of 2019 (COVID-19) pandemic that has led to more than 700 million confirmed cases and near 7 million deaths. Although Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus mainly infects the respiratory system, neurological complications are widely reported in both acute infection and long-COVID cases. Despite the success of vaccines and antiviral treatments, neuroinvasiveness of SARS-CoV-2 remains as an important question, which is also centered on the mystery whether the virus is capable of breaching the barriers into the central nervous system. By studying the K18-hACE2 infection model, we observed clear evidence of microvascular damage and breakdown of the blood-brain barrier (BBB). Mechanistically, SARS-CoV-2 infection caused pericyte damage, tight junction loss, endothelial activation and vascular inflammation, which together drive microvascular injury and BBB impairment. In addition, the blood-cerebrospinal fluid barrier at the choroid plexus was also impaired after infection. Therefore, cerebrovascular and choroid plexus dysfunctions are important aspects of COVID-19 and may contribute to the neurological complications both acutely and in long COVID.

show abstract

Section: Discussionmentioning

confidence: 99%

SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

Qiao,

Deng,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In our study, it is unclear if CD8+ T cells enter the brain parenchyma through the mouse CSF, and where potential expansion may occur. The choroid plexus epithelium forms the barrier between the brain parenchyma and the CSF and has been identified as a source of Type I IFN signaling, as well as a key site of lymphocyte infiltration (Suzzi et al, 2023). Investigation of cytokine signaling networks and their role in T cell entry into the AD brain are needed in future studies.…”

Section: Discussionmentioning

confidence: 99%

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

Fernando

Gopalakrishnan

Behensky

et al. 2023

Preprint

View full text Add to dashboard Cite

Alzheimer′s disease (AD) is the leading cause of dementia worldwide, but there are limited therapeutic options and no current cure. While the involvement of microglia in AD has been highly appreciated, the role of other innate and adaptive immune cells remains largely unknown, partly due to their scarcity and heterogeneity. This study aimed to study non-microglial immune cells in wild type and AD-transgenic mouse brains across different ages. Our results uncovered the presence of a unique CD8+ T cell population that were selectively increased in aging AD mouse brains, here referred to as ″disease-associated T cells (DATs)″. These DATs were found to express an elevated tissue-resident memory and Type I interferon-responsive gene signature. Further analysis of aged AD mouse brains showed that these CD8+ T cells were not present in peripheral or meningeal tissues. Preventing CD8+ T cell development in AD-transgenic mice via genetic deletion of beta-2 microglobulin (B2m) led to a reduction of amyloid-β ; plaque formation in aged mice, and improved memory in AD-transgenic mice as early as four months of age. The integration of transcriptomic and epigenomic profiles at the single-cell level revealed potential transcription factors that reshape the regulomes of CD8+ T cells. These findings highlight a critical role for DATs in the progression of AD and provide a new avenue for treatment.

show abstract

“…261,269 Choroid plexus function has also been linked to cognition. 271 The function of the choroid plexus and the BCSFB is altered during hypertension. For example, transport of water across the choroid plexus was reduced by about one-third in SHRs compared with normotensive controls.…”

Section: Compendium: Circadian Mechanisms In Cardio/ Cerebrovascular ...mentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

View full text Add to dashboard Cite

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

show abstract

The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19

Cited by 19 publications

References 34 publications

SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Contact Info

Product

Resources

About