The Type I and Type II Receptor Complexes for IL-4 and IL-13 Differentially Regulate Allergic Lung Inflammation

Heller, Nicola; Dasgupta, Preeta; Dorsey, Nicolas; Chapoval, Svetlana P.; Keegan, Achsah

doi:10.5772/25650

Cited by 3 publications

(3 citation statements)

References 239 publications

(185 reference statements)

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“…The intracellular signaling pathways of the differing receptor types are slightly different. Whereas dimerization of the type I receptor results in the activation of receptor associated Janus Kinases of the types JAK1, JAK2 and JAK3, the type 2 receptor complex is characterized by the activation of JAK1, JAK2 and Tyk3 (Heller, 2012).…”

Section: The Il-4/il-13 Receptor Complexmentioning

confidence: 99%

“…One theory suggests that the different biological functions of IL-4 and IL-13 are caused by different affinities of the cytokines to the IL-4 receptor-α chain and the IL-13 receptorα1 chain. Additionally, it is thought that the differences are caused by varying relative abundances of type I and type II receptor complexes on different cell types (Heller, 2012). More recent studies could prove that IL-4 and IL-13 are actually able to induce different intracellular signaling pathways via binding to the same type II receptor heterodimer (LaPorte et al., 2008).…”

Section: The Il-4/il-13 Receptor Complex As Therapeutic Targetmentioning

confidence: 99%

“…The IL-4/IL-13 receptor complex -The figure is adapted fromHeller, 2012 IL-4/IL-13 receptor signaling is involved in numerous processes that are decisive for allergic diseases: As mentioned in chapter 1.3, the receptor complex is indispensable for TH2 differentiation, the IgE switch of B cells and the majority of symptoms of allergic inflammation. This miscellaneous panel of biologic functions of the IL-4/IL-13 receptor complex makes it a very attractive therapeutic target in atopic diseases.…”

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confidence: 99%

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Sustained Inhibition of the IL4/IL13 Receptor Complex during Allergen Specific Immunotherapy

Rußkamp¹

2018

Preprint

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Section: The Il-4/il-13 Receptor Complexmentioning

confidence: 99%

Section: The Il-4/il-13 Receptor Complex As Therapeutic Targetmentioning

confidence: 99%

mentioning

confidence: 99%

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Sustained Inhibition of the IL4/IL13 Receptor Complex during Allergen Specific Immunotherapy

Rußkamp¹

2018

Preprint

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Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation

et al. 2018

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Ongoing axonal degeneration is thought to underlie disability in chronic neuroinflammation, such as multiple sclerosis (MS), especially during its progressive phase. Upon inflammatory attack, axons undergo pathological swelling, which can be reversible. Because we had evidence for beneficial effects of T helper 2 lymphocytes in experimental neurotrauma and discovered interleukin-4 receptor (IL-4R) expressed on axons in MS lesions, we aimed at unraveling the effects of IL-4 on neuroinflammatory axon injury. We demonstrate that intrathecal IL-4 treatment during the chronic phase of several experimental autoimmune encephalomyelitis models reversed disease progression without affecting inflammation. Amelioration of disability was abrogated upon neuronal deletion of IL-4R. We discovered direct neuronal signaling via the IRS1-PI3K-PKC pathway underlying cytoskeletal remodeling and axonal repair. Nasal IL-4 application, suitable for clinical translation, was equally effective in improving clinical outcome. Targeting neuronal IL-4 signaling may offer new therapeutic strategies to halt disability progression in MS and possibly also neurodegenerative conditions.

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Cytokines in chronic respiratory diseases

Atamas¹,

Chapoval²,

Keegan³

2013

F1000 Biol Rep

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Cytokines are small, secreted proteins that control immune responses. Within the lung, they can control host responses to injuries or infection, resulting in clearance of the insult, repair of lung tissue, and return to homeostasis. Problems can arise when this response is over exuberant and/or cytokine production becomes dysregulated. In such cases, chronic and repeated inflammatory reactions and cytokine production can be established, leading to airway remodeling and fibrosis with unintended, maladaptive consequences. In this report, we describe the cytokines and molecular mechanisms behind the pathology observed in three major chronic diseases of the lung: asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. Overlapping mechanisms are presented as potential sites for therapeutic intervention.

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The Type I and Type II Receptor Complexes for IL-4 and IL-13 Differentially Regulate Allergic Lung Inflammation

Cited by 3 publications

References 239 publications

Sustained Inhibition of the IL4/IL13 Receptor Complex during Allergen Specific Immunotherapy

Sustained Inhibition of the IL4/IL13 Receptor Complex during Allergen Specific Immunotherapy

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation

Cytokines in chronic respiratory diseases

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