The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis

Gibbons, LJ; Thomson, Wendy; Zeggini, Eleftheria; Worthington, Jane; Barton, Anne; Eyre, Steve; Donn, Rachelle; Hinks, Anne

doi:10.1093/rheumatology/kei041

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…Characteristics of studies included in the current meta‐analysis are presented in Table 1 (Guo et al. , 2004; Gibbons et al. , 2005; Jennings et al.…”

Section: Resultsmentioning

confidence: 99%

“…There were 23 papers relevant to the searching words. Through the step of screening the abstract, 11 of these articles were excluded (7 were review; 4 did not explored SUMO4 gene polymorphism), leaving 12 studies (Gibbons et al. , 2005; Jennings et al.…”

Section: Resultsmentioning

confidence: 99%

“…A number of case–control studies were conducted to investigate the association of this polymorphisms with human autoimmune and inflammatory diseases (Guo et al. , 2004; Gibbons et al. , 2005; Jennings et al.…”

Section: Introductionmentioning

confidence: 99%

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Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta‐analysis

Zou

Feng

Tao

et al. 2010

Int J Immunogenetics

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The purpose of this study was to generate large-scale evidence on whether SUMO4 M55V polymorphism is associated with autoimmune and inflammatory diseases using a meta-analysis. We surveyed studies on the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed for genotypes AG versus AA, GG versus AA, GG versus AA + AG, AG + GG versus AA and G allele versus A allele in a fixed/random effect model. We identified 16 studies (11, 407 cases and 10, 679 controls) using PubMed search. When all groups were pooled, we detected the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases (G versus A: OR = 1.11, 95%CI = 1.03-1.19, P = 0.005; AG +GG versus AA: OR=1.17, 95%CI=1.06-1.28, P=0.001; GG versus AA+AG: OR=1.07, 95%CI=0.94-1.21, P=0.29; GG versus AA: OR=1.15, 95%CI=1.00-1.34, P=0.06; AG versus AA: OR=1.15, 95%CI=1.08-1.23, P<0.0001). In subgroup analyses, we detected the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases in Asian population (G versus A: OR=1.18, 95%CI=1.08-1.28, P=0.0001; AG+GG versus AA: OR=1.30, 95%CI=1.16-1.45, P<0.00001; GG versus AA+AG: OR=1.04, 95%CI=0.78-1.37, P=0.80; GG versus AA: OR=1.20, 95%CI=0.99-1.45, P=0.07; AG versus AA: OR=1.32, 95%CI=1.18-1.49, P<0.00001). But the association was not found in Caucasian population. Meanwhile, an association of SUMO4 M55V polymorphism with autoimmune diabetes was found (G versus A: OR=1.18, 95%CI=1.08-1.30, P=0.0005; AG+GG versus AA: OR=1.22, 95%CI=1.13-1.32, P<0.00001; GG versus AA+AG: OR=1.15, 95%CI=0.96-1.38, P=0.13; GG versus AA: OR=1.32, 95%CI=1.08-1.60, P=0.006; AG versus AA: OR=1.23, 95%CI=1.13-1.33, P<0.00001). This meta-analysis demonstrates the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases, especially in Asian population.

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“…Characteristics of studies included in the current meta‐analysis are presented in Table 1 (Guo et al. , 2004; Gibbons et al. , 2005; Jennings et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta‐analysis

Zou

Feng

Tao

et al. 2010

Int J Immunogenetics

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“…Wang and colleagues have recently reviewed the correlation between SUMO-4 polymorphism and type-I diabetes, and they provided some insights to explain the discrepancy noted among different populations and the mechanisms through which SUMO4 contributes to the pathogenesis of type-I diabetes [211]. SUMO-4 polymorphism seems to have no correlation with susceptibility of other inflammatory conditions including Grave's disease [212], rheumatoid arthritis [213–215], and systemic lupus erythematosus [216]. Finally, it is conceivable that modulation of I κ B α sumoylation may be utilized as a mechanism to aggravate or alleviate the symptoms of various NF- κ B-driven inflammatory conditions.…”

Section: Regulation Of Nf-κb Activity Via Iκbα Sumoylationmentioning

confidence: 99%

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

Majdalawieh

2010

Mediators of Inflammation

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NF-κB comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-κB in inflammation and atherosclerosis and the regulation of the NF-κB signaling pathway are summarized. The structure, function, and regulation of the NF-κB inhibitors, IκBα and IκBβ, are reviewed. The regulation of NF-κB activity by glucocorticoid receptor (GR) signaling and IκBα sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-κB transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-κB via physical interaction with IκBα and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IκBα-interacting proteins play in NF-κB signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.

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“…However, studies in Caucasians involving larger population cohorts failed to show association with either RA [75][76][77] or SLE [78]. Although further well-powered studies are definitely required to replicate the association of SUMO4 with autoimmunity in Japanese, the loss of association in Caucasians may be explained by epistasis between SUMO4 and other loci influencing the direction of the association.…”

Section: Genetic Studies Revealed the Ethnic-specific Association Of mentioning

confidence: 99%

Identification of New Susceptibility Genes for Type 1 Diabetes: An Update

Chistiakov¹,

Voronova²,

Chistiakova³

2008

CIR

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The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis

Abstract: The M55V substitution in the SUMO4 gene is not associated with susceptibility to RA or JIA in the UK population studied. However, other candidate genes mapping within IDDM5 remain to be investigated.

Cited by 13 publications

References 17 publications

Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta‐analysis

Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta‐analysis

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

Identification of New Susceptibility Genes for Type 1 Diabetes: An Update

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