The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic

Hall, Arron F; Wang, Dong V.

doi:10.1016/j.pneurobio.2022.102396

Cited by 7 publications

(5 citation statements)

References 101 publications

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“…Additionally, our results revealed that memory-associated ripples were enlarged in amplitude, contrary to a previous study [27], which may reflect species differences between mice and rats [47]. Together, our findings suggest that elongated and enlarged ripples signify the consolidation of newly acquired memories, while shorter and smaller ripples may indicate baseline activity or preconfigured dCA1 rigid motifs [28].…”

Section: Discussioncontrasting

confidence: 90%

“…Taken together, we propose a model of ripple-associated memory consolidation, as depicted in Figure 2F. During non-memory ripples, most dCA1 neurons exhibit a baseline probability of activation that possibly represents preconfigured rigid motifs [28, 29]. Upon memory consolidation, relevant dCA1 neurons exhibit robust increase and/or prolongation of activity during ripples, while other dCA1 neurons show decrease or no change of activity, which collectively represent specific information coding.…”

Section: Resultsmentioning

confidence: 94%

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Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Liu,

Hall,

Wang

2023

Preprint

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Memories are crucial for our daily lives, yet the network-level organizing principle that governs neural representations of our experiences remains to be determined. Employing dual-site electrophysiology recording in freely behaving mice, we discovered that hippocampal dorsal CA1 (dCA1) and basolateral amygdala (BLA) utilize distinct coding strategies to represent novel experiences. A small assembly of BLA neurons rapidly emerged during memory acquisition and remained active during subsequent consolidation, whereas the majority of dCA1 neurons engaged in the same processes. Machine learning decoding revealed that dCA1 population spikes predicted the BLA assembly firing rate. This suggests that most dCA1 neurons concurrently index an episodic event by rapidly establishing weighted communications with a specific BLA assembly, a process we call “many-to-one weighted mapping.” Furthermore, we demonstrated that closed-loop optoinhibition of BLA activity triggered by dCA1 ripples after new learning resulted in impaired memory. These findings highlight a new principle of hippocampus-amygdala communication underlying memory formation and provide new insights into how the brain creates and stores memories.

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Section: Discussioncontrasting

confidence: 90%

Section: Resultsmentioning

confidence: 94%

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Liu,

Hall,

Wang

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Taken together, we propose a model of ripple-associated memory consolidation, as depicted in Figure 2F. During non-memory ripples, most dCA1 neurons exhibit a baseline probability of activation that possibly represents preconfigured rigid motifs [25]. Upon memory consolidation, relevant dCA1 neurons exhibit robust increase and/or prolongation of activity during ripples, while other dCA1 neurons show decrease or no change of activity, which collectively represent specific information coding.…”

Section: Memory-associated Ripples Are Enlarged and Elongatedmentioning

confidence: 89%

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Wang,

Liu,

Hall

2023

Preprint

View full text Add to dashboard Cite

Memories are crucial for our daily lives, yet the network-level organizing principle that governs neural representations of our experiences remains to be determined. Employing dual-site electrophysiology recording in freely behaving mice, we discovered that hippocampal dorsal CA1 (dCA1) and basolateral amygdala (BLA) utilize distinct coding strategies to represent novel experiences. A small assembly of BLA neurons rapidly emerged during memory acquisition and remained active during subsequent consolidation, whereas the majority of dCA1 neurons engaged in the same processes. Machine learning decoding revealed that dCA1 population spikes predicted the BLA assembly firing rate. This suggests that most dCA1 neurons concurrently index an episodic event by rapidly establishing weighted communications with a specific BLA assembly, a process we call “many-to-one weighted mapping.” Furthermore, we demonstrated that closed-loop optoinhibition of BLA activity triggered by dCA1 ripples after new learning resulted in impaired memory. These findings highlight hippocampus-amygdala communication underlying memory formation and provide new insights into how the brain creates and stores memories.

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“…During SWRs, sequences of place cells are often "replayed" at highly compressed speeds 45,47,87 . This circuit-level phenomenon may elicit plasticity that stabilizes spatial codes 45,46,51,52,88 .…”

Section: Ca1 Stx3 Is Necessary For Offline Consolidation Of Place Codesmentioning

confidence: 99%

Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion

Plitt,

Kaganovsky,

Südhof

et al. 2023

Preprint

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SummaryRapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component of synaptic plasticity. However, it is unknown how this process supports specific neural computations during behavior. To bridge this gap, we combined conditional genetic deletion of a component of the postsynaptic membrane fusion machinery, Syntaxin3 (Stx3), in hippocampal CA1 neurons of mice with populationin vivocalcium imaging. This approach revealed that Stx3 is necessary for forming the neural dynamics that support novelty processing, spatial reward memory and offline memory consolidation. In contrast, CA1 Stx3 was dispensable for maintaining aspects of the neural code that exist presynaptic to CA1 such as representations of context and space. Thus, manipulating postsynaptic membrane fusion identified computations that specifically require synaptic restructuring via membrane trafficking in CA1 and distinguished them from neural representation that could be inherited from upstream brain regions or learned through other mechanisms.

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The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic

Cited by 7 publications

References 101 publications

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion

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