The twin drug approach for novel nicotinic acetylcholine receptor ligands

Tomassoli, Isabelle; Gündisch, Daniela

doi:10.1016/j.bmc.2015.06.034

Cited by 16 publications

(14 citation statements)

References 66 publications

(67 reference statements)

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“…Tomassoli and Gündisch were able to couple 3-bromopyridine 84 and (di)aza(bi)cyclic species 85 in the presence of an L6 -based catalyst ( Scheme 13 b). 93 A solvent mixture composed of toluene and t- BuOH was required to promote solubility of the coupling partners, and microwave heating enhanced C–N bond formation. Prior protection of one nitrogen atom in 85 was necessary to prevent diarylation.…”

Section: Alkylaminesmentioning

confidence: 99%

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

2016

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Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C–N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.

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Section: Alkylaminesmentioning

confidence: 99%

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

2016

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“…According to specific needs and applications, the NCNDs can be modified by postfunctionalization reactions. Herein we report two different reactions that exemplify the surface amine modifications of the NCNDs (A) carbodiimide coupling with molecules bearing carboxylic groups and (B) reductive methylation (Eschweiler-Clarke reaction) 48,49 . Leave the solution to warm-up gradually to r.t. and let it stir overnight, under Ar.…”

Section: Part 2: Post-functionalization and Purification Of Cnds • Timentioning

confidence: 99%

Preparation, functionalization and characterization of engineered carbon nanodots

2019

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Carbon-based Dots (CDs) and their functionalized (nano)composites have recently attracted a lot of attention, owing to their seemingly easy preparation and their numerous potential applications, ranging from biomedical (imaging and drug delivery) to (opto)electronics (i.e., solar cells and LEDs). This protocol covers the synthesis, purification and functionalization of nitrogen-doped carbon nanodots (NCNDs). Firstly, we describe the bottom-up synthesis of NCNCDs by using molecular precursors (arginine and ethylene diamine), through a microwave hydrothermal procedure. We also provide guidelines for the purification of these materials, either through filtration, dialysis or low-pressure size-exclusion chromatography. Secondly, we outline postfunctionalization procedures for the surface modification of NCNDs (such as alkylation and amidation reactions). Thirdly, we provide detailed instructions on the preparation of NCNDs with different properties (such as color emission, electrochemistry and chirality). Given the fast evolution in the preparation and application of CDs, issues that might arise from artifacts, errors and impurities should be avoided. In this context, the present protocol aims at helping synthesize high quality nanomaterials with high reproducibility, for various applications. Furthermore, even if CDs are prepared by different synthetic procedures, as well as from different molecular precursors, they can still be purified and characterized by following this protocol. The sample preparation takes various time frames, ranging from 2 to 12 days depending on the adopted synthesis and purification steps.

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“…In the medicinal chemistry research field Pd(OAc) 2 catalysed coupling reactions in Q-tube were recently reported [26,27]. In one example, the use of such system was required, as the author stated, to reduce the reaction time [27].…”

Section: Catalytic Approachesmentioning

confidence: 99%

“…The hydrodeoxygenation of condensates (26)(27)(28) was accomplished in the liquid phase at 160 °C with 3. catalyst, react. cond.…”

Section: Biofuels Developmentmentioning

confidence: 99%

The Q-tube System, A Nonconventional Technology for Green Chemistry Practitioners

Nacca

Merlino

Mangiavacchi

et al. 2017

CGC

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Background: High-pressure chemistry offers the possibility to have faster and cleaner transformations thus addressing most of the green chemistry principles. Among the devices recently developed, Q-tube is worth mentioning since it is cheap, easy to handle, safe and highly versatile. Methods: The most recent and interesting results obtained using such technique are reviewed in this study. Results: Examples of the Q-tube assisted reactions in organic synthesis are presented in a critical manner making where possible, a comparison with conventional heating strategies and unconventional energy source such as microwave or ultrasounds assisted synthesis. The application of Q-tube pressure reactor in biofuels manufacture is also discussed. Conclusion: The literature survey clearly revealed that Q-tube is a valid tool in organic synthesis.

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The twin drug approach for novel nicotinic acetylcholine receptor ligands

Cited by 16 publications

References 66 publications

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Preparation, functionalization and characterization of engineered carbon nanodots

The Q-tube System, A Nonconventional Technology for Green Chemistry Practitioners

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