The Turnover of Lipids

Burton, Robert M.

doi:10.1007/978-1-4615-7166-7_5

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Whereas after five days phospholipid label is lost from rat visual system structures with an apparent half-life of about 12 days (Toews and Morell, 19791, cholesterol label continues to increase for at least 35 days. This is probably due to the greater metabolic stability of brain cholesterol relative to phospholipids (Burton, 1971). The greater stability of cholesterol is true of TRANSPORT OF CHOLESTEROL 249 almost all body components because the only quantitatively significant route for cholesterol to leave the body is by equilibration with the entero-hepatic shunt;…”

Section: Discussionmentioning

confidence: 99%

Cholesterol is a component of the rapid phase of axonal transport

1980

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Twenty-two-day-old rats were injected intraocularly with [3H]acetate and killed between 1 hr and 35 days later. Cholesterol was isolated from the retinas, optic tracts, lateral geniculate bodies, and superior colliculi. Within the retina, radioactivity was rapidly incorporated into cholesterol with maximal labeling present one hour after injection. Transported labeled cholesterol (contralaterally corrected for systemic background labeling) was present in the superior colliculus by three hours. Radioactive cholesterol accumulated in all visual structures throughout the 35-day period, but the rate of accumulation was maximal at about the time of arrival of the initial pulse of radioactivity. Colchicine treatment of the retina blocked transport of cholesterol but not its synthesis by the retina. The results indicate that cholesterol is rapidly transported in the visual system and also released from the retina for a prolonged period after its synthesis.

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Section: Discussionmentioning

confidence: 99%

Cholesterol is a component of the rapid phase of axonal transport

1980

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“…The composition of brain lipids (e.g., phospholipids, sphingolipids, gangliosides, etc. ,) has been shown to differ with age in both human (Yasuf and Dickerson, 1977) and rat brain (Burton, 1971; Thomas and Kirksey, 1976). In the guinea pig, however, there is little reported information about the variation in fatty acid composition of the brain as a function of age.…”

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confidence: 99%

Comparison of the Development of the Fatty Acid Content and Composition of the Brain of a Precocial Species (Guinea Pig) and a Non‐Precocial Species (Rat)

Patel

Clark

1980

Journal of Neurochemistry

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The fatty acid compositions of the brains of a precocial (guinea pig) and a non-precocial (rat) species have been studied as a function of development. In the rat brain the total fatty acid content expressed as mg g wet wt.-1 increased more than fourfold during the period from 5 days after birth to adulthood. However, the percentage composition of this total fatty acid content when expressed per individual fatty acid remained fairly constant, with the exception of nervonic acid (C24:1) which also increased fourfold on a percentage basis. In the guinea pig brain, however, at birth the total fatty acid content, expressed as mg g wet wt-1, is the same as that of the adult, the concentration doubling during the period from 25 days before birth until birth. Again, if the fatty acid content is analysed and expressed on a percentage basis, the relative concentrations of the individual fatty acids remain fairly constant over the period from 25 days before birth until adulthood, with the exception of nervonic (C24:1) acid which increases about fivefold from 25 days before birth to birth and only marginally (20%) from birth to adulthood. These results are discussed in relationship to the onset of neurological competence in the two species. It is concluded that the increase in fatty acid content (both total and individually) of the brains of these species as a function of the foetal and neonatal development follows a pattern which is similar to the pattern of development of certain key enzymes of energy metabolism and of neurological competence.

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The Turnover of Lipids

Cited by 2 publications

References 21 publications

Cholesterol is a component of the rapid phase of axonal transport

Cholesterol is a component of the rapid phase of axonal transport

Comparison of the Development of the Fatty Acid Content and Composition of the Brain of a Precocial Species (Guinea Pig) and a Non‐Precocial Species (Rat)

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