The Turkish experience with therapeutic plasma exchange: A national survey

Korkmaz, Serdal; Medeni, Şerife Solmaz; Demırkan, Fatih; Beşışık, Sevgi Kalayoğlu; Dadin, Senem Altay; Çağlıyan, Gülsüm Akgün; Hacioglu, Sibel; Sarı, İsmail; Şahin, Deniz; Arat, Mutlu; Dağdaş, Simten; Özet, Gülsüm; Kutlu, Nermin; Akyol, Tülay Karaağaç; Özcebe, Osman; Teke, Hava Üsküdar; Ünal, Demet; Guner, Naile; Tombak, Anıl; Çelik, Halil; Bay, Ilker; Kıkı, İlhami; Ozgur, Gokhan; Erkurt, Mehmet Ali; Özatlı, Düzgün; Meletli, Özgür; Demi̇rci̇oğlu, Si̇nan; Demir, Cengiz; Kurtoğlu, Erdal; Vural, Fılız; Töbü, Mahmut; Karakuş, Abdullah; Ayyıldız, Orhan; Dal, Mehmet Sinan; Öztürk, Berna Afacan; Albayrak, Murat; Ocakci, Serkan; Bolaman, Zahit; Sönmez, Mehmet; Karakuş, Volkan; Sevindik, Omur Gokmen; Berber, İlhami; Doğu, Mehmet Hilmi; Gültürk, Emine; Ulaş, Turgay; Payzın, Bahriye; Kuku, İrfan; Cagirgan, Seckin; Altuntaş, Fevzi

doi:10.1016/j.transci.2019.04.015

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…Neurological diseases constituted 36.7%, hematological diseases 31.04%, renal diseases 25.8%, and rheumatological diseases 6.46% of the reported TPE indications. 10 Excluding a study involving the geriatric patient population, it is generally observed in reported TPE indications from Turkiye that neurological or hematological diseases take precedence. However, this study highlights that liver diseases (such as liver failure and rejection after liver transplantation) constitute the most frequent TPE indication.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of indications for therapeutic plasmapheresis procedures applied in our center

Eryıldız Yücel,

Kuku,

Kaya

et al. 2024

JCHOR

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Aims: Therapeutic plasma exchange (TPE) is a process in which pathological substances (autoantibodies, alloantibodies, immune complexes, lipoproteins, cryoglobulins, etc.) in the patient's plasma are removed from the body along with the patient's plasma and replaced with replacement fluid (allogeneic donor plasma, colloid, crystalloid). It is applied as a complementary treatment method in many diseases that can cause high morbidity and mortality, either in the primary treatment of the disease (main treatment) or as an adjunctive treatment in the main treatment of the disease. Today, TPE is increasingly used in various clinics (toxicology, endocrinology, etc.) for different diseases/causes, especially in hematological, neurological, and nephrological diseases. Methods: Adult patients who underwent therapeutic plasma exchange in our therapeutic apheresis center between May 2017 and May 2019 were included in the study, and the data were obtained by retrospectively reviewing patient records in the therapeutic apheresis center and our hospital's automation system. Results: In the two-year period, a total of 1957 TPE procedures were performed on 441 patients. It was determined that 255 of the patients undergoing TPE procedures (57.8%) had indications related to liver diseases (acute liver failure, acute exacerbation of chronic liver failure, and rejection after liver transplantation), while 186 (42.2%) had indications related to non-liver diseases. Among the 186 patients undergoing TPE for non-liver diseases, it was found that 69 (37.1%) were for hematological, 38 (20.4%) for neurological, 32 (17.2%) for renal, and 47 (25.3%) for other diseases. Conclusion: Due to the large number of liver transplants performed in our Liver Transplant Institute, the majority of TPE indications at our hospital are related to liver diseases. However, the evaluation of TPE indications excluding liver diseases revealed that the indications and frequencies of patients undergoing TPE were consistent with the overall results reported in studies from both our country and abroad.

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Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of indications for therapeutic plasmapheresis procedures applied in our center

Eryıldız Yücel,

Kuku,

Kaya

et al. 2024

JCHOR

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“…We most frequently applied TPE Procedure in patients with Myasthenia-Gravis syndrome (34.7%). Recently Korkmaz et al reported that MG is the most frequent neurological indication for TPE in The Turkish national survey [14]. According to the ASFA guidelines, TPE is the front-line therapy (category I, grade 1A) for acute inflammatory demyelinating polyneuropathy disease (Guillain-Barré syndrome), moderate-severe myasthenia Gravis disease, including myasthenic crisis, unstable or refractory disease, unstable disease activitythymectomy.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic plasma exchange in neurological diseases: Eleven years experience at a tertiary care center in Turkey

et al. 2021

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Therapeutic plasma exchange (TPE) is an apheresis procedure in which plasma is separated from the blood cellular components ex vivo, allocated, and replaced with another plasma or a plasma-replacing fluid. This study aimed to define the rate of complications and determine TPE distribution in various neurological diseases. Our study is a retrospective analysis of neurologic diseases requiring TPE between 2008 and 2019 that were selected using the medical records of neurology departments and apheresis units database. We performed 1459 TPE procedures on 207 patients between 2008 and 2019. TPE Procedure is most frequently applied in patients with Myasthenia-Gravis syndrome (34.7%). The complication ratio was 1.6% from a total of 1459 TPE procedures. The most commonly specified adverse event was allergic reactions 11 (5.3%), followed by hypotension 6 (2.9%). TPE was safe and tolerable, with manageable complications in experienced hands. K E Y W O R D Sacute inflammatory demyelinating polyradiculoneuropathy (AIDP), chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis (MS), therapeutic plasma exchange

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“…There are numerous conditions and/or diseases present within non‐transplantation patients for which TPE has proved beneficial 1 . Facilities for TPE may not be readily available in developing countries, and in centers with adequate facilities the procedure is too costly, thus patients cannot afford to pay for such procedures out‐of‐pocket 2‐4 . We report here TPE with standard hemodialysis machine and patient outcomes.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic plasma exchange with standard hemodialysis machine as an alternative to dedicated apheresis device: A 5‐year experience

Pongsittisak

Satpanich

Kurathong

2020

J of Clinical Apheresis

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Patients suffering from various diseases have been shown to benefit from therapeutic plasma exchange (TPE). However, in developing countries, there are many obstacles hindering the establishment and initiation of TPE programs. These include inadequate funding and lack of government healthcare coverage. Our center in Thailand practices a unique membrane plasma separator technique using a hemodialysis machine incorporated with a plasma separator. Over a 5 year period, there were 130 such sessions conducted in 24 patients. The indications for TPE treatment included neurological, hematological, and nephrological diseases. Overall, response to TPE was good. Some TPE-related adverse events did occur, but none were life-threatening. Unfortunately, infection remained a problem and was sometimes a cause of death. Future challenges include minimization of infection rates and making TPE treatment readily accessible to patients.

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The Turkish experience with therapeutic plasma exchange: A national survey

Cited by 8 publications

References 28 publications

Retrospective evaluation of indications for therapeutic plasmapheresis procedures applied in our center

Retrospective evaluation of indications for therapeutic plasmapheresis procedures applied in our center

Therapeutic plasma exchange in neurological diseases: Eleven years experience at a tertiary care center in Turkey

Therapeutic plasma exchange with standard hemodialysis machine as an alternative to dedicated apheresis device: A 5‐year experience

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