The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells

Corselli, Mirko; Chen, Chien-Wen; Sun, Bin; Yap, Solomon; Rubin, J. Peter; Péault, Bruno

doi:10.1089/scd.2011.0200

Cited by 345 publications

(456 citation statements)

References 42 publications

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“…The term “perivascular cells” commonly includes classically defined pericytes surrounding the microvasculature, as well as other nonpericyte cells within the perivascular niche of the macrovasculature which have also been shown to display properties of MSCs 53, 54, 55. However, recent evidence would suggest a clear functional distinction between pericytes and MSC progenitors in the perivascular niche 56.…”

Section: Are Wharton's Jelly Mscs Perivascular In Origin?mentioning

confidence: 99%

Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells

Davies

Walker

Keating

2017

Stem Cells Translational Medicine

158

145

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The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under‐appreciated. Key issues are that consensus on the anatomical structures within the cord is lacking, and potentially different populations are identified as arising from a single source. To help address these points, we propose a histologically based nomenclature for cord structures and provide an analysis of their developmental origins and composition. Methods of cell isolation from Wharton's jelly are discussed and the immunophenotypic and clonal characteristics of the cells are evaluated. The perivascular origin of the cells is also addressed. Finally, clinical trials with umbilical cord cells are briefly reviewed. Interpreting the outcomes of the many clinical studies that have been undertaken with mesenchymal stromal cells from different tissue sources has been challenging, for many reasons. It is, therefore, particularly important that as umbilical cord cells are increasingly deployed therapeutically, we strive to better understand the derivation and functional characteristics of the cells from this important tissue source. Stem Cells Translational Medicine 2017;6:1620–1630

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Section: Are Wharton's Jelly Mscs Perivascular In Origin?mentioning

confidence: 99%

Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells

Davies

Walker

Keating

2017

Stem Cells Translational Medicine

158

145

View full text Add to dashboard Cite

show abstract

“…MSCs are increasingly believed to reside in the vasculature [2,[20][21][22][23]; therefore, tissues rich in blood vessels, particularly microvessels (capillaries), are ideal for the isolation of MSCs in large quantities for clinical applications. The adipose tissue is endowed with an extensive capillary network [24] and is one of the rare tissues that can be partially removed from a living person without causing harm.…”

Section: Adsc As An Ideal Msc For Therapymentioning

confidence: 99%

Allogeneic and Xenogeneic Transplantation of Adipose-Derived Stem Cells in Immunocompetent Recipients Without Immunosuppressants

Lin

Lue

2012

Stem Cells and Development

185

152

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“…Pericytes and ACs have also been isolated from several other human tissues such as fat and lung. (41,(196)(197)(198) MECs, pericytes, and ACs all have common mesodermal multipotency and display typical MSC markers, suggesting their contributions to the heterogeneous MSCs entity. (197) Pericytes are commonly regarded as a structural component of small blood vessels that regulate vascular contractility, stability, and integrity.…”

Section: Mscs Manage Vascular Homeostasismentioning

confidence: 99%

Mesenchymal Stem Cells Manage Endogenous Tissue Regeneration

2016

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BACKGROUND: Current findings set a new understanding that every adult tissue has its own intrinsic progenitor or stem cell, give a potency for their innate turnover dynamics. This broke the old assumption that adult tissues cannot regenerate themselves. Localized tissue regeneration was regulatory oversight by a separate class of local cells originating as perivascular cells, suggested a profound influence on using specific cells for cell therapies as a health care delivery tool set.CONTENT: The mesenchymal stem cell (MSC) could be mobilized from the marrow or other depots or can be culture-expanded MSCs which are delivered to the damage site either by direct or systemic injection. MSCs act paracrine and autocrine by inducing a variety of cytokines and growth factors which suppress local immune system, inhibit fibrosis (scar formation) and apoptosis, enhanceangiogenesis, and stimulate mitosis and differentiation of tissue, intrinsic reparative or stem cells. These referred a trophic effects, different from the direct differentiation of MSCs into repair tissue. Thus, MSC suggested as a multidrug delivery vehicles in response of injury. In this regard, the trophic effects of MSCs may have profound clinical use.SUMMARY: Managing the body’s natural repair and regeneration capacities is the new frontier for modern medicine and the basis for the science of cell therapies. Study of MSCs become one avenue that being pursued to explore the endogenous tissue regeneration management, so that people have a great expectation to solve many severe diseases.KEYWORDS: mesenchymal stromal/stem cell, paracrine or autocrine activities, trophic mediator, inflammation, wound healing

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The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells

Cited by 345 publications

References 42 publications

Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells

Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells

Allogeneic and Xenogeneic Transplantation of Adipose-Derived Stem Cells in Immunocompetent Recipients Without Immunosuppressants

Mesenchymal Stem Cells Manage Endogenous Tissue Regeneration

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