The tumour and its microenvironment – a complicated interplay

Białas, Magdalena; Dyduch, Grzegorz; Adamek, Dariusz

doi:10.5114/wo.2011.25659

Cited by 2 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, it should also be mentioned that during vascular network formation a very significant role is played by interactions between the tumour and the surrounding stromal cells, which creates a unique tumour microenvironment. Moreover, both tumour and stromal cells release a wide array of angiogenic factors that influence endothelial cell recruitment and thus affect the process of angiogenesis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The role of tumour microenvironment in gastric cancer angiogenesis

Brzozowa

Michalski

Harabin-Słowińska

et al. 2014

View full text Add to dashboard Cite

Gastric cancer is one of the most common cancers in the world. More than 95% of gastric cancers are adenocarcinomas originating from the glandular epithelium of the stomach lining. Unfortunately, a large number of patients are diagnosed when the tumour is at unresectable stage. Therefore, it is very important to understand the mechanisms involved in gastric cancer pathogenesis. One of them is angiogenesis, which means the formation of new blood vessels from pre-existing vasculature. This process is dependent on interactions between the tumour and surrounding stromal cells which create the tumour microenvironment. Moreover, both tumour and stromal cells release a wide array of angiogenic factors that have an influence on endothelial cell recruitment and thus affect the process of angiogenesis. In this paper we discuss the role of tumour microenvironment in gastric cancer angiogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of tumour microenvironment in gastric cancer angiogenesis

Brzozowa

Michalski

Harabin-Słowińska

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Therefore, targeting tumors with angiogenesis-based therapy remains a very significant area of preclinical and clinical studies [ 3 , 4 ]. The main strategies for such therapy have been developed to prevent stimulation of endothelial cells by a rich variety of pro angiogenic molecules released from the extracellular matrix by proteases or secreted both by tumor and stromal cells [ 2 , 5 ]. Of all the pro angiogenic molecules, the most significant and well described is vascular endothelial growth factor (VEGF), which is produced at high levels by tumor cells and stromal cells [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Reviews The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?

Brzozowa¹,

Wojnicz²,

Kowalczyk-Ziomek³

et al. 2013

View full text Add to dashboard Cite

Angiogenesis is a complex multistep process by which new capillary structures arise from pre-existing vessels in response to angiogenic stimuli. This process plays a key role during tumorigenesis because the vascular network within the tumor enables malignant cells to establish distant metastases. Thus, it is not surprising that targeting tumors with angiogenesis-based therapy remains a significant area of preclinical and clinical studies. One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4). Emerging evidence suggests that blockade of DLL4 in tumors results in excessive but non-productive angiogenesis which affects tumor growth, even in tumors which are insensitive to anti-VEGF therapy. Nevertheless, the careful evaluation of adverse effects on normal organs’ physiology in relation to therapeutic doses of DLL4 inhibitors will be critical for advancement of DLL4 blocking agents in clinical practice.

show abstract

The tumour and its microenvironment – a complicated interplay

Cited by 2 publications

References 17 publications

The role of tumour microenvironment in gastric cancer angiogenesis

The role of tumour microenvironment in gastric cancer angiogenesis

Reviews The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?

Contact Info

Product

Resources

About