The Tumor Suppressor p53 in the Center of a Strategy Aiming at the Alleviation of Side Effects in Cancer Therapies

Wiesmüller, Lisa

doi:10.1002/(sici)1521-3773(20000515)39:10<1768::aid-anie1768>3.0.co;2-a

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…17 in human and most mammals; it encodes for a 53 kDa phosphoprotein which has the ability of binding to DNA and acting as a transcription factor. In response to chemical damage, p53 is activated to direct stress-specific transcriptional response programs such as slowing down cell division or induce programmed cell death [6, 7] which makes it a primary target for inactivation in cancer [8]. Therefore, p53 is one of the most frequently mutated genes in human cancers with the most mutations detected are Single-Nucleotide Polymorphisms (SNPs) [9].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats

Aly

Fetaih

Hassanin

et al. 2019

Analytical Cellular Pathology

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Natural oils are traditional medicinal herbs, which have attracted interests for its potential anti-inflammatory and anticancer activities. The present work is aimed at evaluating the protective effect of garlic oil and cinnamon oil on diethylnitrosamine- (DENA-) and 2-acetylaminofluorene- (2-AAF-) induced p53 gene mutation and hepatocarcinogenesis in rats. Forty male albino rats were divided into 4 equal groups: control, hepatocellular carcinoma (HCC), garlic oil-HCC, and cinnamon oil-HCC. The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. In addition, the glutathione (GSH) level and superoxide dismutase (SOD) activities were increased. While HCC rats pretreated with garlic oil or cinnamon oil were significantly reversed, these destructive actions increased GSH and SOD levels. The HCC-induced group showed histopathological features of liver cancer including hypercellularity, nuclear hyperchromasia, mitotic figures, and preneoplastic foci. On the other hand, HCC rats pretreated with garlic oil or cinnamon oil revealed partial reversal of normal liver architecture. The present findings proposed that these natural oils have the ability to improve liver function, significantly reduced the liver toxicity and HCC development. However, further sophisticated studies are recommended before their use as conventional therapeutics for HCC treatment.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats

Aly

Fetaih

Hassanin

et al. 2019

Analytical Cellular Pathology

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“…Studies on cancer formation of heterozygote over null mive have provided clear evidence of haploinsuffiency at the Trp53 locus [89], and this haploinsuffiency is reflected by a partial loss of HR control functions in mouse embryo fibroblasts from Trp53+/-mice, when using the fluorescence-based test [126]. For the development of p53-based therapeutic strategies scientists have tested the applicability of synthetic peptides and small molecule compounds to enhance or to reconstitute p53-dependent activities in transcription, cell cycle control, and apoptosis induction [127]. Recently, progress has been made in targeting breast cancer by a novel therapeutic approach that selectively kills DSB repair defective cells [128].…”

Section: Conclusion: Dsb Repair Activities As a Potential Marker Of mentioning

confidence: 99%

Double Strand Break Repair Activities of p53 as Potential Tumor Suppressor Function Counteracting Mammary Tumor Development

Wiesmüller¹

2006

CWHR

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Correct repair of DNA double strand breaks (DSBs) is central to the maintenance of the genome integrity, since errors give rise to translocations, deletions, duplications, and expansions, thereby accelerating the multistep process of tumorigenesis. Altered DSB repair activities have been closely linked to the development of both inherited and sporadic breast carcinomas, as indicated by frequent mutations or abnormal expression of DSB repair-related genes. Mammary epithelium appears particularly dependent on proper p53 function as indicated by the high frequency of TP53 mutations in sporadic breast cancers and the high incidence of breast cancer among Li-Fraumeni syndrome patients with mutated p53. Convergent studies demonstrated that p53 regulates recombinative DSB repair independently of classic tumor suppressor functions in transactivating target genes that are implicated in growth control or apoptosis. Moreover, physical and genetic links were established between p53 and recombination factors, such as Rad51, BRCA1 and BRCA2. Mechanistically, p53 restrains DNA exchange events involving imperfectly homologous sequences, thereby suppressing error-prone genome rearrangements. p53 as a DNA repair factor may, therefore, significantly contribute to the suppression of mammary tumor development, which is supported by the observation that the functional status of p53 as a tumor suppressor closely parallels its regulatory activities in recombination.

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ChemInform Abstract: The Tumor Suppressor p53 in the Center of a Strategy Aiming at the Alleviation of Side Effects in Cancer Therapies

Wiesmüeller

2000

ChemInform

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The Tumor Suppressor p53 in the Center of a Strategy Aiming at the Alleviation of Side Effects in Cancer Therapies

Cited by 5 publications

References 19 publications

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats

Double Strand Break Repair Activities of p53 as Potential Tumor Suppressor Function Counteracting Mammary Tumor Development

ChemInform Abstract: The Tumor Suppressor p53 in the Center of a Strategy Aiming at the Alleviation of Side Effects in Cancer Therapies

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