The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Tristán-Ramos, Pablo; Rubio-Roldán, Alejandro; Peris, Guillermo Sanahuja; Sánchez, Laura; Amador-Cubero, Suyapa; Viollet, Sébastien; Cristofari, Gaël; Heras, Sara R.

doi:10.1038/s41467-020-19430-4

Cited by 42 publications

(28 citation statements)

References 91 publications

(167 reference statements)

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“…Perhaps most critically, restoration of let-7 has been shown to have strong anticancer properties. This has led to it being classified as a tumor suppressor [52], as well as a promising target for future cancer therapies [53].…”

Section: Let-7's Role In Cancer and Angiogenesismentioning

confidence: 99%

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

2021

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The let-7 family is among the first microRNAs found. Recent investigations have indicated that it is highly expressed in many systems, including cerebral and cardiovascular systems. Numerous studies have implicated the aberrant expression of let-7 members in cardiovascular diseases, such as stroke, myocardial infarction (MI), cardiac fibrosis, and atherosclerosis as well as in the inflammation related to these diseases. Furthermore, the let-7 microRNAs are involved in development and differentiation of embryonic stem cells in the cardiovascular system. Numerous genes have been identified as target genes of let-7, as well as a number of the let-7’ regulators. Further studies are necessary to identify the gene targets and signaling pathways of let-7 in cardiovascular diseases and inflammatory processes. The bulk of the let-7’ regulatory proteins are well studied in development, proliferation, differentiation, and cancer, but their roles in inflammation, cardiovascular diseases, and/or stroke are not well understood. Further knowledge on the regulation of let-7 is crucial for therapeutic advances. This review focuses on research progress regarding the roles of let-7 and their regulation in cerebral and cardiovascular diseases and associated inflammation.

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Section: Let-7's Role In Cancer and Angiogenesismentioning

confidence: 99%

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

2021

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“…The Let-7 member miR-98 inhibited the malignant phenotypes of NSCLC cells through directly targeting ITGB3 and PAK [ 16 ]. Downregulation of Let-7 correlates with accumulation of insertions of the transposable element L-1 in human lung cancer, likely causing genome instability and driving tumor genome evolution [ 32 ]. Let-7 can bind directly to L1-mRNA.…”

Section: Resultsmentioning

confidence: 99%

SALL4 and microRNA: The Role of Let-7

Sauer

Hussein

et al. 2021

Genes

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SALL4 is a zinc finger transcription factor that belongs to the spalt-like (SALL) gene fam-ily. It plays important roles in the maintenance of self-renewal and pluripotency of embryonic stem cells, and its expression is repressed in most adult organs. SALL4 re-expression has been observed in different types of human cancers, and dysregulation of SALL4 contributes to the pathogenesis, metastasis, and even drug resistance of multiple cancer types. Surprisingly, little is known regard-ing how SALL4 expression is controlled, but recently microRNAs (miRNAs) have emerged as im-portant regulators of SALL4. Due to the ability of regulating targets differentially in specific tissues, and recent advances in systemic and organ specific miRNA delivery mechanisms, miRNAs have emerged as promising therapeutic targets for cancer treatment. In this review, we summarize cur-rent knowledge of the interaction between SALL4 and miRNAs in mammalian development and cancer, paying particular attention to the emerging roles of the Let-7/Lin28 axis. In addition, we discuss the therapeutic prospects of targeting SALL4 using miRNA-based strategies, with a focus on the Let-7/LIN28 axis.

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“… 14 The human genome contains 13 let-7 family members, which encode 9 mature miRNAs, due to sequence similarity, it is generally considered that the functions of all members overlap. 33 The let-7 family plays a complex regulatory function in many diseases. In addition to being a diagnostic marker for cancer, it is more likely to be a screening factor or a prognostic evaluation indicator.…”

Section: Discussionmentioning

confidence: 99%

The Potential Diagnostic Accuracy of Let-7 Family for Cancer: A Meta-Analysis

Zhang

Gao

2021

Technol Cancer Res Treat

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Background: Cancer is a global public health problem affecting human health. Early stage of cancer diagnosis, when it is not too large and has not spread is important for successful treatment. Many researchers have proposed that the let-7 microRNA family can be used as a biomarker for cancer diagnosis. The aim of this meta-analysis is to evaluate whether let-7 family can be used as a diagnostic tool for cancer patients. Methods: We conducted a comprehensive literature search on PubMed, EMBASE, Web of Science, Cochrane Library, Google Scholar, China National Knowledge Infrastructure (CNKI) and Wanfang database, updated to October 23, 2020. A random effects model was used to pool the sensitivity and specificity. Besides, we measured the diagnostic value using positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the curve (AUC) were pooled. In addition, meta-regression and subgroup analysis were performed to explore the possible sources of heterogeneity, and Deeks’ funnel chart was used to assess whether there was publication bias. Results: 31 studies from 15 articles were included in the current meta-analysis. The overall sensitivity, specificity, PLR, NLR, DOR and AUC were 0.80 (95% CI: 0.75-0.85), 0.81 (95% CI: 0.74-0.86), 4.2 (95% CI: 2.9-5.9), 0.24 (95% CI: 0.19-0.32), 17 (95% CI: 10-29) and 0.87 (95% CI: 0.84-0.90), respectively. Subgroup analysis shows that the let-7 family cluster of serum type showed a better diagnostic accuracy of cancer, especially the breast cancer. Although there is no publication bias, it still has some limitations. Conclusions: let-7 family can be considered as a promising non-invasive diagnostic biomarker for cancer.

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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Cited by 42 publications

References 91 publications

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

SALL4 and microRNA: The Role of Let-7

The Potential Diagnostic Accuracy of Let-7 Family for Cancer: A Meta-Analysis

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