The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors

Palano, Maria Teresa; Gallazzi, Matteo; Cucchiara, Martina; Dehò, Federico; Capogrosso, Paolo; Bruno, Antonino; Mortara, Lorenzo

doi:10.37349/etat.2022.00108

Cited by 6 publications

(9 citation statements)

References 190 publications

(265 reference statements)

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“…Immunoscore (IS) is derived from the combined in ltration of CD3 + and CD8 + T cells in both tumor inferior (TI) and tumor stroma (TS)(15). It has been established as a crucial prognostic factor in various tumor types (17)(18)(19), particularly in in ammation-induced tumors like colorectal carcinoma (CRC) and laryngeal squamous cell carcinoma (LSCC). CD8 + T cells, also known as cytotoxic T cells (CTLs), play a vital role in anti-tumor immunity.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Cytotoxic-T-Lymphocytes to Immunosuppressive Cells Ratio (CIL) in Laryngeal Squamous Cell Carcinoma

Zhang,

Heng,

Jin

et al. 2024

Preprint

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Immunoscore (IS), based on CD3/CD8, has been proposed to characterize the immune landscape of the tumor immune microenvironment and has demonstrated an association with the prognosis of LSCC (Laryngeal Squamous Cell Carcinoma). However, traditional IS does not include immunosuppressive cells. The purpose of this study is to evaluate the prognostic performance of cytotoxic-T-lymphocytes to immunosuppressive cells ratio (CIL) in Laryngeal Squamous Cell Carcinoma (LSCC) patients. Two cohorts were included in this study: the training cohort (N = 75) consisted of tumor tissue microarrays from LSCC patients in our department, and the Validation cohort (N = 116) utilized bulk RNA-seq data from the TCGA database. Patients with high IS or CIL showed significantly prolonged overall survival (OS) and disease-free survival (DFS) in both cohorts. Upon analyzing the relative contribution of each parameter, it was found that CIL exhibited the highest significance among the factors examined. It emerged as the strongest predictor of overall survival, emphasizing its crucial influence in determining the outcomes. The prognostic ability of IS-TCGA was similar to the original IS. Additionally, high CILM2-TCGA was associated with prolonged survival of patients with LSCC in the TCGA dataset. CIL, which is easier to construct than IS, proves to be reliable in predicting survival outcomes for patients with LSCC.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Cytotoxic-T-Lymphocytes to Immunosuppressive Cells Ratio (CIL) in Laryngeal Squamous Cell Carcinoma

Zhang,

Heng,

Jin

et al. 2024

Preprint

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“…The prostate TME contains carcinoma-associated fibroblasts (CAFs) and several types of immune cells, including but not limited to, T cells, B cells, NK cells, macrophages, myeloidderived suppressor cells (MDSCs), and neutrophils (Kwon et al, 2021;Palano et al, 2022) (Figure 7). These cell types all display plasticity and can differentiate into multiple subtypes with different effects on tumor growth and therapy resistance.…”

Section: The Crosstalk Between Swi/snf Complexes and The Tumor Microe...mentioning

confidence: 99%

SWI/SNF chromatin remodelers in prostate cancer progression

Ordonez-Rubiano,

Strohmier,

Sood

et al. 2024

Front. Epigenet. Epigenom.

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Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer-related deaths in men in the US. The majority of PCa cases arise in the luminal cells of the prostate and develop into adenocarcinoma. Primary PCas are heterogeneous and have alterations in a variety of tumor suppressors and oncogenes; however, the vast majority are dependent on gene expression regulation by androgen receptor (AR), making it the focus for most targeted therapy development. As the incidence of PCa cases resistant to AR-targeted therapies rises, there is renewed attention on how additional genetic and epigenetic alterations contribute to PCa progression and resistance. In this review we summarize the efforts made over the past 20 years to dissect the function of the SWI/SNF chromatin remodelers in PCa. We mainly focus on how SWI/SNF complexes regulate different aspects of AR signaling, facilitate other key drivers in PCa, promote the advancement of the disease, and regulate the tumor microenvironment.

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“…PCa is an immune-responsive malignancy, but it remains unclear why it is less responsive to ICI than other tumors [ 141 , 142 ]. The efficacy of ICI may be related to the microbiota composition [ 143 ].…”

Section: Developing Therapeutic Applications Targeting the Microbiomementioning

confidence: 99%

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

Kuštrimović

Bombelli

Baci

et al. 2023

IJMS

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Growing evidence of the microbiome’s role in human health and disease has emerged since the creation of the Human Microbiome Project. Recent studies suggest that alterations in microbiota composition (dysbiosis) may play an essential role in the occurrence, development, and prognosis of prostate cancer (PCa), which remains the second most frequent male malignancy worldwide. Current advances in biological technologies, such as high-throughput sequencing, transcriptomics, and metabolomics, have enabled research on the gut, urinary, and intra-prostate microbiome signature and the correlation with local and systemic inflammation, host immunity response, and PCa progression. Several microbial species and their metabolites facilitate PCa insurgence through genotoxin-mediated mutagenesis or by driving tumor-promoting inflammation and dysfunctional immunosurveillance. However, the impact of the microbiome on PCa development, progression, and response to treatment is complex and needs to be fully understood. This review addresses the current knowledge on the host–microbe interaction and the risk of PCa, providing novel insights into the intraprostatic, gut, and urinary microbiome mechanisms leading to PCa carcinogenesis and treatment response. In this paper, we provide a detailed overview of diet changes, gut microbiome, and emerging therapeutic approaches related to the microbiome and PCa. Further investigation on the prostate-related microbiome and large-scale clinical trials testing the efficacy of microbiota modulation approaches may improve patient outcomes while fulfilling the literature gap of microbial–immune–cancer-cell mechanistic interactions.

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The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors

Cited by 6 publications

References 190 publications

Prognostic Significance of Cytotoxic-T-Lymphocytes to Immunosuppressive Cells Ratio (CIL) in Laryngeal Squamous Cell Carcinoma

Prognostic Significance of Cytotoxic-T-Lymphocytes to Immunosuppressive Cells Ratio (CIL) in Laryngeal Squamous Cell Carcinoma

SWI/SNF chromatin remodelers in prostate cancer progression

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

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