The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer

Trisciuoglio, Daniela; Degrassi, Francesca

doi:10.3390/cancers14010006

Cited by 13 publications

(12 citation statements)

References 152 publications

(198 reference statements)

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“…Role of MT force and its transmission depends on cytoskeleton alteration, which is associated with the tubulin tyrosination level [ 38 ]. TTL specifically accelerates α-tubulin tyrosination to influence the interaction with +TIPs, including Clip170 [ 21 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration

Xie

et al. 2022

Cell Death Dis

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The microtubule (MT) plus-end binding protein Clip170 is associated closely with breast cancer invasion and migration. In this study, Clip170 tension observed by a newly designed cpstFRET tension probe was suggested to be positive related to breast cancer aggressiveness, which could be regulated by α-tubulin detyrosination-induced MT disassembly. Clip170 phosphorylation induced by Ribosomal protein S6 kinase (RSK) could also increase its tension and promote the conversion of a discrete comet-like Clip-170 distribution into a spotty pattern during cancer metastasis. Heightened Clip170 tension was correlated with the formation of cortactin-associated filopodia and lamellipodia, and then promoted invasion and metastasis both in vitro and in vivo. Meanwhile, Clip170 tension enhanced at the leading edge in directional migration, accompanying with IQGAP1 subcellular distribution variation. Our work indicates that the malignancy and directionality during breast cancer migration depend on the magnitude and polarization of Clip170 tension, and we suggest Clip170 tension as a new potential drug target for breast cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration

Xie

et al. 2022

Cell Death Dis

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“…These LC3-II-marked autophagosomes are transported on MT tracts via dyneins, while lysosomes are transported along MTs by kinesin-1. These bidirectional movements of autophagosomes and lysosomes enable their fusion into autolysosomes, leading to the degradation of autophagosomal contents [ 28 ]. As illustrated by the examples above, MTs and MAPs clearly play critical roles in host innate immune responses, but it is unclear if viral MAPs can perform a similar regulation (or deregulation) of these host immune responses.…”

Section: Functions Of the Mt Networkmentioning

confidence: 99%

Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins

Seo

Gammon

2022

Viruses

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Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to sites of replication after entry and to promote egress from the cell. However, mounting evidence suggests that the MT network is also a key regulator of host immune responses to infection. At the same time, viruses have acquired mechanisms to manipulate and/or usurp MT networks to evade these immune responses. Central to most interactions of viruses with the MT network are virally encoded microtubule-associated proteins (MAPs) that bind to MTs directly or indirectly. These MAPs associate with MTs and other viral or cellular MAPs to regulate various aspects of the MT network, including MT dynamics, MT-dependent transport via motor proteins such as kinesins and dyneins, and MT-dependent regulation of innate immune responses. In this review, we examine how viral MAP interactions with the MT network facilitate viral replication and immune evasion.

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“…It has been shown recently that TUBB mRNA expression is upregulated in breast cancer patients resistant to chemotherapy [ 10 , 15 ]. Mutations in TUBB have been shown to demonstrate resistance to chemotherapy [ 16 , 17 ], in which the l240I mutation shows specific resistance to vincristine [ 18 ]. In contrast, A248V, A185T, and R306C mutations confer resistance to paclitaxel [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Identification of TUBB as Potential Prognostic Biomarker for Worse Prognosis in ERα-Positive and Better Prognosis in ERα-Negative Breast Cancer

Alhammad

2022

Diagnostics

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Tubulin β class I gene (TUBB) is highly expressed in various cancers and plays several roles in carcinogenesis. However, the prognostic value of TUBB in breast cancer remains to be investigated. GEPIA and Breast Cancer Gene-Expression Miner were used to explore TUBB expression in breast cancer patients. Kaplan–Meier Plotter was used to assess the relationship between TUBB expression and several prognostic indicators including overall, distant metastasis-free, and relapse-free survival in ERα-positive and ERα-negative breast cancer. The genes that correlate with TUBB in ERα-positive and ERα-negative breast cancer were explored and the pathways were investigated using GSCA. The correlation between TUBB and several gene markers of immune cells was explored using GEPIA. ERα-positive breast cancer patients with increased TUBB showed worse prognosis, possibly through the activation of the TSC/mTOR pathway, whereas ERα-negative breast cancer patients with increased TUBB mRNA showed better prognosis. Significant positive correlations were observed between TUBB and gene markers of immune cells in ERα-positive breast cancer patients, whereas significant negative correlations were observed in ERα-negative breast cancer patients. The analysis revealed that TUBB might be considered as a predictive biomarker for worse prognosis in ERα-positive and better prognosis in ERα-negative breast cancer.

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The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer

Cited by 13 publications

References 152 publications

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration

Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins

Bioinformatics Identification of TUBB as Potential Prognostic Biomarker for Worse Prognosis in ERα-Positive and Better Prognosis in ERα-Negative Breast Cancer

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