The truth about hormone replacement therapy and breast cancer

Priyadarshi, Sewanti; Fernandez, Imelyn M.; Voige, Hayley; Priore, Giuseppe Del

doi:10.1586/17474108.2.1.25

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In any pregnancy, an inherent ethical tension exists between the rights of the mother and those of the unborn child. It is a conflict that has consumed our society, influences our elections, and has yet to be resolved 40–43 . Uterus transplant recipients with an ongoing pregnancy may present a new situation, but it is the same human dilemma faced for generations.…”

Section: Assessment Of Needmentioning

confidence: 99%

Uterus Transplant

Nair¹,

Stega²,

Smith³

et al. 2008

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

Absolute uterine infertility affects millions of women in the United States and more throughout the world. For instance, each year in the United States about 5,000 hysterectomies are performed in women under the age of 24. In total, nearly 9 million women of reproductive age have had a hysterectomy. Based on fecundity rates, thousands of these women may be candidates for uterus transplantation. An ongoing study enrolling some of these potential recipients onto a uterus transplant "waiting list" has revealed that most of these women have Rokitansky syndrome, hysterectomy secondary to endometriosis, cervical cancer, or compelling personal accounts justifying their candidacy. Fertility restoration by uterus transplantation was derived from fertility preservation research, including the development of the radical trachelectomy, oxygenation and perfusion of the in situ uterus, and work with organ donor networks. A decade of modern animal research set the foundation for this human work. Ongoing experiments include stable, long-term large animal allografts for investigating immunosuppression regimens and other transplantation details. Each of the animal models has contributed to the current knowledge base. Recently, nonhuman primates have been used to further investigate the possibility of human uterus transplantation. Nonhuman primate anatomy is analogous to that of humans with notable exceptions. The first human uterus transplant surgery took place in 2000, but it did not result in a pregnancy. However, taken in total, the magnitude of the intervening work from multiple groups throughout the world has made uterus transplantation a topic for discussion. It may also soon be a reality.

show abstract

Section: Assessment Of Needmentioning

confidence: 99%