The trouble with free-water elimination using single-shell diffusion MRI data: A case study in ageing
Marta M. Correia,
Rafael Neto Henriques,
Marc Golub
et al.
Abstract:Free-water elimination (FWE) modelling for Diffusion Tensor Imaging (DTI) can be used to estimate the free-water (FW) volume fraction, as well as FW-compensated DTI parameters. Single-shell (SS) diffusion MRI acquisitions are more common in clinical cohorts due to time constraints, but the FWE-DTI model is a two-compartment model, hence only well-posed for multi-shell (MS) data. A regularised gradient descent (RGD) method is often applied to SS datasets and has been used to study healthy ageing, Alzheimer’s an… Show more
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