The triglyceride/glucose index as an insulin resistance marker in the pediatric population and its relation to eating habits and physical activity

Sánchez-Escudero, Verónica; Lacalle, Concepción García; Vergaz, A. González; Mateo, Laura Remedios; Cabrero, Araceli Marqués

doi:10.1016/j.endien.2020.08.015

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…It is known that obesity is strongly associated with IR in obese children and adolescents (10,20), which was in line with our study. However, the mechanisms of obesity leading to IR are not fully understood to date.…”

Section: Discussionsupporting

confidence: 93%

Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

et al. 2021

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ObjectiveThis study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.MethodsA total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147).ResultsThe univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) (P < 0.05). Multiple linear regression analysis and mediating effect analysis indicated that body mass index (BMI) could directly regulate FINS and HOMA-IR (both P < 0.05). The results from the mediating effect analysis found that UA partially played an indirect role in the link between BMI, FINS and HOMA-IR (both P < 0.05) but had no effect on fasting blood glucose (P > 0.05).ConclusionsSUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.

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Section: Discussionsupporting

confidence: 93%

Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

et al. 2021

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“…Finally, as a meta-analysis of observational studies, we could not exclude the possible influence of unadjusted residual factors on the results, such as the dietary and nutritional condition of the patients. For example, previous studies have suggested that TyG index is related to low muscle mass [42], eating habits and physical activity [43].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-Glucose Index and the Prognosis of Patients with Acute Ischemic Stroke: A Meta-Analysis

Han²,

Jiang³

et al. 2022

Horm Metab Res

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A higher triglyceride-glucose (TyG) index has been related to an increased incidence of stroke in community population. A meta-analysis was performed to evaluate the association between TyG index and prognosis in patients with acute ischemic stroke (IS). Observational studies, which evaluated the influence of TyG index on functional outcome and mortality in patients with acute IS were retrieved by search the PubMed, Embase, Web of Science, Wanfang and China National Knowledge Infrastructure databases from inception to February 20, 2022. Two authors independently collected the data of study characteristics and outcomes. A random-effect model was used to pool the results via incorporating the influence of possible between-study heterogeneity. Eight cohort studies involving 34 076 patients with acute IS contributed to the study. Pooled results showed that a higher TyG index was independently associated with increased risks of all-cause mortality (OR: 1.60, 95% CI: 1.19–2.15, p=0.002; I2=78%) and poor functional outcome (OR: 1.37, 95% CI: 1.11–1.69, p=0.004; I2=71%). Further sensitivity analyses by excluding one cohort study at a time showed consistent results (p all<0.05). Subgroup analyses showed similar results in prospective and retrospective cohort studies, in non-diabetic and diabetic patients, and in studies with follow-up durations within 3 months and of 12 months (p for subgroup analyses all>0.05). In conclusion, higher TyG index is a predictor of all-cause mortality and poor functional outcome in patients with acute IS, and TyG index may be useful for prognostic evaluation in these patients.

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“…Similar findings were also reported by Sánchez-Escudero et al . ( 37 ) Rodríguez-Gutiérrez et al . ( 38 ), and He et al .…”

Section: Discussionmentioning

confidence: 99%

Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study

Gong

Luo

Wang

et al. 2021

Endocrine Connections

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BACKGROUND: Clinical data on the relationship between TG/HDL ratio and IR suggests that TG/HDL ratio may be a risk factor for insulin resistance. However, there is evidence that different races have different risk of developing insulin resistance. The relationship on TG/HDL ratio and insulin resistance in various populations needs to be improved. Therefore, we investigated whether TG/HDL ratio was linked to insulin resistance in different groups in the United States after controlling for other covariates. METHODS: The current research was conducted in a cross-sectional manner. From 2009 to 2018, NHANES had a total of 49,696 participants, all of whom were Americans. The target-independent variable was TG/HDL ratio measured at baseline, and the dependent variable was insulin resistance. Additionally, the BMI, waist circumference, education, race, smoking, alcohol use, ALT, AST, and other covariates were also included in this analysis. RESULTS: The average age of the 10,132 participants was 48.6±18.4 years, and approximately 4936 (48.7%) were male. After correcting for confounders, fully-adjusted logistic regression revealed that TG/HDL ratio was correlated with insulin resistance (OR=1.51, 95%CI 1.42-1.59). A non-linear interaction between TG/HDL ratio and IR was discovered, with a point of 1.06. The impact sizes and confidence intervals on the left and right sides of the inflection point were 6.28 (4.66-8.45) and 1.69 (1.45-1.97), respectively. According to subgroup analysis, the correlation was strong in female, alcohol use, and diabetes patients. Meanwhile, the inverse pattern was observed in the aged, obese, high-income, and smoking populations. CONCLUSION: In the American population, the TG/HDL ratio is positively associated with IR in a non-linear interaction pattern.

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The triglyceride/glucose index as an insulin resistance marker in the pediatric population and its relation to eating habits and physical activity

Cited by 8 publications

References 23 publications

Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents

Triglyceride-Glucose Index and the Prognosis of Patients with Acute Ischemic Stroke: A Meta-Analysis

Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study

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