The trigger for PSE condition in stress‐susceptible pigs

Cheah, K.S.; Cheah, A.M.

doi:10.1002/jsfa.2740271209

Cited by 62 publications

(19 citation statements)

References 31 publications

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“…This rapidly raises body heat and lactate and lactic acid levels producing local and generalised acidosis. PSS is influenced by heritable factors (23,36,52,90).…”

Section: Main Pathological Characteristics Of Spontaneous Primary Myomentioning

confidence: 99%

Spontaneous primary myopathies in domestic mammals: A review

1987

Veterinary Quarterly

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SUMMARY By reviewing the literature concerning primary myopathies in man and animals, a classification of spontaneous primary myopathies in domestic mammals is made. This classification is based on aetiological factors. Primary myopathies are divided into metabolic, immunologic, toxic, nutritional, congenital, inherited, and inflammatory myopathies. Muscular dystrophies, in accordance with the definition in human cases, are considered as a separate entity. In the description of the different muscle disorders the emphasis is on the structural changes and the pathogenesis. Clinical signs and diagnostic criteria are considered only briefly.

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“…This rapidly raises body heat and lactate and lactic acid levels producing local and generalised acidosis. PSS is influenced by heritable factors (23,36,52,90).…”

Section: Main Pathological Characteristics Of Spontaneous Primary Myomentioning

confidence: 99%

Spontaneous primary myopathies in domestic mammals: A review

1987

Veterinary Quarterly

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confidence: 99%

“…An abnormal increase in rate of calcium efflux from mitochondria isolated from MH pig muscle has been reported (30,31). These studies were performed on muscle obtained from pigs postmortem, after conventional slaughter techniques (30). The stress conditions of slaughter are known to trigger metabolic responses in the muscle similar to those observed in anesthetic-induced MH (32).…”

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confidence: 99%

Abnormality in calcium release from skeletal sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia.

Nelson¹

1983

J. Clin. Invest.

137

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A B S T R A C T Two fractions of sarcoplasmic reticulum, one light (LSR) and one heavy (HSR), were isolated from gracilis muscle of control and malignant hyperthermia (MH)-susceptible pigs. Part of the gracilis muscle biopsy was used to compare the contracture sensitivity of the muscle to the calcium-releasing effects of caffeine on isolated SR membranes. Gracilis muscle of MH pigs was more sensitive to the contracture-producing effects of caffeine than control pig muscle. The caffeine dose-cumulative contracture response curve for MH muscle was shifted left of that for controls.The amount of caffeine-induced calcium released from SR is a function of the amount of calcium preload and this did not differ between LSR of MH and control muscle. When LSR fractions were optimally loaded with calcium for caffeine-induced calcium release, no difference in calcium-releasing effects of varying caffeine doses was observed between MH and control LSR. At calcium preloads below optimal, the MH-LSR appeared to be more sensitive to caffeine-induced calcium release. The HSR fractions could not be loaded with calcium in a manner similar to the LSR fractions because of an apparent calcium-induced calcium release phenomenon. Therefore, calcium threshold for calcium-induced calcium release was compared between MH and control HSR fraction. The effect of caffeine on the calcium-induced calcium release was also studied. The average calcium concentration threshold for calcium-induced calcium release was markedly lower for MH vs. control HSR; 20 vs. 63 nmol Ca2+/mg, respectively. Caffeine decreased the threshold for calcium-induced calcium release more in the MH than in control HSR. Under all conditions studied, the amount of calcium released did not differ INTRODUCTIONMalignant hyperthermia (MH)' is a life threatening hypermetabolic syndrome occurring in genetically predisposed man and swine (1-3). In man, MH is usually associated with the administration of certain anesthetic agents (4, 5); whereas in swine the MH syndrome can also be triggered by stress alone (6, 7). The primary defect associated with MH susceptibility in man and pigs appears to be located in skeletal muscle (8-10). Abnormal metabolic (8,11,12) and contracture (13,14) responses of skeletal muscle from MH-susceptible man and swine have produced a working hypothesis that abnormal increases in myoplasmic calcium ion concentration stimulate the hypermetabolism and skeletal muscle rigidity observed with the MH syndrome.Additional support for a primary lesion in skeletal muscle of MH-affected man and pigs is the fact that dantrolene, a unique skeletal muscle relaxant is an effective prophylactic and therapeutic agent for MH in man (15) Immedi-ately after biopsy, the muscle was placed on ice and minced with scissors into small pieces and placed in 35-ml centrifuge tubes containing 1.4 ml of 20 mM histidine (pH 6.8) per g of muscle. The muscle was homogenized 15 s X 2, setting of 5, using a Polytron homogenizer with a PT 20 generator (Brinkmann Instruments, Inc., Westbury, ...

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“…The selection of a suitable wavelength pair is critical, particularly in the case of experiments which involve aerobic-anaerobic transitions, because of the large change in the redox poise of the c-type cytochromes which accompanies this transition. Moreover, in these skeletal muscle mitochondria, the cytochrome c concentration is high (-0.5 gmol/g protein) [21] when compared with the rat liver mitochondrial level of -0.2 @mol/g protein [ 171, and this increases the experimental difficulty which is encountered.…”

Section: Discussionmentioning

confidence: 99%