The trigeminal pathways

Terrier, Louis-Marie; Hadjikhani, Nouchine; Destrieux, Christophe

doi:10.1007/s00415-022-11002-4

Cited by 23 publications

(11 citation statements)

References 179 publications

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“…Together with the ophthalmic, maxillary and mandibular branches (V1-3), the trigeminal nerve is the largest cranial nerve (V1: 26.000 fibers; V2: 50.000 fibers; V3: 78.000 fibers), responsible for tactile and pain perception of the face and the meninges as well as for motor control of masticatory muscles (37)(38)(39).…”

Section: The Trigeminal Nervementioning

confidence: 99%

“…The ophthalmic division (V1) innervates the upper part of the face, most of the dura mater and cerebral vasculature (see Figure 1 ) ( 37 , 39 , 41 ). It terminates in the lacrimal, frontal and nasociliary nerve which again give rise to small sensory terminal afferents.…”

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

“…It terminates in the lacrimal, frontal and nasociliary nerve which again give rise to small sensory terminal afferents. Due to the major innervation of intracranial structures by the ophthalmic division, most nociceptive stimuli are conveyed by this branch to the trigeminal ganglion (TG) ( 39 ).…”

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

“…The maxillary division (V2) innervates sensitively the mid-part of the face including the upper lip and cheek. Sensitivity of the lower face and motor innervation of the chewing muscles is provided by the mandibular branch (V3) ( 37 , 39 ).…”

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

“…The trigeminal ganglion (TG) consists of 20.000–150.000 pseudo-unipolar neurons with distal axonal branches forming the abovementioned divisions and a proximal axonal branch reaching the TCC in the brainstem ( 39 , 42 ). Fifty percent of small- and medium-sized neurons show CGRP immunoreactivity ( 30 , 43 ) primarily found in sensory neurons and their unmyelinated C-fibers or thinly myelinated Aδ-fibers, not in glial cells.…”

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

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CGRP and Migraine: What Have We Learned From Measuring CGRP in Migraine Patients So Far?

Kamm

2022

Front. Neurol.

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The multi-functional neuropeptide calcitonin gene-related peptide (CGRP) plays a major role in the pathophysiology of migraine. The detection of elevated CGRP levels during acute migraine headache was the first evidence of the importance of the peptide. Since then, elevated CGRP levels have been detected not only during spontaneous and experimentally induced migraine attacks but also interictally. However, the detection of CGRP in peripheral blood shows conflicting results. In this respect, alternative detection methods are needed and have been already proposed. This article summarizes what we have learned from studies investigating CGRP in jugular and peripheral blood and reviews the latest state of research concerning the detection of CGRP in saliva and tear fluid as well as their contribution to our understanding of migraine pathophysiology.

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Section: The Trigeminal Nervementioning

confidence: 99%

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

Section: The Role Of Cgrp In Migraine Pathophysiologymentioning

confidence: 99%

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CGRP and Migraine: What Have We Learned From Measuring CGRP in Migraine Patients So Far?

Kamm

2022

Front. Neurol.

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Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen‐Based Nanomedicines

Wu,

Wang,

Deng

et al. 2024

Adv Healthcare Materials

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Plasmalogens (vinyl‐ether phospholipids) are an emergent class of lipid drugs against various diseases involving neuro‐inflammation, oxidative stress, mitochondrial dysfunction, and altered lipid metabolism. They can activate neurotrophic and neuroprotective signaling pathways but low bioavailabilities limit their efficiency in curing neurodegeneration. Here we created liquid crystalline lipid nanoparticles (LNPs) for protection and non‐invasive intranasal delivery of purified scallop‐derived plasmalogens. Our in vivo results with a transgenic mouse Parkinson's disease (PD) model (characterized by motor impairments and α‐synuclein deposition) demonstrated the crucial importance of LNP composition, which determines the self‐assembled nanostructure type. Vesicle and hexosome nanostructures (characterized by SAXS) displayed different efficacy of the nanomedicine‐mediated recovery of motor function, lipid balance, and transcriptional regulation (e.g., reduced neuro‐inflammation and PD pathogenic gene expression). Intranasal vesicular and hexosomal plasmalogen‐based LNP treatment led to improvement of the behavioral PD symptoms and downregulation of the Il6, Il33, and Tnfa genes. Moreover, RNA‐sequencing and lipidomic analyses established a dramatic effect of hexosomal nanomedicines on PD amelioration, lipid metabolism, and the type and number of responsive transcripts that may be implicated in neuroregeneration.This article is protected by copyright. All rights reserved

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Brain activity associated with taste stimulation: A mechanism for neuroplastic change?

2023

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Purpose Neuroplasticity may be enhanced by increasing brain activation and bloodflow in neural regions relevant to the target behavior. We administered precisely formulated and dosed taste stimuli to determine whether the associated brain activity patterns included areas that underlie swallowing control. Methods Five taste stimuli (unflavored, sour, sweet‐sour, lemon, and orange suspensions) were administered in timing‐regulated and temperature‐controlled 3 mL doses via a customized pump/tubing system to 21 healthy adults during functional magnetic resonance imaging (fMRI). Whole‐brain analyses of fMRI data assessed main effects of taste stimulation as well as differential effects of taste profile. Results Differences in brain activity associated with taste stimulation overall as well as specific stimulus type were observed in key taste and swallowing regions including the orbitofrontal cortex, insula, cingulate, and pre‐ and postcentral gyri. Overall, taste stimulation elicited increased activation in swallowing‐related brain regions compared to unflavored trials. Different patterns of blood oxygen level‐dependent (BOLD) signal were noted by taste profile. For most areas, sweet‐sour and sour trials elicited increases in BOLD compared to unflavored trials within that region, whereas lemon and orange trials yielded reductions in BOLD. This was despite identical concentrations of citric acid and sweetener in the lemon, orange, and sweet‐sour solutions. Conclusions These results suggest that neural activity in swallowing‐relevant regions can be amplified with taste stimuli and may be differentially affected by specific properties within very similar taste profiles. These findings provide critical foundational information for interpreting disparities in previous studies of taste effects on brain activity and swallowing function, defining optimal stimuli to increase brain activity in swallowing‐relevant regions, and harnessing taste to enhance neuroplasticity and recovery for persons with swallowing disorders.

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The trigeminal pathways

Cited by 23 publications

References 179 publications

CGRP and Migraine: What Have We Learned From Measuring CGRP in Migraine Patients So Far?

CGRP and Migraine: What Have We Learned From Measuring CGRP in Migraine Patients So Far?

Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen‐Based Nanomedicines

Brain activity associated with taste stimulation: A mechanism for neuroplastic change?

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