The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

Bann, Samantha J; Ballantine, Ross D.; Cochrane, Stephen A.

doi:10.1039/d0md00413h

Cited by 18 publications

(16 citation statements)

References 38 publications

(130 reference statements)

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“…They may present as many structural variants or isoforms differing in nature of one or more amino acids and fatty acid components, therefore, exhibiting diverse biological activity [12] . Additionally, they can also show electrostatic interactions with membrane lipids and hydrophobic interactions with lipid bilayers [9,11,13] . The peptide‐functionalized supramolecular nanostructures can also result in mechanical and electrostatic changes, reduced surface tension, and disturbances of lipid bilayers structures in target (bacterial and fungal) membrane, hence inducing pore formation, often leading to bacterial death [14] …”

Section: Methodsmentioning

confidence: 99%

“…[12] Additionally, they can also show electrostatic interactions with membrane lipids and hydrophobic interactions with lipid bilayers. [9,11,13] The peptidefunctionalized supramolecular nanostructures can also result in mechanical and electrostatic changes, reduced surface tension, and disturbances of lipid bilayers structures in target (bacterial and fungal) membrane, hence inducing pore formation, often leading to bacterial death. [14] Another class of structurally similar molecules is Peptide amphiphiles (PAs).…”

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confidence: 99%

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Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures

et al. 2022

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Lipopeptide‐inspired lipidation of two short tripeptides, Phe‐Tyr‐β‐Ala and Tyr‐Phe‐β‐Ala leads to a pair of constitutional isomers of short peptide amphiphile (sPA). These two molecules were able to mimic lipopeptides properties and therefore could be used as potential drug delivery vehicles up to target sites. Further, these isomeric peptide amphiphiles were able to synthesize stable silver nanoparticles (AgNPs) in presence of sunlight without using any reducing agents. Interestingly, the presence of AgNPs significantly controls the secondary structures of these two isomeric sPAs and hence their self‐assembly. Therefore, such AgNPs‐sPA nanostructures are further used to develop antibacterial materials. Various microscopy and spectroscopy techniques were used to characterize these nanostructures. The antibacterial analysis demonstrated that owing to high biocompatibility and less cytotoxicity, designed sPA exhibited great potential in locally addressing bacterial infections. Thus, such a strategic design of lipidated tripeptide fragments can be tuned for potential therapeutic value for future applications.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures

et al. 2022

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“…Novel treatment options such as PlyF307 lysine phage against MDR A. baumannii , VTCCBPA43 phage against virulent K. pneumoniae , PlyPa91 and vB_PaeP_PA01EW phages against P. aeruginosa , and Abp95 lytic myoviridae phage against multi-genotypes of carbapenem-resistant A. baumannii were demonstrated in mouse models [ 114 – 118 ]. Tridecaptins, a non-ribosomal lipopeptide, showed a selective bactericidal activity against the gram-negative version of the peptidoglycan precursor lipid II on the outer leaflet of the inner membrane and disrupts the proton-motive force [ 119 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-drug resistant gram-negative bacterial pneumonia: etiology, risk factors, and drug resistance patterns

Assefa

2022

Pneumonia

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Bacterial pneumonia is one of the most serious public health issues owing to its medical and economic costs, which result in increased morbidity and mortality in people of all ages around the world. Furthermore, antimicrobial resistance has risen over time, and the advent of multi-drug resistance in GNB complicates therapy and has a detrimental impact on patient outcomes. The current review aimed to summarize bacterial pneumonia with an emphasis on gram-negative etiology, pathogenesis, risk factors, resistance mechanisms, treatment updates, and vaccine concerns to tackle the problem before it causes a serious consequence. In conclusion, the global prevalence of GNB in CAP was reported 49.7% to 83.1%, whereas in VAP patients ranged between 76.13% to 95.3%. The most commonly reported MDR-GNB causes of pneumonia were A. baumannii, K. pneumoniae, and P. aeruginosa, with A. baumannii isolated particularly in VAP patients and the elderly. In most studies, ampicillin, tetracyclines, amoxicillin-clavulanic acid, cephalosporins, and carbapenems were shown to be highly resistant. Prior MDR-GNB infection, older age, previous use of broad-spectrum antibiotics, high frequency of local antibiotic resistance, prolonged hospital stays, ICU admission, mechanical ventilation, and immunosuppression are associated with the MDR-GNB colonization. S. maltophilia was reported as a severe cause of HAP/VAP in patients with mechanically ventilated and having hematologic malignancy due to its ability of biofilm formation, site adhesion in respiratory devices, and its intrinsic and acquired drug resistance mechanisms. Effective combination therapies targeting PDR strains and drug-resistant genes, antibiofilm agents, gene-based vaccinations, and pathogen-specific lymphocytes should be developed in the future.

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“…The strong antibacterial activity of strain ZF390 might be associated with the production of brevicidine; however, its capability of producing brevicidine B should be further investigated. Tridecaptin is another type of non-ribosomal antibacterial peptide (NRAP) with effective activity against highly problematic strains of Gram-negative bacteria and low levels of resistance development with the potential for safe administration [ 76 ]. All five Paenibacillus strains were found to contain tridecaptin-related gene clusters, but more core biosynthetic genes were predicted in SQR-21 and HY96-2 than in the other three strains ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Genomics Insights into a Novel Biocontrol Agent Paenibacillus peoriae Strain ZF390 against Bacterial Soft Rot

Zhao

Xie

et al. 2022

Biology

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Bacterial soft rot, caused by Pectobacterium brasiliense, can infect several economically important horticultural crops. However, the management strategies available to control this disease are limited. Plant-growth-promoting rhizobacteria (PGPR) have been considered to be promising biocontrol agents. With the aim of obtaining a strain suitable for agricultural applications, 161 strains were isolated from the rhizosphere soil of healthy cucumber plants and screened through plate bioassays and greenhouse tests. Paenibacillus peoriae ZF390 exhibited an eminent control effect against soft rot disease and a broad antagonistic activity spectrum in vitro. Moreover, ZF390 showed good activities of cellulase, protease, and phosphatase and a tolerance of heavy metal. Whole-genome sequencing was performed and annotated to explore the underlying biocontrol mechanisms. Strain ZF390 consists of one 6,193,667 bp circular chromosome and three plasmids. Comparative genome analysis revealed that ZF390 involves ten gene clusters responsible for secondary metabolite antibiotic synthesis, matching its excellent biocontrol activity. Plenty of genes related to plant growth promotion, biofilm formation, and induced systemic resistance were mined to reveal the biocontrol mechanisms that might consist in strain ZF390. Overall, these findings suggest that strain ZF390 could be a potential biocontrol agent in bacterial-soft-rot management, as well as a source of antimicrobial mechanisms for further exploitation.

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The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

Abstract: Tridecaptins are a re-emerging class of non-ribosomal antibacterial peptides (NRAPs) with potent activity against highly problematic strains of Gram-negative bacteria.

Cited by 18 publications

References 38 publications

Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures

Antimicrobial Activity of Silver Nanoparticles Loaded Biomimetic Isomeric Short Lipopeptide Nanostructures

Multi-drug resistant gram-negative bacterial pneumonia: etiology, risk factors, and drug resistance patterns

Comparative Genomics Insights into a Novel Biocontrol Agent Paenibacillus peoriae Strain ZF390 against Bacterial Soft Rot

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