The TRIBECA study: (TRI)fecta (B)ioprosthesis (E)valuation versus (C)arpentier Magna-Ease in (A)ortic position

Colli, Andrea; Marchetto, G; Salizzoni, Stefano; Rinaldi, Mauro; Marco, Luca Di; Pacini, Davide; Bartolomeo, Roberto Di; Nicolini, Francesco; Gherli, Tiziano; Agrifoglio, Marco; Borghetti, Valentino; Khoury, Georgette; Paolis, Marcella De; Zoffoli, Giampaolo; Milardi, Domenico; Amorim, Mário Jorge; Manzan, Erica; Zucchetta, Fabio; Balduzzi, Sara; Gerosa, Gino

doi:10.1093/ejcts/ezv070

Cited by 47 publications

(33 citation statements)

References 24 publications

(33 reference statements)

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“…This is consistent with our findings, which indicated that the presence of postoperative PVL, independently of its severity, was a risk factor for overall long-term mortality (OR 7.5, p = 0.02). These findings are consistent with those reported by other authors [4][5][6][7][8][9]. Our multivariate analysis was performed both on including and on excluding preoperative AR.…”

Section: Discussionsupporting

confidence: 91%

“…Residual aortic regurgitation (AR) due to paravalvular leakage (PVL) following TAVI is associated with increased morbidity and mortality [3,4]. Despite technological advances in TAVI, the presence of any degree of PVL still remains a complication, the incidence of which varies between 2 and 40% [3][4][9][10][11][12][13][14][15][16][17][18][19][20], regardless of prosthesis type [1][2][3][4][5][6][7][8]. However, the correlations among pre-procedural AR, post-procedural PVL and long-term clinical outcomes are not clearly known.…”

Section: Introductionmentioning

confidence: 99%

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Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI?

Colli

Besola

Salizzoni

et al. 2017

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI?

Colli

Besola

Salizzoni

et al. 2017

International Journal of Cardiology

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“…Today, however, perioperative mortality is extremely low (1.8%) at most experienced centers (22). Moreover, adverse events related to heart valve prostheses are extremely rare (23)(24)(25)(26). We calculated a risk score based on preoperative risk factors, ventricular function, and symptomatic status to predict long-term mortality in patients who undergo AVR.…”

Section: Discussionmentioning

confidence: 99%

Risk stratification of severe aortic stenosis according to new guidelines: long term outcomes

et al. 2018

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Background: Current ESC and ACC/AHA guidelines for the management of valvular heart disease assign a class Ia indication for aortic valve replacement (AVR) only to patients with symptomatic severe aortic valve stenosis and asymptomatic patients with depressed left ventricular ejection fraction (LVEF <50%) or positive exercise test. We examined the long-term outcomes for patients undergoing AVR for aortic stenosis over a 11-year period at our institution compared to current international guidelines for AVR. Methods: Patients who had undergone isolated AVR for severe aortic valve stenosis between January 2001 and December 2012 were selected. The population was divided into subgroups based on preoperative LVEF (< or ≥50%) and on presence/absence of symptoms (NYHA =I or ≥II, respectively). Results: We identified 607 patients with a median follow-up (FU) time of 5.75 years (IQR 3.24-8.00 years). The presence of symptoms did not have a significant impact on cardiovascular mortality (P=0.201). Patients with LVEF <50% displayed a higher long-term cardiovascular mortality rate (P=0.015). Multivariate analysis showed that preserved LVEF was a protective factor for asymptomatic patients (P=0.021), while preoperative LVEF did not affect the mortality rate in symptomatic patients (HR 0.88; 95% CI, 0.54-1.44). Correspondingly, asymptomatic patients with reduced LVEF were found to be at a higher risk of long-term mortality compared to the other groups (P=0.011). The only other independent risk factor for death was age (HR 6.46; 95% CI, 2.22-18.76). Conclusions: According to our data, current international class I indications for symptomatic patients ensure good long-term survival, while class I indications for asymptomatic patients with reduced LVEF are associated with poor long-term survival. Our results suggest that early surgery should also be considered also for asymptomatic patients with preserved LVEF, particularly in cases of very low operative risk.

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“…The haemodynamic data are broadly similar to the literature ( 3 , 4 , 5 , 8 , 9 ) in which the reported mean gradients are 9.3–14mmHg for the size 19mm valve, 7.8–12mmHg for the size 21mm valve and 6.9–11 mmHg for the size 23mm valve. There is little comparative work, but others have suggested similar ( 9 , 10 ) and in some cases better ( 10 , 11 ) function than other biological valves particularly for size 19mm valves ( 12 , 13 , 14 ). The proportion with moderate patient–prosthesis mismatch using the classical form of the continuity equation, 17%, compares favourably with the reported prevalence of 20–70% in all types of replacement valves ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

A comparison of two forms of the continuity equation in the Trifecta bovine pericardial aortic valve

et al. 2016

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AimTo compare the classical and simplified form of the continuity equation in small Trifecta valves.MethodsThis is a retrospective analysis of post-operative echocardiograms performed for clinical reasons after implantation of Trifecta bioprosthetic valves.ResultsThere were 60 patients aged 74 (range 38–89) years. For the valves of size 19, 21 and 23mm, the mean gradient was 11.3, 10.7 and 9.7mmHg, respectively. The effective orifice areas by the classical form of the continuity equation were 1.4, 1.7 and 1.9cm2, respectively. There was a good correlation between the two forms of the continuity equation, but they were significantly different using a t-test (P<0.00001). Results using the classical form were a mean 0.11 (s.d. 0.18)cm2 larger than those using the simple formula.ConclusionHaemodynamic function of the Trifecta valve in the small aortic root is good. There are significant differences between the classical and simplified forms of the continuity equation.

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The TRIBECA study: (TRI)fecta (B)ioprosthesis (E)valuation versus (C)arpentier Magna-Ease in (A)ortic position

Cited by 47 publications

References 24 publications

Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI?

Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI?

Risk stratification of severe aortic stenosis according to new guidelines: long term outcomes

A comparison of two forms of the continuity equation in the Trifecta bovine pericardial aortic valve

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