The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Zou, Yuqing; Wang, Shuling; Zhang, Honghua; Gu, Yuxin; Chen, Huijuan; Huang, Zhihua; Yang, Feifei; Li, Wenqi; Chen, Cheng; Men, Lianhui; Tian, Qingchang; Xie, Tian

doi:10.1002/med.21989

Cited by 8 publications

(3 citation statements)

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“…The challenge lies in developing therapies that are effective across the spectrum of colorectal cancer subtypes while avoiding generalized approaches that may not be equally beneficial for all patients. 178,179 The evolution of resistance and issues related to drug specificity underscore the need for a dynamic and adaptable approach in precision medicine implementation against colorectal cancer. Continuous monitoring of a patient's molecular profile throughout the course of treatment, incorporating real-time data, and utilizing advanced diagnostic technologies become crucial components of a successful precision medicine strategy.…”

Section: Integration Of Biomarkermentioning

confidence: 99%

“…Tailoring precision medicine approaches to the specific molecular profile of an individual patient’s tumor requires a comprehensive understanding of the unique molecular characteristics of each subtype. The challenge lies in developing therapies that are effective across the spectrum of colorectal cancer subtypes while avoiding generalized approaches that may not be equally beneficial for all patients. , …”

Section: Challenges and Considerations In Precision Medicine Implemen...mentioning

confidence: 99%

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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Integration Of Biomarkermentioning

confidence: 99%

Section: Challenges and Considerations In Precision Medicine Implemen...mentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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“…[ 5 ] TCM were applying in CRC to anti-tumor through promoted cancer cell apoptosis, inhibited cancer metastasis, and reduced drug resistance and side effects and regulated intestinal flora. [ 6 ] However, the specific mechanism underlying TCM was still not clear.…”

Section: Introductionmentioning

confidence: 99%

Prediction of potential mechanisms of rhubarb therapy for colorectal cancer based on network pharmacological analysis and molecular docking

Yang,

Li,

Zhang

et al. 2024

Medicine

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The objective of this study was to investigate the potential targets and mechanism of Rheum palmatum L in the treatment of colorectal cancer based on the network pharmacology and molecular docking, which could provide the theoretical basis for clinical applications. The potential components were screened using TCMSP database and articles. The gene targets of colorectal cancer were screened through the Genecards database and Online Mendelian Inheritance in Man database. Then, the common targets of components and colorectal cancer were used to construct the network diagram of active components and targets in Cytoscape 3.7.0. The protein-protein interaction (PPI) diagram was generated using String database, and the targets were further analyzed by gene ontology and Kyoto Encyclopedia of Genes and Genomes. Molecular docking between gene targets and active components was analyzed via AutoDock, and visualized through PyMol. Among this study, main targets might be TP53, EGF, MYC, CASP3, JUN, PTGS2, HSP90AA1, MMP9, ESR1, PPARG. And 10 key elements might associate with them, such as aloe-emodin, beta-sitosterol, gallic acid, eupatin, emodin, physcion, cis-resveratrol, rhein, crysophanol, catechin. The treatment process was found to involve nitrogen metabolism, p53 signaling pathway, and various cancer related pathway, as well as the AGE-RAGE signaling pathway, estrogen signaling pathway, interleukin-17 signaling pathway and thyroid hormone signaling pathway. The molecular docking was verified the combination between key components and their respective target proteins. Network pharmacological analysis demonstrated that R palmatum was could regulated p53, AGE-RAGE, interleukin-17 and related signaling pathway in colorectal cancer, which might provide a scientific basis of mechanism.

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Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway

Mo,

Li,

Zhang

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Gallbladder cancer (GBC) is a common malignant cancer in the biliary system, which poses a serious threat to human health. It is urgent to explore ideal drugs for the treatment of GBC. Matrine is the main active ingredient of sophora avescentis, with a wide range of biological activities encompassing antiin ammatory, antiviral, immunomodulatory and anti-tumor. However, the underlying mechanism by which Matrine treats GBC is still unclear. The purpose of this study is to investigate the anti-tumor effects of Matrine on GBC in vivo and in vitro, and to clarify the potential regulatory mechanisms. Here, in this primer, we found that Matrine has a signi cant killing effect on GBC through CCK8 and ow cytometry, including arrest of cell cycle, inhibition of GBC cell, and induction of apoptosis. Further studies in vivo con rmed that the inhibitory function of Matrine on tumor growth in NOZ xenografted nude mouse. At the same time, Matrine also signi cantly suppressed the migration and invasion of GBC cells through scratch and Transwell experiments. In addition, by detecting the mRNA and protein levels of epithelialmesenchymal transition (EMT) and matrix metalloproteinases, Matrine furtherly substantiated the suppression of invasion and migration of GBC. From a mechanistic perspective, Matrine effectively decreased the abundance of p-PI3K and p-AKT protein in vivo and in vitro. More importantly, PI3K activator (740 Y-P) antagonized the anti-tumor effect of Matrine, while PI3K inhibitor (LY294002) increased the sensitivity of Matrine for GBC. Based on the above ndings, we conclude that Matrine inhibits the invasion and migration of GBC by regulating PI3K/AKT signaling pathway. Our results indicate the crucial role and regulatory mechanism of Matrine in suppressing the growth of GBC, which provides a theoretical basis for Matrine to be a candidate drug for the treatment and research of GBC.Cell culture GBC-SD cell line, a human GBC cell line, was purchased from Procell (Wuhan, China, Cat. No. CL-0085), while NOZ cell line (Cat. No. MZ-2106) of human GBC and HGBEC cell line (Cat. No. MZ-3197) of human gallbladder epithelial immortalized was both obtained from Ningbo, China. Whelab Bioscience Limited Corporation (Shanghai, China, Cat. No. C1546) provided SGC-996 cell line of the other human GBC. NOZ cells were cultured in DMEM medium containing 10% concentrations of fetal bovine serum (FBS, Wisent, Cat. No. 085-150), 100 U/ml penicillin (Beyotime, Cat. No. C0222), and 100 µg/ml streptomycin (Beyotime, Cat. No. C0222), while SGC-996 and GBC-SD cells were maintained in PRMI 1640 complete medium. The specialized medium was used for culturing HGBEC cells. All cells were cultured at 37 ℃ with 5% carbon dioxide. CCK8 assayCell viability was evaluated according to Cell Counting Kit-8 (MedChemExpress, Cat. No. HY-K0301) provided by the vender. The cells (HGBEC, GBC-SD, NOZ and SGC-996) were seeded in 96-well plates overnight and treated with different concentrations of Matrine (0-80 µM) for 12-72 hours, or treated with LY294002 (0-8...

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The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Cited by 8 publications

References 270 publications

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Prediction of potential mechanisms of rhubarb therapy for colorectal cancer based on network pharmacological analysis and molecular docking

Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway

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