The Tree Shrew as a Model for Cancer Research

Lu, Tao; Peng, Hongmei; Zhong, Liping; Wu, Pan; Deng, Zhiming; Huang, Yong

doi:10.3389/fonc.2021.653236

Cited by 10 publications

(8 citation statements)

References 95 publications

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“…Due to this close relation, some molecular tools, such as anti-human antibodies, cross-react with tree shrew proteins [118]. As this species is increasingly used in cancer research to model human carcinogenesis, more tools are in development, carrying promise for the tree shrew as an HSV infection model [123].…”

Section: Tree Shrewsmentioning

confidence: 99%

Models of Herpes Simplex Virus Latency

Canova,

Charron,

Leib

2024

Viruses

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Our current understanding of HSV latency is based on a variety of clinical observations, and in vivo, ex vivo, and in vitro model systems, each with unique advantages and drawbacks. The criteria for authentically modeling HSV latency include the ability to easily manipulate host genetics and biological pathways, as well as mimicking the immune response and viral pathogenesis in human infections. Although realistically modeling HSV latency is necessary when choosing a model, the cost, time requirement, ethical constraints, and reagent availability are also equally important. Presently, there remains a pressing need for in vivo models that more closely recapitulate human HSV infection. While the current in vivo, ex vivo, and in vitro models used to study HSV latency have limitations, they provide further insights that add to our understanding of latency. In vivo models have shed light on natural infection routes and the interplay between the host immune response and the virus during latency, while in vitro models have been invaluable in elucidating molecular pathways involved in latency. Below, we review the relative advantages and disadvantages of current HSV models and highlight insights gained through each.

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Section: Tree Shrewsmentioning

confidence: 99%

Models of Herpes Simplex Virus Latency

Canova,

Charron,

Leib

2024

Viruses

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“…Tree shrews have emerged as an interesting tumor model organism. With a genome highly similar to that of primates, small size, ease of breeding, and short experimental period, tree shrews may be more widely used for tumor modeling [18,19]. Currently, the use of tree shrews in tumor research is still in its early stages and primarily focused on liver and breast cancers [19].…”

Section: Large Mammalsmentioning

confidence: 99%

Zebrafish in Lung Cancer Research

Wu,

Hua,

et al. 2023

Cancers

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Zebrafish is increasingly used as a model organism for cancer research because of its genetic and physiological similarities to humans. Modeling lung cancer (LC) in zebrafish has received significant attention. This review focuses on the insights gained from using zebrafish in LC research. These insights range from investigating the genetic and molecular mechanisms that contribute to the development and progression of LC to identifying potential drug targets, testing the efficacy and toxicity of new therapies, and applying zebrafish for personalized medicine studies. This review provides a comprehensive overview of the current state of LC research performed using zebrafish, highlights the advantages and limitations of this model organism, and discusses future directions in the field.

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“…In the past, researchers across the world have attempted to establish tree shrew models of hepatitis B virus and hepatitis C virus infections [8][9][10][11], SARS-CoV-2 infection [12], Kaposi's sarcoma-associated herpesvirus infection [13], influenza viruses [14,15], and dengue virus [16] infections. Tree shrews were also used to create animal models of depression [17], osteonecrosis [18], and cancer [19,20]. Studies on tree shrews have also offered new insights into the fundamental mechanism of development of the visual system and brain function [21], as well as social avoidance and cooperative behavior [22,23].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis)

Chen

et al. 2022

Animals

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The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the Chinese tree shrew; however, we have been hindered by a low survival rate of inbred pups. Here, we report our artificial rearing (AR) of Chinese tree shrew pups using four different milk substitutes: the formula described by Tsang and Collins (milk TC) and three commercially available milk substitutes intended for possums (milk A and milk C) and for guinea pigs (milk B). We compared the effects of these milk substitutes and maternal milk on the daily milk consumption, growth performance, and survival of the pups. We also assessed the life span and reproductive performance of the F1 individuals given the best milk substitute as compared to the maternally reared (MR) pups. Milk B was found to be appropriate for AR. Pups fed with milk B had a high survival rate at the weaning age compared to those fed with the other milk substitutes. The AR pups fed with milk B had a life span similar to that of MR pups. AR females fed with milk B had an earlier age of the first reproduction, a larger number of litters, and a higher rate of survival of the offspring at the weaning age compared with the MR females. The successful optimization of a milk substitute for AR of Chinese tree shrew pups will undoubtedly facilitate the wide usage of this experimental animal.

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The Tree Shrew as a Model for Cancer Research

Cited by 10 publications

References 95 publications

Models of Herpes Simplex Virus Latency

Models of Herpes Simplex Virus Latency

Zebrafish in Lung Cancer Research

Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis)

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