The Treatment Time in Psoriasis*

MacLennan, Alex.; Hellier, F. F.

doi:10.1111/j.1365-2133.1961.tb14996.x

Cited by 42 publications

(10 citation statements)

References 3 publications

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“…However, in hospitalized patients the cutaneous teaction to this damage may be counteracted by the topical tieatment applied immediately afteiwards. Nevertheless, it is of interest to point out that there are also some in-patients who show poor or no response to the intensive treatment (MacLennan & Hellier 1961).…”

mentioning

confidence: 99%

Do Excoriations in Psoriasis Delay or Prevent the Effect of Topical Treatment?

Brody

1975

J Cutan Pathol

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Topical treatment of a number of out-patients with psoriasis vulgaris resulted in reduced induration and diminished thickness of the layer of scales but complete involution was not obtained. A sequential photographic study of the macroscopic appearance of the lesions over a 3-month period of treatment revealed that artificially produced excoriations and a horny layer without scales were prominent features. The view is put forward that the cutaneous reaction to the injury probably elicited by the excoriations, together with an unsatisfactory treatment, may give rise to tissue changes which counteract the effect of topical treatment.

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mentioning

confidence: 99%

Do Excoriations in Psoriasis Delay or Prevent the Effect of Topical Treatment?

Brody

1975

J Cutan Pathol

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“…6 Other series have given average clearance times between 11 and 25 days. MacLennan and Hellier's series of 2120 patients treated with dithranol reported clearance times of 95% with an average of 15.2 days as inpatients.…”

Section: Discussionmentioning

confidence: 99%

“…MacLennan and Hellier's series of 2120 patients treated with dithranol reported clearance times of 95% with an average of 15.2 days as inpatients. 6 Other series have given average clearance times between 11 and 25 days. [7][8][9][10][11] The regime used in this study is a modification of Ingram's original regime.…”

Section: Discussionmentioning

confidence: 99%

Twice-daily vs. once-daily inpatient dithranol for psoriasis

Kirkup

Sabroe

Kavanagh

et al. 2002

Clinical and Experimental Dermatology

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The aim of this study was to compare the efficacy and tolerability of twice-daily vs. once-daily regimes of dithranol (anthralin) in Lassar's paste. Over a 4-year period, 61 inpatients with stable plaque psoriasis gave informed consent and entered a randomized controlled trial, having twice or once-daily application of dithranol in Lassar's paste as part of otherwise standard Ingram's regime. Primary outcome measurements were time required in hospital, nursing time, changes in total body surface area affected by psoriasis and thickness of a target plaque and in some patients, an assessment of the recurrence of psoriasis. Doctors were blinded as to the regime being used. At entry, mean patient age, lesional surface area and target plaque thickness were comparable in both groups and no patient had received systemic therapy in the preceding 3 months. Forty-two patients completed the study, two (11%) in the twice-daily group withdrawing due to skin irritation or 'burning'. Mean lesional surface area and target plaque thickness were similar in both groups at hospital discharge. Mean (+/- SD) time spent in hospital was not significantly different in each group, being 13.3 (+/- 6.2) days and 13.9 (+/- 4.5) days for the twice-daily and once-daily groups, respectively (P = 0.36). Duration of hospitalization did not correlate with surface area or plaque thickness on admission. Mean (+/- SD) nursing time spent on treatment was significantly greater in the twice-daily group, at 0.82 (+/- 0.33) hours per day compared with 0.51(+/- 0.25) hours per day in the once-daily group. Relapse rate at 6 months was not different between the two groups.

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“…29 Uncertainty about definitions of end points and the comparability of treatment protocols has bedeviled comparative studies, but the coal tar-ultraviolet B and coal tar-ultraviolet B-anthralin regimens are roughly equal in terms of efficacy, speed of action, and cost effectiveness. 30,31 Anthralin is oxidized to colored products that stain the skin and *Includes Koebner's phenomenon (the development of a lesion of psoriasis at the site of a previous injury), as shown in Figure 1. 6 Wolf et al 7 Lazarus and Gilgor 8 Baker 9 Katayama and Kawada 10 Psychological stress Farber et al, 11 Arnetz et al, 12 clothes brown or purple, and it irritates perilesional skin because of free-radical formation; both side effects can be reduced by incorporating free-radical scavengers and antioxidants into the treatment.…”

Section: Anthralinmentioning

confidence: 99%