The treatment of the nonedematous nephrotic child with acth

Krämer, Benjamin; Goldman, Harold S.; Cason, Louise

doi:10.1016/s0022-3476(52)80299-9

Cited by 21 publications

(6 citation statements)

References 8 publications

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“…These concepts of nephrosis are based largely upon histological evidence of damage to different parts of the nephron, but to many other writers nephrosis is a clinical rather than a histological entity, a view which has been well summarized by Kramer, Goldman and Cason (1952) in the following terms:…”

mentioning

confidence: 99%

The Natural History of Nephrosis

Rm¹

1957

Archives of Disease in Childhood

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confidence: 99%

The Natural History of Nephrosis

Rm¹

1957

Archives of Disease in Childhood

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“…In many patients with the nephrotic syndrome, proteinuria diminished during or after treatment with corticotropin (ACTH) or Cortisone (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Further, in most patients so treated GFR increased (6)(7)(8)12).…”

mentioning

confidence: 99%

The Effect of Corticotropin (ACTH) on Glomerular Permeability to Albumin in Children with the Nephrotic Syndrome 12

Lauson¹,

Forman²,

McNamara³

et al. 1954

J. Clin. Invest.

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Present evidence indicates that proteinuria in patients with the nephrotic syndrome is the result of increased permeability of the glomerular capillary walls to proteins, particularly to albumin (1, 2). A rough indication of the permeability to albumin, relative to permeability to water, is provided by the ratio of the concentration of albumin in glomerular fluid to that in plasma. Assuming that no albumin is excreted by the tubules, the rate of albumin excretion (in mg. per min.) divided by the rate of glomerular filtration of water (GFR, in ml. per min.) represents the lowest possible concentration of albumin in glomerular fluid (in mg. per ml.) ; if some albumin is reabsorbed by the tubules, as seems likely, the actual concentration of albumin in glomerular fluid would be greater than this calculated value. If it is accepted that the clearance of inulin (CIN) is equivalent to GFR in children with the nephrotic syndrome (3), it follows that the renal clearance of albumin (CALB) divided by CIN, i.e., CALB/CIN, represents the minimum ratio of the albumin concentration in glomerular fluid to that in plasma. Chinard, Lauson, and Eder (4) showed that in patients with the nephrotic syndrome the renal clearance of the blue dye, T-1824 (CT_1824), was somewhat less than but approximately proportional to CALB. It would appear, therefore, that where large changes in permeability are expected CT_1824should be a satisfactory substitute for CALB. The

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“…In the adults with severe hypoal¬ buminemia, the renal disease in one case ( 21 ) was associated with primary amyloidosis diagnosed by biopsy. In six cases (14, 15,16,18,20, and 22) the disease was described as insidious in onset. In case 19, the onset of the disease occurred during desensitization injections for hay fever.…”

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confidence: 99%