The Treatment of the Nephrotic Syndrome with Steroids in Children and Adults

Differential Protein Clearances in Indian Children with the Nephrotic Syndrome

“…In our patients with the nephrotic syndrome, there was a significant depression of serum fBlc concentration which involved both those with good and poor steroid response since, though there was a tendency for those with histological abnormality and for the poor responders to give lower values, this small trend was not significant. Though there has been debate about serum complement levels in steroid sensitive nephrotic syndrome, and there is evidence that it may be an immunological disease (Lange et al, 1957;Ngu, Barratt, and Soothill, 1970), the latter found no difference between the serum lc levels in European steroid sensitive relapsing nephrotic syndrome, and in the healthy European children whose data are plotted in Fig. 3.…”

Minimal Change Disease in Adults

“…Minimal change disease (MCD) was first coined as an entity in 1913 (Munk 1946). By 1931, the term "nephrotic syndrome" was introduced formally in the medical lexicon (Leiter 1930) and by the 1950s, there were multiple studies looking at use of corticosteroids or adrenocorticotropic hormone (ACTH) in the treatment of idiopathic nephrotic syndrome in adults and children (Barnett et al 1951;Lange et al 1957).…”

Alternate-day prednisone is more effective than intermittent prednisone in frequently relapsing nephrotic syndrome

“…The first was introduced by Lange et al in 1953 [23] and consists of steroid administration in divided doses on three or four consecutive days followed by a steroid-free interval [24,25]. In children with frequently relapsing MCNS two types of interrupted long-term regimens have been mainly proposed: i.e., the intermittent schedule and the alternateday schedule.…”