The treatment of rheumatoid arthritis during pregnancy

Partlett, Rosamund; Roussou, Euthalia

doi:10.1007/s00296-010-1643-7

Cited by 29 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Use of HCQ during pregnancy at the low doses used for malaria prophylaxis does not increase the risk of congenital abnormalities or pregnancy loss [79]. When used as a DMARD at much higher doses, the continuation of this drug during pregnancy has long been controversial and the FDA classifies HCQ in Category C. This controversy was mainly due to reports on retinal toxicity and ototoxicity observed after treatment with chloroquine [80].…”

Section: Drug Treatment Of Ra During Preconception Pregnancy and Lacmentioning

confidence: 99%

See 1 more Smart Citation

Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use

et al. 2011

View full text Add to dashboard Cite

It has long been known that pregnancy and childbirth have a profound effect on the disease activity of rheumatic diseases. For clinicians, the management of patients with RA wishing to become pregnant involves the challenge of keeping disease activity under control and adequately adapting drug therapy during pregnancy and post-partum. This article aims to summarize the current evidence on the evolution of RA disease activity during and after pregnancy and the use of anti-rheumatic drugs around this period. Of recent interest is the potential use of anti-TNF compounds in the preconception period and during pregnancy. Accumulating experience with anti-TNF therapy in other immune-mediated inflammatory diseases, such as Crohn’s disease, provides useful insights for the use of TNF blockade in pregnant women with RA, or RA patients wishing to become pregnant.

show abstract

Section: Drug Treatment Of Ra During Preconception Pregnancy and Lacmentioning

confidence: 99%

“…Due to its long-lasting effects, it is recommended that rituximab treatment be stopped 1 year before conception [79]. Currently data on secretion of rituximab in breast milk are still lacking, hence the safety of this biological during lactation cannot be guaranteed [119].…”

Section: Drug Treatment Of Ra During Preconception Pregnancy and Lacmentioning

confidence: 99%

Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Częściej występuje u kobiet, głównie w wieku rozrodczym, dlatego istotnym problemem klinicznym może się stać przygotowanie i prowadzenie cią-ży u kobiet chorych na RZS. Większość syntetycznych leków modyfikujących przebieg choroby (LMPCh) stosowanych w RZS może niekorzystnie wpływać na przebieg ciąży [1,2]. Niewiele jest obserwacji dotyczących przebiegu ciąży bezpośrednio po lub w trakcie terapii biologicznymi LMPCh, któ-re stanowią najnowszą opcję terapeutyczną, zwłaszcza u chorych nieodpowiadających na leczenie tradycyjne [3].…”

Section: Wstępunclassified

“…Badania prospektywne wykazują jednak bardzo zróżnicowany wpływ ciąży na aktywność RZS. Najczęściej, u ok. 2/3 chorych, obserwuje się umiarkowaną poprawę (zmniejszenie liczby stawów obrzękniętych i bolesnych), a tylko u 16% pełną remisję [1,2]. Największy wpływ ciąży na aktywność RZS wystę-puje u chorych z dużą lub umiarkowaną aktywnością choroby, w pierwszym trymestrze ciąży [2].…”

Section: Dyskusjaunclassified

“…Leczenie niektó-rymi LMPCh powinno być przerwane: MTX na 3-6 miesięcy przed zapłodnieniem, leflunomidem (LEF) na 2 lata przed ciążą (w razie krótszego okresu konieczna jest procedura wypłukiwania cholestyraminą). Podczas ciąży, jeżeli istnieją wskazania, można stosować GKS (prednizon do 15 mg/dobę -bezpieczna dawka), sulfasalazynę (suplementując kwas foliowy), leki antymalaryczne (bezpieczniejsza jest hydroksychlorochina), azatioprynę i CSA (w celu podtrzymania remisji w ciąży) [1,2]. W okresie poprzedzającym ciążę u chorych z agresywną postacią RZS terapią z wyboru jest leczenie biologiczne, najczęściej inhibitorami czynnika martwicy nowotworów (tumor necrosis factor -TNF).…”

Section: Dyskusjaunclassified

See 1 more Smart Citation

Selected problems of biologic therapy in rheumatoid arthritis patients – pregnancy during therapy. Case reports

Jeleniewicz¹,

Targońska-Stępniak²,

Wielosz³

et al. 2013

Reumatologia

View full text Add to dashboard Cite

Przygotowanie do zajścia w ciążę i jej prowadzenie u pacjentek chorych na reumatoidalne zapalenie stawów (RZS) stanowi istotny problem kliniczny. Niekorzystny wpływ na przebieg ciąży może mieć sam proces zapalny i powikłania narządowe RZS, ale również stosowane leczenie. Niewiele jest informacji dotyczących przebiegu ciąży u chorych na RZS leczonych lekami biologicznymi. W pracy opisano dwie chore na RZS, które w trakcie terapii lekami biologicznymi zaszły w ciążę.

show abstract

“r/Thritis”, Pregnancy, and Parenting: A Qualitative Descriptive Study of Reddit Forums to Explore Information Needs and Concerns of Women With Rheumatoid Arthritis

Chew

Rebić

Baldwin

et al. 2019

ACR Open Rheumatology

View full text Add to dashboard Cite

ObjectiveRheumatoid arthritis (RA) disproportionately affects more women than men, often striking during childbearing years. Because the Internet, particularly social media, is increasingly used by patients with chronic conditions seeking and sharing information, our objective was to conduct a qualitative descriptive study of threads on the social news website, Reddit, to understand the information needs and concerns of women with RA regarding pregnancy and parenting.MethodsWe searched threads (original posts and responses) on three subreddit sites, “r/Thritis,” “r/Rheumatoid,” and “r/BabyBumps,” over a 10‐year period between October 27, 2008, and October 27, 2018. All threads were reviewed, and those that specifically mentioned having RA and fertility/family planning, pregnancy/reproduction, and/or parenting/having children were included. We applied a thematic analysis to the threads, which involved initial line‐by‐line coding, clustering of codes into subcategories and categories, and abstraction into final themes.ResultsWe identified 87 threads and included 59 for qualitative analysis. The thematic analysis led to the identification of five themes. Theme one (finding a community) captures motivations for seeking information online. Themes two (making decisions about pregnancy and having children) and three (worrying about the impacts of arthritis on pregnancy and parenting) capture women's concerns and thought processes. Themes four (information needs for managing arthritis throughout the perinatal period) and five (pregnancy information and resources for women with arthritis) describe the community's specific informational needs.ConclusionA qualitative analysis of publicly available threads about the relationship between RA and issues of pregnancy and parenting identified areas of concern and further information need. These forums also provided an online community where women with RA sought social support and encouragement. Altogether, findings speak to the importance of supporting the information and care needs of women with RA who are pregnant or considering pregnancy.

show abstract

The treatment of rheumatoid arthritis during pregnancy

Cited by 29 publications

References 11 publications

Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use

Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use

Selected problems of biologic therapy in rheumatoid arthritis patients – pregnancy during therapy. Case reports

“r/Thritis”, Pregnancy, and Parenting: A Qualitative Descriptive Study of Reddit Forums to Explore Information Needs and Concerns of Women With Rheumatoid Arthritis

Contact Info

Product

Resources

About