The Treatment of Psoriasis With Vitamin a and Triamcinolone*.

Whittle, C. H.; Woods, B.; Grange, Rémi; Carpenter, Rick; Casbold, J. A.

doi:10.1111/j.1365-2133.1961.tb14995.x

Cited by 12 publications

(4 citation statements)

References 19 publications

(3 reference statements)

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“…HIGH dosage vitamin A therapy has been reported to be beneficial in a number of skin disorders associated with dyskeratosis such as ichthyosis, pityriasis rubra pilaris, Darier's disease and follicular hyperkeratosis (Burgoon et al, 1963). However, vitamin A has not been found to be of value in the treatment of psoriasis (Burgoon et al, 1963;Pucinelli and Belione, 1948), although topical vitamin A and triamcinolone ointment has been reported to be better than triamcinolone ointment alone (Whittle et al, 1961).…”

mentioning

confidence: 99%

Effect of Eetinoic Acid in Psoriasis

1970

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SUMMARY.— The effect of topical retinoic acid on the clinical and histological features and mitotic counts of lesions in 12 patients with psoriasis have been studied for a 2‐week period. Serial biopsies were performed on lesions treated with retinoic acid in all 12 patients; control lesions treated with unmedicated ointment base were similarly biopsied in 7. There was a significant clinical improvement in 11 of the 12 patients treated with retinoic acid, and in all these patients it was greater than that achieved in the control lesions. Reformation of the granular layer, which was previously absent or only partially formed, occurred in 6 of the 12 psoriatic lesions treated with retinoic acid, but in none of the controls. Mitotic counts for the treated group fell after the 2‐week period, but not in the controls. Topical retinoic acid would seem to be of therapeutic value in the treatment of psoriasis. The possible mechanisms of action are discussed.

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confidence: 99%

Effect of Eetinoic Acid in Psoriasis

1970

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“…Thus, the two drugs seem to enhance their antipsoriatic effect rather than to neutralize each other. Similarly, better results have been reported by Whittle et al (1961) with combined treatment with ointments containing vitamin A and triamcinolone.…”

Section: Clinical Efficacy Of the Ra Creamsmentioning

confidence: 65%

Retinoic acid in psoriasis: its value for topical therapy with and without corticosteroids

Orfanos

Schmidt

Mahrle

et al. 2006

British Journal of Dermatology

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SUMMARY Topical application of retinoic acid (RA, 0·1 and 0·3% in a cream base) in psoriasis over 3 weeks showed that low therapeutic effect and frequent irritation limit considerably its usefulness in this disease. Of twenty treated patients, six had irritation warranting discontinuation of therapy, thirteen showed improvement, but none cleared completely. However, the therapeutic value was increased and the incidence of irritation was reduced if corticosteroids (CO) were added to RA. Of twenty‐four patients treated with RA + CO, eighteen were improved and four cleared completely. Combined treatment seemed also to be more effective than CO alone in the same vehicle. Light and electron microscopic studies after combined treatment showed reappearance of the keratohyaline, disappearance of parakeratosis and acanthosis and improvement of the dilated and fenestrated psoriatic capillaries. However, the number of tonofilaments was still decreased and some dermal changes were still present.

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“…In referring to our closed sequential clinical trial (Whittle et al, 1961) using Armitage's model (1954,1957), which showed statistically the superiority of Vitamin A-plus-triamcinolone to triamcinolone, applied topically, P < 0-05 (not " P > 0-05 "-a misprint! ), the authors were surprised that such a result obtained using triamcinolone and retinol (Vitamin A) was not more energetically followed up ".…”

Section: Retinoic Acid In the Treatment Of Psoriasismentioning

confidence: 99%

Retinoic Acid in the Treatment of Psoriasis

Whittle

1972

Br J Dermatol

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The Treatment of Psoriasis With Vitamin a and Triamcinolone*.

Cited by 12 publications

References 19 publications

Effect of Eetinoic Acid in Psoriasis

Effect of Eetinoic Acid in Psoriasis

Retinoic acid in psoriasis: its value for topical therapy with and without corticosteroids

Retinoic Acid in the Treatment of Psoriasis

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