The Treatment of Precocious Puberty With Cyproterone Acetate

Abstract

Nine patients (8 girls and 1 boy) suffering from precocious puberty received daily 100 mg/m2 cyproterone acetate orally. This treatment inhibited the vaginal bleeding; breast-size and the axillary hair and pubic hair did not further increase. The height increment per year and the bone maturation slowed down. The urinary excretion of androgens was temporarily diminished. It is probable that the growth prognosis could be improved by the administration of cyproterone acetate.

The effects of cyproterone acetate on statural growth in children with precocious puberty

“…The mean BP predictions chan¬ ged from 150.4 before to 153.0 cm in 9 patients with IPP after cessation of therapy. A probable improvement of height predictions was also sup¬ posed by Rager et al (1973) in 9 patients with precocious puberty after administration of CPA at daily doses of 100 mg/m2. Bossi et al (1973) described improved height predictions in 5 pa¬ tients with precocity treated with mean daily doses of 60 mg CPA/m2.…”

“…CPA had subsequently been introduced for the treatment of precocious puberty in boys and girls, irrespective of aetiology (Helge et al 1969;Rager et al 1973;Bossi et al 1973;Werder et al 1974;Kauli et al 1976;Stahnke et al 1979;Lyon et al 1985).…”

The effect of cyproterone acetate on the growth of children with central precocious puberty

“…Because of the sex incidence of central precocious puberty, most of the evidence for the support of a beneficial effect of cyproterone acetate on growth has been accumulated in girls. The initial rise in growth potential of untreated girls with central precocious puberty probably accounts for the early reports of the beneficial effect of cyproterone acetate [1,2,11,18,20] and emphasises that long treatment periods must be used in order to assess an effect on growth potential. There was no significant difference between height SDS for bone age at the beginning and end of observation in either treated or untreated groups.…”

“…There has been considerable controversy about the effect of cyproterone acetate on the growth of children with central precocious puberty. In this respect it has been claimed that cyproterone acetate improved growth prognosis [1,2,18,20], improved growth prognosis if the bone age was less than 11 "years" [11] and alternatively had no effect on growth prognosis [29].…”

The Effect of Cyproterone Acetate on the Plasma Gonadotrophin Response to Gonadotrophin Releasing Hormone

“…The acetate derivative produces a fall in plasma testosterone levels in man (Murray et al 1973) and has been used in the treatment of hypersexuality (Laschet 8c Laschet 1967), sexual precocity (Rager et al 1973) and hirsutism (Hammerstein 8c Cupceancu 1969;Ismail et al 1974).…”