The treatment of pelvic soft tissue radiation necrosis with hyperbaric oxygen

Williams, James A.; Clarke, David J.; Dennis, William A.; Dennis, Edward J.; Smith, Sarahn

doi:10.1016/s0002-9378(11)91421-5

Cited by 45 publications

(23 citation statements)

References 7 publications

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“…Williams et al 21 prospectively examined the therapeutic effects of HBO 2 on radiation-induced soft-tissue necrosis in 14 patients who had previously received treatment for a gynecologic malignancy. Fourteen patients whose necrotic wounds failed to heal after 3 months of conservative therapy underwent 15 courses of HBO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…From among the 13 full-text articles, two randomized controlled trials 19,20 , eleven nonrandomized studies [21][22][23][24][25][26][27][28][29][30][31] , and five additional supporting documents 12,[32][33][34][35] representing indirect evidence, were considered eligible for inclusion. They comprise the evidence base for the systematic review of the literature.…”

Section: Literature Search Strategymentioning

confidence: 99%

“…Table i summarizes key studies, which include retrospective, prospective, and case studies and randomized controlled trials. Further details of the studies and other relevant publications 12,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] are available on the Current Oncology Web site.…”

Section: Synthesizing the Evidencementioning

confidence: 99%

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Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

et al. 2011

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Background: Late radiation tissue injury is a serious complication of radiotherapy for patients with gynecologic malignancies. Strategies for managing pain and other clinical features have limited efficacy; however, hyperbaric oxygen therapy (HBO2) may be an effective option for some patients. Methods: In a systematic review of the literature, the Ovid medline, embase, Cochrane Library, National Guidelines Clearinghouse, and Canadian Medical Association Infobase databases were searched to June 2009 for clinical practice guidelines, systematic reviews, randomized controlled trials, or other relevant evidence. Studies that did not evaluate soft tissue necrosis, cystitis, proctitis, bone necrosis, and other complications were excluded. Results: Two randomized trials, eleven nonrandomized studies, and five supporting documents comprise the evidence base. In addition, information on the harms and safety of treatment with HBO2 were reported in three additional sources. There is modest direct evidence and emerging indirect evidence that the use of HBO2 is broadly effective for late radiation tissue injury of the pelvis in women treated for gynecologic malignancies. Conclusions: Based on the evidence and expert consensus opinion, (1) HBO2 is likely effective for late radiation tissue injury of the pelvis, with demonstrated efficacy specifically for radiation damage to the anus and rectum; (2) the main indication for HBO2 therapy in gynecologic oncology is in the management of otherwise refractory chronic radiation injury; (3) HBO2 may provide symptomatic benefit in certain clinical settings (for example, cystitis, soft-tissue necrosis, and osteonecrosis); (4) and HBO2 may reduce the complications of gynecologic surgery in patients undergoing surgical removal of necrosis.

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Section: Resultsmentioning

confidence: 99%

Section: Literature Search Strategymentioning

confidence: 99%

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Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

et al. 2011

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“…Table 4 displays an overview of published data on HBO treatment for late effects of pelvic irradiation treatment. Williams et al [79] obtained healing of vaginal necrosis in 13 out of 14 patients as well as Feldmeier & Hampson [17], who reported encouraging results, particularly in patients who had received a sufficient number of HBO sessions. Radiation proctitis, mostly obtained following prostate cancer irradiation, is very disabling for the patients with symptoms like local pain, urgency, rectal discharge or bleeding.…”

Section: Minmentioning

confidence: 96%

“…Radiation-induced pelvic late effects and radiation-induced proctitis [3,9,20,24,42,56,73,75,79,82,83]. Table 4 displays an overview of published data on HBO treatment for late effects of pelvic irradiation treatment.…”

Section: Minmentioning

confidence: 99%

Hyperbaric Oxygen and Radiotherapy

et al. 2005

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Hyperbaric Oxygen for Treating Wounds

Wang

Schwaitzberg²,

Berliner³

et al. 2003

Arch Surg

153

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Objective:To determine whether hyperbaric oxygen (HBO) therapy is an effective adjunct treatment for hypoxic wounds. Methods:We identified studies from technology assessment reports on HBO and a MEDLINE search from mid-1998 to August 2001. We accepted randomized controlled trials (RCTs), cohorts, and case series that reported original data, included at least 5 patients, evaluated the use of HBO for wound care, and reported clinical outcomes. Demographics, wound conditions, HBO regimen, adverse events, and major clinical outcomes were extracted from each study.

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The treatment of pelvic soft tissue radiation necrosis with hyperbaric oxygen

Cited by 45 publications

References 7 publications

Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

Hyperbaric Oxygen and Radiotherapy

Hyperbaric Oxygen for Treating Wounds

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