The treatment of osteoporosis with calcium infusions

Pak, Charles Y.C.; Zisman, Elias; Evens, Ronald G.; Jowsey, Jenifer; Delea, Catherine S.; Bartter, Frederic C.

doi:10.1016/0002-9343(69)90236-8

Cited by 58 publications

(12 citation statements)

References 19 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suppression of vow by hypercalcemia stimulation of calcitonin activity has not been ruled out but is less likely in view of its short action. This evidence supports the results and clinically significant hypothesis of Pak et al (27) and Jowsey, Hoye, Pak, and Bartter (28) that transient hypercalcemia may produce prolonged reduction of excessive bone breakdown.…”

supporting

confidence: 90%

Direct Measurement of Osteolysis in Man

Hansen¹,

Gordan²,

Prussin³

1973

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Precise, direct measurement of bone calcium release (vo) has been accomplished using a continuous tracer administration (CTA) technique. Dietary calcium (96.97% 4OCa) is replaced by 4OCa (99.991% 40Ca) and blood levels of the naturally occuring isotope 48Ca are monitored by neutron activation analysis as a function of time. 48Ca abundance falls as this isotope is excreted and only partially replaced by release from bone. After a suitable period, an asymptotic abundance of 48Ca in serum, E, is approached which is the fraction of the turnover rate of the rapidly exchangeable calcium pools coming from the skeleton (E = V/Vt). E is determined with a standard error of 2%, providing a precise, sensitive index of v,. 13 studies in three normal men and one postmenopausal woman receiving maintenance estrogen show large intersubject variations in parameters of calcium metabolism using both CTA and pulse tracer administration (PTA) plus balance techniques. Induced hypercalcemia results in a prolonged decrease in vo. Glucocorticoid therapy initially and consistently induces a marked hypercalciuria while effects on most other parameters of calcium kinetics are variable. In two men E fell when testosterone was added to glucocorticoid treatment, consistent with the known antiosteolytic effect of androgens, despite the short period of study.

show abstract

supporting

confidence: 90%

Direct Measurement of Osteolysis in Man

Hansen¹,

Gordan²,

Prussin³

1973

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…This gradually increased in severity over succeeding months and he became unable to walk. One year after the onset of symptoms idiopathic juvenile osteoporosis was diagnosed, and he received three courses of intravenous infusions of calcium gluconate [6], each consisting of 10 g of elemental calcium. Clinical and radiologic deterioration occurred during this period, the x-ray pattern changing from cortical striation to gross cortical thinning.…”

Section: Case Reportmentioning

confidence: 99%

Bone metabolism in idiopathic juvenile osteoporosis: A case report

1983

View full text Add to dashboard Cite

A previously healthy 12-year-old boy developed pain on walking and x-rays showed osteoporosis. Over the next 2 years deterioration occurred, the condition became extremely severe, and he was confined to a wheelchair. After 5 years, marked kyphoscoliosis and pigeon chest deformity were present and little increase in height occurred. A wheelchair accident at the age of 17 resulted in several major long bone fractures. Iliac crest biopsies were taken at ages 15 and 17, and subjected to quantitative histology. A histochemical technique for osteoclast recognition by acid phosphatase activity showed resorption parameters to be normal. Double tetracycline labeling and histochemical identification of osteoblasts showed no abnormality of endosteal bone formation. Because of "coupling" of endosteal formation and resorption, these measurements might primarily reflect bone turnover. Failure of periosteal bone formation as shown by failure of radial growth of long bones and of epiphyseal growth was clearly evident. It is likely that osteoporosis developed in this patient due to a reduction in bone formation of unknown etiology rather than by increased bone resorption.

show abstract

“…Pak, Zisman, Evens, Jowsey, Delea, and Bartter (1969) treated six patients with idiopathic osteoporosis and fractures using intravenous calcium infusions. They reported improvement both clinical and in calcium retention, bone formation was enhanced, bone resoprtion reduced, and gastrointestinal calcium absorption increased.…”

mentioning

confidence: 99%