The Treatment of Muscle Atrophy After Rotator Cuff Tears Using Electroconductive Nanofibrous Matrices

Tang, Xiaoyan; Shemshaki, Nikoo Saveh; Vernekar, Varadraj N.; Prabhath, Anupama; Kuyinu, Emmanuel; Kan, Ho-Man; Barajaa, Mohammed; Khan, Yusuf; Laurencin, Cato T.

doi:10.1007/s40883-020-00186-8

Cited by 16 publications

(20 citation statements)

References 51 publications

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“…The wrinkles mainly resulted from the amphiphilicity of the GO flakes, which self-assemble and stack over one another to form the multilayer GO film as water is slowly evaporated [ 59 , 60 ]. Recent molecular dynamics simulation studies have shown that wrinkled surfaces on graphene-based materials possess greater interactions between peptides/proteins and graphenic basal planes owing to their greater surface area at the interface [ 61 , 62 , 63 ]. When the designated peptide sequences were noncovalently adsorbed onto the m-GO films, their surface morphology exhibited different trends ( Figure 1 b–e and Figure S1 ) and showed a decrease in surface roughness (mean square roughness, Rq) ( Figure 1 f).…”

Section: Resultsmentioning

confidence: 99%

Peptide Conjugate on Multilayer Graphene Oxide Film for the Osteogenic Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

et al. 2021

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Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated. The results demonstrated that the peptide conjugate on the m-GO film did not hamper the normal growth of WJ-MSCs but supported the growth of WJ-MSCs after the 6-day culture period. In addition, the osteogenic differentiation of WJ-MSCs on the peptide/m-GO films was enhanced as compared with the parent m-GO film. Therefore, such peptide-conjugated m-GO films could provide a highly biocompatible and multifunctional 2D material to tailor the potential application of WJ-MSCs in bone tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Peptide Conjugate on Multilayer Graphene Oxide Film for the Osteogenic Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

et al. 2021

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“…Successive jet initiates from the tip of the Taylor cone, and then it is continuously stretched and thinned down by the electrostatic force overcoming the liquid surface tension [ 81 ]. The electrospinning process requires particular attention to factors influencing the structure and size of electrospun fibers and preventing the break-up of the fibers during the process, such as solution concentration, polymer average molecular weight and distribution, viscosity, electric field, solution feed rate, and voltage [ 84 ]. Several research groups have utilized the electrospinning process for natural polymers-based tissue engineering scaffolds.…”

Section: Electrospinningmentioning

confidence: 99%

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

et al. 2021

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The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large range of biomaterials supporting the use of fabrication technologies. This paper presents a review of scaffold fabrication methods starting from polymer solutions that provide highly porous structures under controlled process parameters. In this review, general information of solution-based technologies, including freeze-drying, thermally or diffusion induced phase separation (TIPS or DIPS), and electrospinning, are presented, along with an overview of their technological strategies and applications. Furthermore, the differences in the fabricated constructs in terms of pore size and distribution, porosity, morphology, and mechanical and biological properties, are clarified and critically reviewed. Then, the combination of these techniques for obtaining scaffolds is described, offering the advantages of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design.

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“…Alternative strategies are therefore required. Biomaterials are powerful tools to support the cellular microenvironment as well as to provide sufficient contractile strength to match native skeletal muscle [ 8 , 123 , 124 , 125 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

“…Various biomaterial-based strategies with different physical and chemical behaviors have been investigated for the treatment of muscle injuries [ 8 ]. Hydrogels are 3D crosslinked hydrophilic polymeric matrices with a high water content that closely mimic the native aqueous environment of the body [ 125 , 126 ]. They have structural similarities to the natural ECM and can be administered with less invasive strategies [ 122 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

“…Hydrogels based on natural elements are ideal candidates as they elicit a limited inflammatory response, have structurally similar elements to the body and they are highly effective in triggering the skeletal muscle regeneration process [ 136 , 137 ]. Recent strategies have focused on naturally derived hydrogel systems to supply essential biochemical signals required for cell adhesion, proliferation, and myogenic differentiation [ 125 ]. Especially, the integration of ECM components into the composition of biomaterials holds great promise for use in muscle regeneration [ 8 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

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Current Strategies for the Regeneration of Skeletal Muscle Tissue

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et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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The Treatment of Muscle Atrophy After Rotator Cuff Tears Using Electroconductive Nanofibrous Matrices

Cited by 16 publications

References 51 publications

Peptide Conjugate on Multilayer Graphene Oxide Film for the Osteogenic Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Peptide Conjugate on Multilayer Graphene Oxide Film for the Osteogenic Differentiation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

Current Strategies for the Regeneration of Skeletal Muscle Tissue

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